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Structure of protein methyltransferase from the monkeypox virus deciphered

Scientists from the Institute of Organic Chemistry and Biochemistry in Prague have deciphered the structure of the protein methyltransferase from the monkeypox virus

30 Apr 2023

Study uncovers new clues and raises more questions about CRISPR

CRISPR claimed scientific fame for its ability to quickly and accurately edit genes. But, at the core, CRISPR systems are immune systems that help bacteria protect themselves from viruses by targeting and destroying viral DNA and RNA.

27 Apr 2023

Researchers identify a druggable copper-signaling pathway that drives inflammation

Inflammation is a complex biological process that can eradicate pathogens and promotes repair of damaged tissues.

27 Apr 2023

Researchers uncover the molecular basis for making long-term memories

Helping your mother make pancakes when you were three…riding your bike without training wheels…your first romantic kiss: How do we retain vivid memories of long-ago events? As described in a paper published online on April 25 in Neuron, researchers at Albert Einstein College of Medicine have found the explanation.

25 Apr 2023

Revolutionizing Glycobiology: A Mass Spectrometrist's Perspective

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to Professor Albert Heck and gained a mass spectrometrist's perspective on the field of glycobiology.

From Pittcon 24 Apr 2023

New structural details of the COVID-19 virus revealed

A new study led by Worcester Polytechnic Institute (WPI) brings into sharper focus the structural details of the COVID-19 virus, revealing an elliptical shape that "breathes," or changes shape, as it moves in the body.

30 Mar 2023

Study may pave way for a more nuanced understanding of taste perception

Humans perceive five basic taste sensations: sweet, umami, bitter, salty, and sour. Specific foods trigger taste recognition of these sensations through the activation of different receptors in our taste buds.

23 Mar 2023

Understanding the structure of CFTR could help design more effective therapies for cystic fibrosis

Scientists at St. Jude Children's Research Hospital and Rockefeller University have combined their expertise to gain a better understanding of the cystic fibrosis transmembrane conductance regulator (CFTR).

23 Mar 2023

Structure of DREADD designer receptor could pave the way for creating next generation tools

In order to more fully understand how diseases arise in the brain, scientists must unravel the intricate way neurons relay messages (either chemical or electrical) along a complex web of nerve cells.

20 Feb 2023

Fluidic Analytics showcases protein analysis expertise across Europe

Fluidic Analytics Ltd, a pioneer in protein analysis and the company behind in-solution diffusional sizing, will attend a number of events this Autumn to showcase its revolutionary technology for studying protein interactions.

From Fluidic Analytics 8 Feb 2023

Professor Sara Linse presents new data on protein interactions in Alzheimer’s disease using the Fluidity One-W at FEBS 2019

Fluidic Analytics’ diffusional sizing technology has been influential in a recent study that investigates protein binding and self-assembly in Alzheimer’s disease.

From Fluidic Analytics 8 Feb 2023

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria.

3 Feb 2023

Research project aims to shed new light on how proteins in viruses bind to molecules

The way in which molecules interact forms the basis of life and treating illness. But what does it look like when a viral protein meets and binds to molecules like those found in medications? A new research project has been awarded DKK 65 million by the European Research Council and will now aim to shed light on this hitherto invisible process.

2 Feb 2023

Mays Cancer Center leads a study evaluating Phase I and Phase III clinical trials for breast cancer drug

The Mays Cancer Center, home to UT Health San Antonio MD Anderson Cancer Center, was the lead site for a study evaluating Phase I and Phase III clinical trials for elacestrant, a treatment for postmenopausal women and adult men with ER+/HER2- advanced or metastatic breast cancer.

1 Feb 2023

Atomic-level computer model of the H1N1 virus reveals new vulnerabilities

According to the World Health Organization, each year there are an estimated 1 billion cases of influenza, between 3-5 million severe cases and up to 650,000 influenza-related respiratory deaths globally.

25 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

Ubiquigent collaborates with University of Glasgow on translational structural biology to accelerate drug discovery within the (de)ubiquitylation field

Ubiquigent Limited (Ubiquigent), a drug discovery and development company harnessing novel deubiquitinase (DUB) modulators as new therapeutics for areas of high unmet medical need, today announced it is supporting a Master’s student at the University of Glasgow (UoG) to undertake a research project on USP30, a DUB implicated in neurodegenerative, renal, and cardiovascular diseases.

From Ubiquigent Limited 23 Jan 2023

New Pyk2-derived peptide inhibits breast cancer metastasis

An estimated ninety percent of deaths from breast cancer are due to complications resulting from metastasis, a process in which cancer cells break away from where they first formed, travel through the blood or lymph circulatory system, and form new, metastatic tumors in other parts of the body.

17 Jan 2023

Newly discovered CRISPR immune system shuts down infected cells to thwart infection

In this interview, News Medical speaks to Assitant Professor Ryan Jackson about his latest work, published in tandem Nature papers, detailing the discovery of a new CRISPR immune system.

11 Jan 2023

Anticancer drugs offer new hope for treatment of sepsis

Research led by the IGC reveals how these drugs limit inflammation, positioning them as potential treatments for sepsis.

10 Jan 2023