Low Density Lipoprotein (LDL) News and Research

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The association of lipid levels with the risk of COVID-19 infection, hospitalization, disease severity, and mortality

A recent study conducted by a team of international scientists has highlighted that individuals with high serum levels of high-density lipoprotein-cholesterol are less susceptible to SARS-CoV-2 infection.

6 Apr 2022

Addition of alirocumab to high-intensity statin treatment reduces key measures of plaque vulnerability

Compared with a placebo, the addition of the injectable cholesterol-lowering drug alirocumab to high-intensity statin treatment in patients who have had a heart attack resulted in twofold greater reductions in three key measures of plaque vulnerability that signal risk for future cardiac events, according to research presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

While there are effective therapies to reduce the risk of heart disease by lowering low-density lipoprotein (LDL), or "bad" cholesterol, and other lipids, to date there are no approved treatments to lower lipoprotein(a), a lesser-known driver of heart disease risk.

3 Apr 2022

Investigational drug vupanorsen reduces non-HDL cholesterol by up to 28%

The investigational drug vupanorsen reduced total levels of non-high-density lipoprotein (non-HDL) cholesterol by up to 28% in patients with high cholesterol who were already taking a cholesterol-lowering statin medication, in a study presented at the American College of Cardiology's 71st Annual Scientific Session.

3 Apr 2022

Study describes sequelae presenting more than six months after COVID-19 in non-hospitalized young adults

A recent study described COVID-19 sequelae developed in non-hospitalized young adults more than six months after COVID-19 infection.

15 Feb 2022

Significance of metabolic parameters in COVID-19 prognosis

In a new study, researchers evaluated the significance of metabolic parameters in determining COVID-19 prognosis.

27 Jan 2022

Fewer than 1 in 5 U.S. adults with Type 2 diabetes meet targets to reduce heart disease risk

Fewer than 1 in 5 adults with Type 2 diabetes in the U.S. are meeting targets to reduce heart disease risk. Fortunately, available therapies can help when combined with new approaches that address social determinants of health and other barriers to care, according to a new American Heart Association scientific statement published today in the Association's flagship journal Circulation.

10 Jan 2022

Cholesterol-lowering drugs not helpful in reducing COVID-related mortality or severity

In the worldwide effort to battle SARS-CoV-2, the virus that causes COVID-19, researchers have often turned to medications used as therapies for other conditions in the hopes of finding ones that either kill the coronavirus or lessen the impacts from its infection.

26 Oct 2021

Women with type 2 diabetes and CVD less likely to reach treatment targets than men, study finds

Women with type 2 diabetes and cardiovascular disease (CVD), or at high risk of developing CVD, are less likely to reach recommended treatment targets than men, according to an international study involving almost 10,000 patients with type 2 diabetes, being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD), held online this year (27 Sept-1 Oct). Nevertheless, women were less likely to experience adverse CVD outcomes apart from a stroke.

27 Sep 2021

Remnant cholesterol provides an accurate stand-alone metric for predicting heart attack, stroke risk

An analysis of data gathered from more than 17,000 adults by Johns Hopkins Medicine researchers supports the belief that so-called "remnant cholesterol" (RC) provides an accurate stand-alone metric — just as doctors currently use measures of low-density lipoprotein (LDL) — for predicting risk of clogged arteries, heart attacks and strokes.

8 Sep 2021

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

Eating about ½ cup of walnuts every day for two years modestly lowered levels of low-density lipoprotein (LDL) cholesterol, known as "bad cholesterol," and reduced the number of total LDL particles and small LDL particles in healthy, older adults, according to new research published today in the American Heart Association's flagship journal Circulation.

30 Aug 2021

Study finds potential link between eating saturated fat from meat and heart disease risk

A study in more than 100,000 individuals has found a potential link between eating saturated fat from meat and developing heart disease.

26 Aug 2021

Pecan-enriched diets can improve a person's cholesterol levels, study shows

While the proper pronunciation of pecan remains a subject of debate, University of Georgia researchers have shown the tree nut can dramatically improve a person's cholesterol levels.

23 Aug 2021

Drinking alcohol at a young age associated with accelerated arterial stiffening

Drinking alcohol during adolescence to young adulthood is associated with accelerated arterial stiffening, a precursor to cardiovascular disease. That's the finding of a study presented at ESC Congress 2021.

23 Aug 2021

Sphingolipid profile could predict severity of heart disease in African American patients with lupus

A team of researchers at the Medical University of South Carolina report in Frontiers in Immunology that they have identified a type of fat known as a sphingolipid that could predict the severity of heart disease in African American patients with lupus.

16 Aug 2021

Researchers identify immune protein linked to rare neurodegenerative disease

UT Southwestern researchers have identified an immune protein tied to the rare neurodegenerative condition known as Niemann-Pick disease type C.

21 Jul 2021

Mice study identifies pathways that link high-fat diet to atherosclerosis

It's long been known that a high-fat diet can lead to clogged arteries, but we have only recently begun to learn in detail how the process works. A new study in experimental mice could go a long way to finding treatments to keep arteries open and flowing.

9 Jul 2021

The potential therapeutic value of CDK6 inhibitors in critical COVID-19

While drug repurposing has been explored in the context of the current coronavirus disease 2019 (COVID-19) pandemic, the success of this strategy has been limited so far. A new study, released as a preprint on the medRxiv* server, describes a new method of identifying a promising hit among drugs already in use.

24 May 2021

Researchers use base editing to sustainably lower high LDL cholesterol levels

Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence.

19 May 2021

Cardiovascular risk factors accumulated from childhood linked to poorer brain function at midlife

Managing weight, blood pressure and cholesterol in children may help protect brain function in later life, according to new research published today in the American Heart Association's flagship journal Circulation.

10 May 2021

Low Density Lipoprotein (LDL) News and Research

The association of lipid levels with the risk of COVID-19 infection, hospitalization, disease severity, and mortality

Addition of alirocumab to high-intensity statin treatment reduces key measures of plaque vulnerability

Experimental siRNA therapeutic shows promise to reduce an important driver of heart disease risk

Investigational drug vupanorsen reduces non-HDL cholesterol by up to 28%

Study describes sequelae presenting more than six months after COVID-19 in non-hospitalized young adults

Significance of metabolic parameters in COVID-19 prognosis

Fewer than 1 in 5 U.S. adults with Type 2 diabetes meet targets to reduce heart disease risk

Cholesterol-lowering drugs not helpful in reducing COVID-related mortality or severity

Women with type 2 diabetes and CVD less likely to reach treatment targets than men, study finds

Remnant cholesterol provides an accurate stand-alone metric for predicting heart attack, stroke risk

Daily walnut consumption lowers LDL cholesterol levels and may promote cardiovascular health

Study finds potential link between eating saturated fat from meat and heart disease risk

Pecan-enriched diets can improve a person's cholesterol levels, study shows

Drinking alcohol at a young age associated with accelerated arterial stiffening

Sphingolipid profile could predict severity of heart disease in African American patients with lupus

Researchers identify immune protein linked to rare neurodegenerative disease

Mice study identifies pathways that link high-fat diet to atherosclerosis

The potential therapeutic value of CDK6 inhibitors in critical COVID-19

Researchers use base editing to sustainably lower high LDL cholesterol levels

Cardiovascular risk factors accumulated from childhood linked to poorer brain function at midlife

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