Biologics Drug / Agent News and Research

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Combining medications often best strategy to battle rheumatoid arthritis

For patients with rheumatoid arthritis, combining one well-known, lower-cost synthetic drug with one of six biologic medications often works best to reduce joint swelling or tenderness, according to a new report by researchers at the RTI International-University of North Carolina at Chapel Hill Evidence-based Practice Center, which is sponsored by the Agency for Healthcare Research and Quality.

19 Nov 2007

Gene chips provide new technique to evaluate organ rejection in kidney transplants

A new article appearing in American Journal of Transplantation describes a revolutionary technique for more clearly identifying the possibility of organ rejection in kidney transplants.

19 Nov 2007

YKL-40 protein may play a role in severe asthma

A protein measured in a simple blood test may be a new biomarker to identify patients with the most serious form of asthma, Yale School of Medicine researchers report in the New England Journal of Medicine.

15 Nov 2007

Bevacizumab improves ovarian cancer treatment

A new study appearing in International Journal of Gynecological Cancer states that Bevacizumab, a biologic anti-cancer agent that prevents tumor growth by interfering with the formation of new blood vessels, may have the potential to improve the efficacy of standard combination chemotherapy in ovarian cancer.

1 Nov 2007

Research identifies two genes that may play a role in insulin resistance

New research from UAB (University of Alabama at Birmingham) identifies two genes that may play a role in insulin resistance, opening a new avenue for researchers searching for treatments for type 2 diabetes and metabolic syndrome.

28 Oct 2007

Attenuation of NASH by stimulation of free fatty acid metabolism

Medically-complicated obesity is a societal problem that needs to be solved. Liver disease, specifically non-alcoholic steatohepatitis or NASH, is just one of the many complications of increased body weight.

28 Oct 2007

Novel and accurate method for preoperative diagnosis of pancreatic solid pseudopapillary tumor

Given the difficulty regarding pancreatic biopsy procedures, a research group led by Dr. Chatzipantelis investigates the relatively novel preoperative and bloodless technique of image-guided fine-needle aspiration (FNA), and explores its value in diagnosing pancreatic lesions.

24 Oct 2007

FDA approves change in storage conditions for Humate-P

The U.S. Food and Drug Administration has approved a change in the storage conditions for Humate-P, a treatment for bleeding in certain patients with hemophilia A or von Willebrand Disease (vWD).

22 Oct 2007

FDA expands approved age range for Menactra, bacterial meningitis vaccine

The U.S. Food and Drug Administration has expanded the approved age range for Menactra, a bacterial meningitis vaccine, to include children ages 2 to 10 years.

19 Oct 2007

Abbott creates one molecule with two antibody functions

Abbott has reported that its scientists are the first to discover a proprietary technology that combines the function and specificity of two or more monoclonal antibodies (mAbs) into one molecular entity that demonstrates drug-like properties and manufacturing feasibility.

19 Oct 2007

Usage of complementary and alternative medicine therapies high among those with obstructive sleep apnea hypopnea syndrome

A high proportion of patients with obstructive sleep apnea hypopnea syndrome (OSAHS) report previous or current use, and interest in future use, of complementary and alternative medicine (CAM) therapies, according to a study published in the October 15 issue of the Journal of Clinical Sleep Medicine (JCSM).

16 Oct 2007

African-American men have a slightly higher risk of PSA recurrence

African-American men are more likely to have their prostate cancer return after treatment, but their disease is no more aggressive when it does recur than that of their white counterparts, according to a study led by Duke Prostate Center researchers.

10 Oct 2007

$4 million nursing grant for premature infants

The University of Illinois at Chicago College of Nursing has received a $4.1 million federal grant to develop ways to improve the early growth and development of premature infants who have two or more social-environmental risks such as poverty or minority status.

4 Oct 2007

Promising trial results show biologic therapy ustekinumab significantly improved psoriasis

The first reported findings from an international, Phase 3 study showed that more than two-thirds of patients with moderate to severe plaque psoriasis receiving two doses of ustekinumab (CNTO 1275) achieved at least a 75 percent reduction in psoriasis at week 12, the primary endpoint of the study, as measured by the Psoriasis Area and Severity Index (PASI 75).

4 Oct 2007

Judge acquits Canadian doctors, U.S. drug company in tainted blood case

A Canadian judge on Monday acquitted New Jersey-based Armour Pharmaceutical Company and four Canadian doctors -- including the former medical director of the Canadian Red Cross and two government officials -- of charges related to blood products contaminated with HIV and hepatitis C, the New York Times reports (Austen, New York Times, 10/2).

2 Oct 2007

Accurate prostate cancer diagnosis depends on biopsy location

The part of the prostate that is biopsied may matter more than the number of biopsy samples taken for accurately diagnosing prostate cancer, according to a study by researchers at SUNY Upstate Medical University.

1 Oct 2007

FDA approves Afluria in time for flu season

The U.S. Food and Drug Administration today approved Afluria, an additional seasonal influenza vaccine for the immunization of people ages 18 and older.

29 Sep 2007

Adnexus Therapeutics to become a subsidiary of Bristol-Myers Squibb

Bristol-Myers Squibb and Adnexus Therapeutics have announced the companies have signed a definitive agreement under which Bristol-Myers Squibb will acquire privately held Adnexus Therapeutics, developer of a new therapeutic class of biologics called Adnectins.

25 Sep 2007

Process of necrosis redefined in landmark study

A new study led by investigators from the University of Pittsburgh School of Medicine demonstrates that the process of necrosis, long thought to be a chaotic, irreversible pathway to cell death, may actually be triggered as part of a regulated response to stress by a powerful protein, SRP-6, that can potentially halt necrosis in its path.

21 Sep 2007

FDA expands use of influenza vaccine FluMist

The U.S. Food and Drug Administration has approved expanding the population for use of the nasal influenza vaccine FluMist to include children between the ages of 2 and 5.

20 Sep 2007