Melanoma Cells News and Research

RSS

New therapeutic strategy exploits acquired vulnerability in drug-resistant cancer

Cancer cells that develop resistance to drugs, pay a price for this, by simultaneously developing a new vulnerability. If this acquired vulnerability can be identified, it may be exploited clinically.

10 May 2018

Direct contact with lymphatic endothelial cells promotes melanoma metastasis

Despite the declining death rates for many individual cancer types, mortality for a few cancers has stabilized or even increased. One of these is melanoma due to its ability, in later stages, to spread to other parts of the body.

2 May 2018

Researchers target telomerase for killing NRAS-mutant melanoma cells

Targeting telomerase was effective at killing NRAS-mutant melanoma cells, and the impact was further enhanced when the strategy was paired with an inhibitor of mitochondrial function, according to study results by The Wistar Institute published in Oncogene.

26 Apr 2018

MD Anderson research provides insight into memory T cell development and disease relapse

Just like people, some T cells have excellent memories. These subtypes known as memory T cells may explain why some immunotherapies are more effective than others and potentially lead to researchers designing more effective studies using combination checkpoint blockade treatments, according to experts at The University of Texas MD Anderson Cancer Center.

16 Apr 2018

UCLA scientists identify four subtypes of melanoma with different drug sensitivities

Melanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states - that is, to regress to an earlier stage of development - which can lead it to become resistant to treatment.

12 Apr 2018

Researchers create new compound that appears to activate cancer-fighting T cells

Invariant natural killer T (iNKT) cells are powerful weapons our body's immune systems count on to fight infection and combat diseases like cancer, multiple sclerosis, and lupus. Finding ways to spark these potent cells into action could lead to more effective cancer treatments and vaccines.

2 Apr 2018

Targeting aberrantly active telomerase to treat therapy-resistant melanoma

A study conducted at The Wistar Institute in collaboration with The University of Texas Southwestern Medical Center has demonstrated the efficacy of targeting aberrantly active telomerase to treat therapy-resistant melanoma.

21 Mar 2018

Continuous tracking of melanoma cell invasion helps scientists explain key regulators of metastasis

A team of Italian scientists reported this week that blocking the interaction between urokinase receptor (uPAR) and formyl peptide receptor type 1 (FPR1) suppresses the ability of melanoma cells to migrate, invade through an extracellular matrix, and to burrow through a layer of endothelial cells.

13 Mar 2018

Researchers report potential new role for skin bacteria in protecting against cancer

Science continues to peel away layers of the skin microbiome to reveal its protective properties. In a study published in Science Advances on February 28, University of California San Diego School of Medicine researchers report a potential new role for some bacteria on the skin: protecting against cancer.

1 Mar 2018

Specific bacteria in the intestines can improve response rate to cancer immunotherapy

In the Jan. 5, 2018 issue of Science, researchers from the University of Chicago Medicine show that specific strains of commensal bacteria – the swarms of microorganisms naturally dwelling in the intestines – can improve the response rate to immunotherapy for patients being treated for advanced melanoma.

5 Jan 2018

Researchers discover genetic mechanism for resistance to immunotherapy drugs

An urgent question for cancer scientists is why immunotherapy achieves dramatic results in some cases but doesn't help most patients.

5 Jan 2018

Soil-dwelling bacterium produces potential weapon against melanoma

A type of soil-dwelling bacterium produces molecules that induce death in melanoma cells, research at Oregon State University shows.

4 Jan 2018

Researchers develop new compound that inhibits growth of melanoma cells

An international team of researchers has developed a novel compound that successfully inhibits growth of melanoma cells by targeting specific epigenetic modifying proteins in these cells.

4 Jan 2018

Treatment for skin cancer could be more effective if combined with arthritis drug

Treatment for the most deadly form of skin cancer could be more effective if combined with a well-known drug for rheumatoid arthritis, new research has shown.

19 Dec 2017

Brazilian researchers identify genes linked to melanoma progression

When researchers at the University of São Paulo in Brazil treated human melanoma cell lines with a synthetic compound similar to curcumin, one of the pigments that give turmeric its orange color, they identified genes with altered expression in potentially invasive tumors and malignant cells resistant to chemotherapy.

6 Dec 2017

Study reveals gene linked to metastatic melanoma

A study by Craig J. Ceol, PhD, assistant professor of molecular medicine at the University of Massachusetts Medical School, has revealed a protein active during early embryo development called GDF6 plays a primary role in metastatic melanoma.

4 Dec 2017

Study identifies slowly proliferating and highly invasive melanoma cells

A study conducted at The Wistar Institute has led to the identification of a slowly proliferating and highly invasive melanoma cell subpopulation, characterized by production of a protein associated with invasive behavior. The research was published in the journal Oncogene.

21 Sep 2017

Researchers identify role of tumor-infiltrating B-cells in melanoma progression, resistance to therapy

In a multi-institutional collaborative study, scientists at The Wistar Institute and the Medical University of Vienna, Austria, have identified the role of tumor-infiltrating or tumor-associated B-cells ("TABs") in melanoma progression and resistance to targeted therapy.

20 Sep 2017

Australian researchers make ultimate move in the battle against melanoma

A team of Australian researchers has made the ultimate move in the battle to beat melanoma, successfully trialing a combination of new treatments to stop the disease in its tracks and prevent it from spreading or metastasizing to distant organs.

12 Sep 2017

Study describes link between key melanoma signaling pathway and novel class of drugs

Results of a study by The Wistar Institute have described a correlation between a key melanoma signaling pathway and a novel class of drugs being tested in the clinic as adjuvant therapy for advanced melanoma, providing useful information for a more effective use of this type of treatment.

7 Sep 2017