Pathophysiology News and Research

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Exploring the protective effects of HSD17B13 in hepatic steatosis

Chronic liver disease (CLD) is a growing global health challenge, accounting for millions of deaths each year. Its major contributors include metabolic dysfunction-associated steatohepatitis (MASH), alcoholic liver disease (ALD), and hepatitis C virus infection.

8 Nov 2024

SARS-CoV-2 hijacks host proteins to escape immune clearance

Researchers at the Medical University of Vienna and the Medical University of Innsbruck discovered that SARS-CoV-2 hijacks three important host proteins that dampen the activity of the complement system, a key component of early antiviral immunity.

8 Nov 2024

Preeclampsia and COVID-19 share pathophysiological similarities in pregnant women

During the COVID-19 pandemic, above all before vaccines were available, an alarm was sounded regarding a possible correlation between severe cases of COVID-19 in pregnant women and preeclampsia, a condition characterized by high blood pressure (hypertension) in the expectant mother and high levels of protein in her urine (proteinuria). It can entail dangerous complications for mother and baby.

7 Nov 2024

Research shows how trained immunity links to cardiovascular disease

When thinking about the immune system, most people think about B and T cells and how they can be trained to recognize pathogens, preventing re-infections.

7 Nov 2024

Review: The multifaceted roles of bilirubin in liver health and disease

Bilirubin, the byproduct of hemoprotein breakdown, particularly hemoglobin, is a critical marker in diagnosing, prognosing, and managing liver diseases.

6 Nov 2024

UCD researcher wins European Research Council Synergy Grant for NanoX project

University College Dublin (UCD) researcher Dr Nicola Fletcher has received a coveted European Research Council (ERC) Synergy Grant for her groundbreaking project NanoX.

5 Nov 2024

Could vitamin D be the missing link in managing type 2 diabetes? Recent study weighs in

Vitamin D's role in type 2 diabetes management is evolving, with evidence suggesting it may improve blood sugar levels and reduce diabetes-related inflammation.

29 Oct 2024

Researchers discover key biochemical mechanism in Huntington's disease development

Researchers from the University of Oxford have identified a key biochemical mechanism relevant to the development of Huntington's Disease.

28 Oct 2024

Major donation fuels advances in ophthalmic artificial intelligence

The Icahn School of Medicine has announced a $5 million gift from the John and Daria Barry Foundation for the Center for Ophthalmic Artificial Intelligence (AI) and Human Health.

16 Oct 2024

Breakdancer’s scalp mass removed after years of headspin injuries

Breakdancers can develop a fibrous mass on the scalp, known as the headspin hole, due to repetitive headspins. A recent BMJ Case Report details a case where surgery effectively removed the mass, alleviating symptoms.

14 Oct 2024

NIH funding supports investigation of skeletal stem cells in craniofacial bone disorders

Researchers at UTHealth Houston have been awarded an $8.1 million grant by the National Institutes of Health (NIH) to examine skeletal stem cells as potential drivers of craniofacial bone diseases and deformities.

10 Oct 2024

Researchers identify key mechanism behind atherosclerosis in Hutchinson-Gilford progeria syndrome

A team of researchers from the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), the Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC), and the Instituto de Ciencias de Materiales de Madrid (ICMM-CSIC) has made a significant breakthrough in understanding the underlying causes of cardiovascular disease in patients with Hutchinson-Gilford progeria syndrome (HGPS), an ultra-rare genetic disorder that accelerates the aging process.

7 Oct 2024

Scientists uncover two Crohn’s disease subtypes using lab-grown intestines, offering hope for personalized therapies

Researchers used stem-cell derived organoids from Crohn's disease patients to identify two molecular subtypes, paving the way for personalized treatments targeting specific disease characteristics.

2 Oct 2024

Study reveals widespread long-COVID symptoms, challenging WHO definition

Study reveals that more than one-third of SARS-CoV-2 positive patients experience long-COVID symptoms three months after an emergency department visit, with significant overlap in symptoms observed among negative patients.

1 Oct 2024

How viral persistence and immune dysfunction drive long COVID

Study explores the biological drivers and mechanisms of long COVID, shedding light on its epidemiology and potential therapeutic interventions. It emphasizes the role of viral persistence, immune dysfunction, and coagulation in the development of this condition.

29 Sep 2024

Exploring the role of chemokines in atrial fibrillation development

Announcing a new article publication for Cardiovascular Innovations and Applications journal. Chemokines are a subclass of cytokines, a large family of small secreted proteins that communicate via G protein-coupled heptahelical chemokine receptors on the cell surface.

29 Sep 2024

NIH awards grant to study how dilated cardiomyopathy progresses to heart failure

A University of Arizona College of Medicine – Phoenix researcher was recently awarded a $1.9 million National Institutes of Health grant to study the molecular mechanisms of how dilated cardiomyopathy progresses to heart failure, which could eventually lead to better preventive and treatment options for heart failure.

27 Sep 2024

'Treating Naturally Occurring Disease’, explained by Founder, Professor Noel Fitzpatrick

Humanimal Trust advocates for studying naturally occurring diseases in animals to advance cancer and osteoarthritis treatments for both humans and animals.