DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

New study targets the methylation profile of microglia from human brain

In the central nervous system, microglial cells play critical roles in development, aging, brain homeostasis, and pathology. Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states.

29 Dec 2021

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

Scientists at the La Jolla Institute for Immunology have uncovered how loss of TET enzymes can lead to B cell lymphoma. Their research, published in Nature Immunology, could potentially open opportunities for designing drug treatment strategies to target malignant cells in many cancers.

24 Dec 2021

Scientists develop novel method to monitor remote immune processes within cells

Our immune systems work hard to keep us healthy and to protect us against bacteria, viruses, fungi, parasites and cancerous cells.

15 Dec 2021

Epigenetic clocks have potential as biomarkers of COVID-19 vaccine responses

New findings have important implications for research into the impact of COVID-19 and the mRNA vaccination on epigenetic aging in the immune system.

7 Dec 2021

New epigenetic editing technique may advance the treatment of many diseases

Type 1 diabetes, rheumatoid arthritis, and cancer are just some of the disorders associated with specific genes not "turning on" and "turning off" as they should.

9 Nov 2021

Researchers receive $9.1 million grant to study resilience in older adults before and during the pandemic

The National Institute on Aging of the National Institutes of Health has awarded researchers at Washington University School of Medicine in St. Louis a five-year, $9.1 million grant to study resilience in older adults before and during the COVID-19 pandemic, as well as the pandemic's cognitive and emotional effects on older adults.

30 Oct 2021

Study provides a specific target to tackle breast cancer relapse

Molecular targets for therapies that could prevent breast cancer recurrence have been identified by a group of German, Norwegian and British scientists who analyzed tumour cells that proved resistant to the original treatment.

25 Oct 2021

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Oncotarget published "Diverse transcriptional regulation and functional effects revealed by CRISPR/Cas9-directed epigenetic editing" which reported that the adequate functioning of this process is indispensable for tissue homeostasis and cell fate determination.

11 Oct 2021

Scientists make inroads into creating an atlas of the mouse brain

It takes billions of cells to make a human brain, and scientists have long struggled to map this complex network of neurons.

6 Oct 2021

Neuroscientists unveil detailed atlas of brain cells

When you clicked to read this story, a band of cells across the top of your brain sent signals down your spine and out to your hand to tell the muscles in your index finger to press down with just the right amount of pressure to activate your mouse or track pad.

6 Oct 2021

Depression during pregnancy linked with chemical modifications to placental genes

Episodes of maternal stress or depression during pregnancy are associated with chemical modifications to placental genes, according to a study by researchers from the National Institutes of Health.

6 Oct 2021

Advanced technique offers new insights about the dynamics of gliomas

A team led by researchers at Weill Cornell Medicine, the New York Genome Center, Harvard Medical School, Massachusetts General Hospital and the Broad Institute of MIT and Harvard has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors.

2 Oct 2021

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex. TDP-43 is a protein that tends to accumulate in increasing amounts, and the amount is strictly controlled by the splicing of TDP-43. Through cell experiments and analysis of human brain tissue, researchers at Brain Research Institute, Niigata University, led by Akihiro Sugai, M.D., Ph.D., have found that methylation of TDP-43 DNA is involved in the background of motor cortex involvement with aging in ALS

29 Sep 2021

Differences in DNA methylation could accurately predict progression of liver disease

Findings of a national study led by the Translational Genomics Research Institute, an affiliate of City of Hope, identify potential biomarkers that might eventually be used to diagnose progressive stages of liver disease.

20 Sep 2021

Researchers explore whether cocoa supplementation can reduce aging

Whether consuming cocoa, known to be packed with powerful antioxidants that protect our cells from damage, helps us age better, is a question scientists want to definitively answer.

14 Sep 2021

Researchers receive $12.8M renewal grant to reveal how smoking causes distinct lung diseases

Despite cigarette smoking being the single most preventable risk factor for both chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF), two devastating diseases that make it hard to breathe, about 44 million American adults continue to smoke.

8 Sep 2021

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

For species that rely on sexual reproduction, including mice and men, offspring can only happen if sperm from the male fertilize eggs from the female.

7 Sep 2021

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Genomics, proteomics, metabolomics, transcriptomics -- rapid advances in high-throughput biomedical technologies has enabled the collection of data with unprecedented detail from the growing number of omics.

27 Aug 2021

An existing drug may function as targeted therapy for ALL in children

A new study from Linköping University has shown that the tumour-inhibiting gene TET2 is silenced in a large fraction of cases of acute lymphoblastic leukemia (ALL) in children.

25 Aug 2021

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

Investigators who previously developed a recipe for turning skin cells into primitive muscle-like cells that can be maintained indefinitely in the lab without losing the potential to become mature muscle have now uncovered how this recipe works and what molecular changes it triggers within cells.

19 Aug 2021

DNA Methylation News and Research

Further Reading

New study targets the methylation profile of microglia from human brain

LJI researchers discover how loss of TET enzymes can lead to B cell lymphoma

Scientists develop novel method to monitor remote immune processes within cells

Epigenetic clocks have potential as biomarkers of COVID-19 vaccine responses

New epigenetic editing technique may advance the treatment of many diseases

Researchers receive $9.1 million grant to study resilience in older adults before and during the pandemic

Study provides a specific target to tackle breast cancer relapse

CRISPR/Cas9-directed epigenetic editing reveals diverse transcriptomic regulation and functional effects

Scientists make inroads into creating an atlas of the mouse brain

Neuroscientists unveil detailed atlas of brain cells

Depression during pregnancy linked with chemical modifications to placental genes

Advanced technique offers new insights about the dynamics of gliomas

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Differences in DNA methylation could accurately predict progression of liver disease

Researchers explore whether cocoa supplementation can reduce aging

Researchers receive $12.8M renewal grant to reveal how smoking causes distinct lung diseases

Optimized strategy for generating male germ-cells from mouse pluripotent stem cells

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

An existing drug may function as targeted therapy for ALL in children

Research could enable clinicians to produce patient-matched cells for treating muscle-related diseases

DNA Methylation eBook

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Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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