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Researchers identify anti-inflammatory prodrug Minnelide with potential against SARS-CoV-2

Using a transgenic mouse model of COVID-19, they have observed that treatment with Minnelide reduces viral load and inflammation in the lungs and improves survival. The study is currently available on the bioRxiv* preprint server.

9 May 2021

Compound from tropical ginger plant can help in the treatment of inflammatory diseases

Many natural compounds have various anti-inflammatory and other beneficial properties that humans have been utilizing for medicinal purposes for hundreds of years.

7 May 2021

Researchers report encouraging results from experimental antiviral targeting Marburg virus

The Marburg virus, a relative of the Ebola virus, causes a serious, often-fatal hemorrhagic fever. Transmitted by the African fruit bat and by direct human-to-human contact, Marburg virus disease currently has no approved vaccine or antivirals to prevent or treat it.

7 May 2021

Study reports vitamin C inhibits SARS-CoV-2 virus main protease

Based on structural analysis, researchers found that vitamin C binds to 3CLpro, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease essential in viral replication. In vitro cell inhibition studies also showed vitamin C could inhibit 3CLpro, indicating a possible new antiviral treatment method.

6 May 2021

Study examines artemisinin-based combination therapy as first-line treatment for malaria

When a mosquito begins to nibble on you, it is not merely feeding on your blood, it is also injecting its saliva into your skin. If that saliva happens to be full of parasites carrying malaria or other diseases from its last victim, then most likely you will become infected, too.

6 May 2021

Study details the complex chemistry and ever-expanding uses of hyaluronic acid

Hyaluronic acid (HA) is more than a buzzword ingredient touted by skincare brands. The "workhorse" capabilities of this biopolymer, which is present in most mammalian tissues, have fascinated scientists for decades.

6 May 2021

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

A team of scientists from the USA and Canada has recently identified and characterized a novel small-molecule compound inhibitor of cellular serine protease TMPRSS2, which shows significant antiviral potency against emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 May 2021

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Researchers from the University of Liverpool have shown the potential of repurposing an existing and cheap drug into a long-acting injectable therapy that could be used to treat Covid-19.

5 May 2021

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

Researchers have identified a gene expressed in children with acute myeloid leukemia (AML) that could serve as a new immunotherapy treatment target, according to a new study published today in Blood Advances, a journal of the American Society of Hematology.

5 May 2021

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

Researchers at University of California San Diego School of Medicine, with colleagues elsewhere, have used gene therapy to prevent learning and memory loss in a mouse model of Alzheimer's disease (AD), a key step toward eventually testing the approach in humans with the neurodegenerative disease.

5 May 2021

Individuals with intellectual disabilities faced triage biases during COVID-19 pandemic

When COVID-19 patients began filling up ICUs throughout the country in 2020, health care providers faced difficult decisions. Health care workers had to decide which patients were most likely to recover with care and which were not so resources could be prioritized.

4 May 2021

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

A vexing problem in the development of vaccines has been the need to achieve the right glycosylation profile for the viral antigens. A new study, recently released as a preprint on the bioRxiv* server, shows how a sequential cell-free approach produced complex N-glycans from simpler types, in a one-pot reaction.

4 May 2021

Four-part small-molecule cocktail can prevent cellular stress

Researchers at the National Institutes of Health (NIH) have devised a four-part small-molecule cocktail that can protect stem cells called induced pluripotent stem cells (iPSCs) from stress and maintain normal stem cell structure and function.

4 May 2021

Hopeaphenol inhibits entry of SARS-CoV-2 variants of concern into cells

A new study, released as a preprint on the bioRxiv* server, reports promising results with the natural product hopeaphenol, which successfully prevented the entry of the virus into host cells.

3 May 2021

Novel compound in avocados may offer a route to better leukemia treatment

A compound in avocados may ultimately offer a route to better leukemia treatment, says a new University of Guelph study.

29 Apr 2021

Obesity and high-salt diet pose bigger, seemingly synergistic cardiovascular risks for females

Obesity and a high-salt diet are both bad for our hearts but they are bigger, seemingly synergistic risks for females, scientists report.

29 Apr 2021

Prenatal POP exposure may increase the risk of metabolic disorders in adolescence

Exposure before birth to persistent organic pollutants (POPs)-- organochlorine pesticides, industrial chemicals, etc.--may increase the risk in adolescence of metabolic disorders, such as obesity and high blood pressure.

29 Apr 2021

New genetically encoded sensor helps detect drugs of abuse

A genetically encoded sensor to detect hallucinogenic compounds has been developed by researchers at the University of California, Davis. Named psychLight, the sensor could be used in discovering new treatments for mental illness, in neuroscience research and to detect drugs of abuse. The work is published April 28 in the journal Cell.

29 Apr 2021

Repairing faulty drains could be key to unlocking the potential of Alzheimer's therapies

Experimental Alzheimer's drugs have shown little success in slowing declines in memory and thinking, leaving scientists searching for explanations.

29 Apr 2021

New compound could alleviate neurological symptoms of CHARGE syndrome

CHARGE syndrome is a rare genetic disorder affecting about 1 in 10,000 newborns. It can lead to neurological and behavioural disorders for which no treatment is currently available.

28 Apr 2021

Compound News and Research

Researchers identify anti-inflammatory prodrug Minnelide with potential against SARS-CoV-2

Compound from tropical ginger plant can help in the treatment of inflammatory diseases

Researchers report encouraging results from experimental antiviral targeting Marburg virus

Study reports vitamin C inhibits SARS-CoV-2 virus main protease

Study examines artemisinin-based combination therapy as first-line treatment for malaria

Study details the complex chemistry and ever-expanding uses of hyaluronic acid

Researchers identify potent small molecule TMPRSS2 inhibitor against SARS-CoV-2

Repurposing an existing, cheap drug into long-acting injectable therapy to treat Covid-19

Researchers identify new immunotherapy treatment target for acute myeloid leukemia in children

Researchers use gene therapy to prevent learning, memory loss in Alzheimer's mouse model

Individuals with intellectual disabilities faced triage biases during COVID-19 pandemic

Could in vitro glycoengineering help produce better SARS-CoV-2 spike candidates for vaccine research?

Four-part small-molecule cocktail can prevent cellular stress

Hopeaphenol inhibits entry of SARS-CoV-2 variants of concern into cells

Novel compound in avocados may offer a route to better leukemia treatment

Obesity and high-salt diet pose bigger, seemingly synergistic cardiovascular risks for females

Prenatal POP exposure may increase the risk of metabolic disorders in adolescence

New genetically encoded sensor helps detect drugs of abuse

Repairing faulty drains could be key to unlocking the potential of Alzheimer's therapies

New compound could alleviate neurological symptoms of CHARGE syndrome

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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