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Immunotherapy combination sets a new standard of care for extensive-stage small cell lung cancer

In patients with extensive-stage small cell lung cancer (ES-SCLC), tarlatamab, a bispecific T-cell engager, plus durvalumab as first-line maintenance therapy extended median overall survival by more than eight months, more than tripled progression-free survival, and reduced the risk of death by 58% compared to durvalumab alone, according to results of the phase 3 open-label, multicenter, randomized DeLLphi-305 study, which was presented by Jacob Sands, MD, Associate Chief of the Lowe Center for Thoracic Oncology at Dana-Farber Cancer Institute, during the Presidential Symposium at the European Society for Medical Oncology (ESMO) Congress 2026 in Madrid, Spain, on Oct. 24.

26 Oct 2026

AI drug recommendations show bias toward costly branded products

Large language models (LLMs), such as ChatGPT and Claude, are increasingly being used to provide health information to the public.

26 Oct 2026

New drug effectively decreases recurrence of and death from endometrial cancer

A new drug is effective at decreasing recurrence of and death from endometrial cancer, a landmark international study shows.

26 Oct 2026

UCL scientists design symbolic AI digital twins to treat cancer

In a new paper published in Cell Reports Medicine, the UCL team outline how they, in collaboration with a University of Cambridge team, developed a new type of treatment-predicting computer program that uses an individual's detailed genetic fingerprint to explore which treatments, if any, may kill their cancer – especially when standard treatments have failed.

26 Oct 2026

Proteins linked to Alzheimer's found to assist sperm cells

Unexpectedly, a kind of protein that is usually linked with diseases in the brain may play a vital role in semen, helping shepherd genetic material into sperm cells, scientists at Columbia's Zuckerman Institute report today in the research journal Molecular Cell.

26 Oct 2026

African health experts urge immediate action over new Ebola cases

African health experts have called for an immediate and coordinated response from pan-African authorities after new cases of the Bundibugyo Ebola virus emerged in Kenya and Nigeria.

26 Oct 2026

Medical societies release landmark framework redefining women's heart health

Today, the American Heart Association, American Academy of Pediatrics, American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine released a landmark publication that redefines heart health in girls and women.

26 Oct 2026

Physical activity may help lower genetic risk of depression in adults

Adding physical activity to a daily routine may seem like a simple step for better health, but research from Kansas State University suggests it could be especially beneficial for individuals with a genetic predisposition to depression, potentially helping reduce their risk and ease their symptom burden.

26 Oct 2026

Simple drug adjustment reduces kidney damage during septic shock surgery

A simple adjustment to drugs given during operations for septic shock could prevent thousands of patients suffering kidney damage, according to a major trial.

26 Oct 2026

New report urges unified lifecycle approach to women's heart health

A new approach to women's heart health may offer them a lifetime of opportunities. A trio of scientific papers, published today in the journal Circulation, spells out how fluctuating hormones, mental health and well-being, the heart and the brain are linked and how those connections need to be a routine part of care from a young age.

26 Oct 2026

Researchers discover how faulty matrix structure leads to cell death in newly formed bone

Bone cells called osteocytes help maintain skeletal strength, but how newly formed osteocytes survive remains unclear.

26 Oct 2026

Young mothers see rapid increase in substance-related emergency department visits

Emergency department (ED) visits for use of substances, especially opioids, amphetamines, and cannabis, by mothers with dependent children increased almost 5% a year, in contrast to an increase of almost 2% a year among females without children, according to a large study in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.260078.

26 Oct 2026

Understanding the symptoms and treatments of pelvic organ prolapse

The pelvic floor is a layer of muscles and connective tissues that supports the uterus, bladder, urethra, vagina and rectum. The pelvic floor supports the organs in your pelvis from underneath, almost like a hammock.

26 Oct 2026

Study reveals a broad shift away from overtreatment of low-risk prostate cancer

An analysis of United States data reveals a broad shift away from overtreatment of low-risk prostate cancer.

26 Oct 2026

Scientists discover a deep brain structure crucial for holding thoughts

Reading a sentence, following a conversation, solving a problem or deciding what to do next: all of these rely on working memory.

26 Oct 2026

Taking a GLP-1 drug? Here's what the safety evidence really shows

A review on GLP-1 receptor agonists highlights risks like pancreatitis and thyroid cancer, emphasizing individual patient risk over general safety concerns.

26 Oct 2026

Next generation KRAS inhibitor divarasib significantly extends lung cancer survival

Patients with previously treated advanced KRAS G12C-mutant non-small cell lung cancer (NSCLC) lived significantly longer and saw improved disease control when treated with the next-generation KRAS targeted therapy divarasib, according to researchers from The University of Texas MD Anderson Cancer Center.

26 Oct 2026

Drug combination delivers promising survival gains in advanced endometrial cancer

An immunotherapy-based regimen combining durvalumab and the PARP inhibitor, olaparib, demonstrated encouraging long-term survival outcomes for patients with advanced or recurrent endometrial cancer, according to new trial results presented by researchers from The University of Texas MD Anderson Cancer Center.

24 Oct 2026

Massive study identifies genetic variants associated with five major personality traits

A massive genetic study offers one of the clearest pictures yet of how DNA contributes to personality, identifying genetic variants associated with five major personality traits.

24 Oct 2026

Newly discovered protein controls the space between mitochondrial membranes

Mitochondria are the tiny powerpacks that supply most of the energy our cells need. Their ability to generate this energy relies on a distinctive architecture: two membranes, one tucked inside the other, separated by a narrow gap called the intermembrane space (IMS).

23 Oct 2026