Programmed Cell Death News and Research

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Combinatorial biomarker predicts response to immunotherapy in kidney cancer patients

The number of immune cells in and around kidney tumors, the amount of dead cancer tissue, and mutations to a tumor suppressor gene called PBRM1 form a biomarker signature that can predict — before treatment begins — how well patients with kidney cancer will respond to immunotherapy, according to new research directed by investigators at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Institute for Cancer Immunotherapy.

6 Apr 2023

Scientists develop a marker for therapy response in acute myeloid leukemia

With the combination of the drugs Venetoclax and 5-Azacitidine, a new, effective and more tolerable alternative to chemotherapy for the treatment of AML has been available for several years. But for some patients, the drug combination does not work.

17 Mar 2023

Cuproptosis-associated ferroptosis genes linked with immune infiltration in atherosclerosis

Announcing a new article publication for Cardiovascular Innovations and Applications journal. In this study, the authors identify cuproptosis-associated ferroptosis genes in the atherosclerosis microarray of the Gene Expression Omnibus (GEO) database and explored hub gene-mediated immune infiltration in atherosclerosis.

15 Mar 2023

Chemotherapy affects the cellular landscape of tumor microenvironment in pancreatic cancer

Chemotherapy affects the ability of a patient's immune system to attack pancreatic tumors, a new study shows.

1 Mar 2023

PARK2 duplication or microdeletion and neurological diseases

In a recent study published in the Genes journal, researchers assessed the impact of PARK2 duplication or microdeletion on neurological diseases such as Parkinson's.

28 Feb 2023

Critical COVID-19 infection characterized by a shift from naïve T cell phenotypes to an expansion of cytotoxic CD4+ T lymphocyte subsets

Researchers immunophenotyped T lymphocyte responses among unvaccinated individuals, representative of the entire spectrum of the clinical presentation of COVID-19.

28 Feb 2023

Oleic acid: Principal component of olive oil responsible for many health-promoting properties

Oleic acid, the principal component of olive oil, has properties that help to prevent cancer and Alzheimer's disease and to lower cholesterol.

23 Feb 2023

Study identifies a potential new targeted drug for treating acute myeloid leukemia

Targeted drugs have been developed to supplement chemotherapy in the treatment of cancer. These drugs only affect cancer cells, leaving healthy cells alone.

23 Feb 2023

Study links obesity with 21 Alzheimer's disease-related genes

In a new study, researchers from The University of Texas Health Science Center at San Antonio (UT Health San Antonio) link obesity with 21 Alzheimer's disease-related genes, providing a potential mechanistic explanation for why Alzheimer's is sometimes more frequent among adults who experienced obesity in midlife.

22 Feb 2023

Ferroptosis could be the key to making effective immunotherapies against liver cancer

Iron-dependent cell death (ferroptosis) is a type of programmed cell death by means of which the body kills off diseased, defective or superfluous cells.

17 Feb 2023

Study highlights the interconnectedness of autoimmunity and cancer

In a recent study published in the journal Immunity, researchers reviewed the T cell response in cancer and autoimmunity to propose strategies for more effective immunotherapies.

15 Feb 2023

Researchers find possible genetic basis and mouse model for nonalcoholic steatohepatitis

A mutant or damaged gene may be a cause of a severe, mysterious form of nonalcoholic fatty liver disease, University of Illinois Urbana-Champaign researchers have found.

9 Feb 2023

Recent therapeutic strategies for renal cell carcinoma and the effects of the tumor microenvironment on systemic therapy

Researchers explored the association between the human microbiome and improved renal cell carcinoma outcomes.

6 Feb 2023

Researchers devise a novel potential IBD treatment strategy that eliminates pathogenic T cells and encourages the proliferation of regulatory T cells

Researchers investigated the CAMCI strategy as an immunotherapeutic option for inflammatory bowel disease.

31 Jan 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Researchers use multiplexed 3D imaging to perform molecular and morphological assessments of colorectal cancers

Researchers used multiplexed and three-dimensional imaging with machine-based learning and spatial statistics to perform molecular and morphological assessments of colorectal cancers (CRC).

24 Jan 2023

Study shows spatial organization in tumor cells

Researchers investigated whether the observed tumor cellular heterogeneity and architecture result from stochastic and chaotic events, or whether there is more coordination in the histopathological chaos of cancer.

24 Jan 2023

What are the major findings of long COVID research?

Researchers explored existing literature on long coronavirus disease (COVID). They highlighted key immunological findings, similarities with other diseases, symptoms, and associated pathophysiological mechanisms, and diagnostic and therapeutic options, including COVID-19 vaccinations.

17 Jan 2023

Research suggests potential therapeutic avenues to enhance PD-1 immune checkpoint sensitivity

A new research paper was published in Oncotarget's Volume 13 on December 20, 2022, entitled, "Resistance of MMTV-NeuT/ATTAC mice to anti-PD-1 immune checkpoint therapy is associated with macrophage infiltration and Wnt pathway expression."

6 Jan 2023

Study investigates a new mechanism of pyrethroid derivatives-moderated programmed cell death

A new research paper was published in Oncotarget's Volume 13 on December 17, 2022, entitled, "The role of pyrethroid derivatives in autophagy and apoptosis crosstalk signaling and potential risk for malignancies."

29 Dec 2022