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Blood test detects early signs of liver transplant rejection

Liver transplant is a lifesaving surgery, but a significant number of patients experience organ rejection or other complications.

17 Jun 2025

Breakthrough therapy targets aggressive bladder cancer variant

Bladder tumors that have been excluded from clinical trials have a few things in common that could lead to new therapies.

17 Jun 2025

Estrogen-responsive cells found to heighten gut pain in females

Researchers uncovered how estrogen heightens gut sensitivity in females by activating PYY-secreting L-cells, which stimulate serotonin release from EC cells. This paracrine circuit intensifies pain signaling and may explain the sex bias in conditions like IBS.

16 Jun 2025

First patient treated in international clinical trial for rare muscle-weakness disease

The first patient enrolled in a planned international clinical trial has been treated at HonorHealth Research Institute with a new type of immune therapy for those with a rare muscle-weakness disease known as Myasthenia Gravis.

16 Jun 2025

Mitochondrial dysfunction drives cerebellar damage in multiple sclerosis

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement and balance, potentially leading to tremors, poor coordination, and trouble with motor control.

16 Jun 2025

Researchers identify a new treatment strategy for neuroblastoma

Researchers at Karolinska Institutet and Lund University in Sweden have identified a new treatment strategy for neuroblastoma, an aggressive form of childhood cancer.

16 Jun 2025

Immune tolerance to gut microbes depends on ancient protein STING

Thousands of bacterial and other microbial species live in the human gut, supporting healthy digestion, immunity, metabolism and other functions.

16 Jun 2025

New hereditary condition impairs DNA repair and raises blood cancer risk

A new hereditary condition has been discovered that affects patients' ability to repair DNA – leaving them both at greater risk of developing blood cancer, and unable to repair some of the damage caused by chemotherapy treatments.

16 Jun 2025

New computational tool uncovers hidden genetic mutations in proteins

Scientists at UCLA and the University of Toronto have developed an advanced computational tool, called moPepGen, that helps identify previously invisible genetic mutations in proteins, unlocking new possibilities in cancer research and beyond.

16 Jun 2025

Nanoneedle patch could replace painful traditional biopsies

A patch containing tens of millions of microscopic nanoneedles could soon replace traditional biopsies, scientists have found.

16 Jun 2025

Statins could reduce breast cancer mortality by a fifth

Research indicates statins could enhance breast cancer prognosis, with lipophilic statins showing greater protective effects against mortality and recurrence.

16 Jun 2025

FDA approval of pembrolizumab marks major shift in head and neck cancer treatment

Pembrolizumab, an immune checkpoint inhibitor, has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with resectable locally advanced head and neck squamous cell carcinoma whose tumors express PD-L1 [Combined Positive Score (CPS) ≥1] as determined by an FDA-approved test.

15 Jun 2025

Deep B cell depletion offers new hope for rheumatologic and musculoskeletal diseases

CD19-CAR T-cell treatment is a novel option of deep B cell depletion with promising results across different rheumatologic and musculoskeletal diseases (RMD).

15 Jun 2025

Rapid generation of functional blood vessels from human stem cells

Blood vessels are essential to nearly all tissues, delivering nutrients and oxygen, regulating hemostasis, and modulating inflammation.

14 Jun 2025

c-Fos exhibits a dual role in memory formation and Alzheimer's disease

Immediate-early genes (IEGs), including c-Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural activity, synaptic plasticity, and stress responses.

14 Jun 2025

BRCA mutations sharply increase risk of implant-associated lymphoma

Women with breast cancer who were also carriers of the BRCA1 or BRCA2 mutation and received textured breast implants as part of their reconstructive surgery after mastectomy were 16 times more likely to develop breast implant-associated anaplastic large cell lymphoma (BIA-ALCL), a rare T-cell lymphoma, compared with similar women without these genetic mutations, according to a study published today in Blood Advances.

14 Jun 2025

Researchers identify cellular hotspots that trigger ferroptosis

Researchers at the VIB-KU Leuven Center for Cancer Biology have uncovered how a unique interaction between two cellular compartments, namely the endoplasmic reticulum (ER) and mitochondria, can act as a central ignition point for ferroptosis, a form of cell death driven by lipid oxidation and iron.

14 Jun 2025

New nanoparticle platform breaks through MRSA biofilms

A major cause of hospital-acquired infections, the super bacteria Methicillin-resistant Staphylococcus aureus (MRSA), not only exhibits strong resistance to existing antibiotics but also forms a dense biofilm that blocks the effects of external treatments.

14 Jun 2025

Understanding the role of astrocytes in depression and neuroinflammation

Major depressive disorder (MDD) is a mental health condition that negatively affects the mood of a person and causes a loss of interest in activities that were previously associated with happiness.

13 Jun 2025

RNA steps up to protect the genome from DNA knots

Not all DNA looks like the familiar twisted ladder. Sometimes, parts of our genetic code fold into unusual shapes. One such structure, the G-quadruplex (G4), looks like a knot.

13 Jun 2025