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Study finds factors contributing to drug abuse among disadvantaged, rural youth

Having grown up poor in a rural village in Zimbabwe, Wilson Majee saw firsthand as a child the lack of educational opportunities that were easily accessible and how that impacted the youth in his village.

27 Apr 2021

Household aerosols now emit more harmful volatile organic compound air pollution than all UK vehicles

Aerosol products used in the home now emit more harmful volatile organic compound (VOC) air pollution than all the vehicles in the UK, new research shows.

27 Apr 2021

Research suggests that Ginkgo biloba extract contains naturally occurring inhibitors against SARS-CoV-2

Researchers at Shihezi University in China found that Gingko Biloba leaves extract contains the most potent SARS-CoV-2 3-Chymotrypsin-like protease (3CLpro). This virally encoded main proteinase is essential for viral replication in coronaviruses.

27 Apr 2021

Researchers examine potential SARS-CoV-2 antivirals using a drug repurposing library

A new study deals with the screening of the Drug Repurposing Hub (DRH) library for identifying small compounds which are capable of inhibiting SARS-CoV-2 using both in vitro and in vivo experimental studies. These molecules could be used for designing a novel therapeutic system against SARS-CoV-2 infection.

26 Apr 2021

Two repurposed drugs and a blue dye show potential as SARS-CoV-2 entry inhibitors

A new multidisciplinary study from Australia, published in the open-access journal mBio, shows that three compounds used to treat cystic fibrosis, dry eye, and a specific medical dye may lead to future strategies for the treatment of coronavirus disease (COVID-19).

25 Apr 2021

Only one vaccine is OK for older teens. It’s also the hardest to manage in rural America.

As states expand covid-19 vaccine eligibility to allow shots for 16- and 17-year-olds, teens in rural America may have trouble getting them.

23 Apr 2021

Drug-discovery collaboration finds potential new antimalarial drug candidates

Potential new antimalarial drug candidates are being developed through an extended drug-discovery collaboration between Australian medical research institute WEHI and Janssen Pharmaceutica NV. The collaboration was facilitated by Johnson & Johnson Innovation.

22 Apr 2021

Babies born to mothers with cannabis use disorder more likely to experience negative health outcomes

A study of almost 5 million live births in California by researchers at the Herbert Wertheim School of Public Health and Human Longevity Science at University of California San Diego reports that babies born to mothers diagnosed with cannabis use disorder were more likely to experience negative health outcomes, such as preterm birth and low birth weight, than babies born to mothers without a cannabis use disorder diagnosis.

22 Apr 2021

Clinical trial examines metabolic effects of natural compound NMN in people

A natural compound previously demonstrated to counteract aspects of aging and improve metabolic health in mice has clinically relevant effects in people, according to new research at Washington University School of Medicine in St. Louis.

22 Apr 2021

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Researchers at Albert Einstein College of Medicine have designed an experimental drug that reversed key symptoms of Alzheimer's disease in mice.

22 Apr 2021

Animal study shows how chemical compound in Indian Long Pepper works against glioblastoma

Piperlongumine, a chemical compound found in the Indian Long Pepper plant (Piper longum), is known to kill cancerous cells in many tumor types, including brain tumors.

21 Apr 2021

Can sniffer dogs be trained to detect SARS-CoV-2 infection?

A new study in PLOS ONE discusses the novel use of dogs to sniff out the virus in patient samples as a potential additional diagnostic route to ease the situation.

21 Apr 2021

Asymmetric technique to synthesize aziridines in the presence of newly developed catalysts

Unless you've studied chemistry in college, it's unlikely you've come across the name aziridine. An organic compound with the molecular formula, C2H4NH, aziridines are well-known among medicinal chemists, who make use of the compound to prepare pharmaceutical drugs such as Mitomycin C, a chemotherapeutic agent known for its anti-tumor activity.

20 Apr 2021

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

A chemist from Purdue University has found a way to synthesize a compound to fight a previously "undruggable" cancer protein with benefits across a myriad of cancer types.

20 Apr 2021

Can an immunosuppressive cancer drug promote SARS-CoV-2 entry into host cells?

A new study shows that rapamycin, an immunosuppressive drug used in some cancers, and its analogs, may have an undesirable effect on viral entry into the host cells. This finding could inform their use to treat symptomatic COVID-19.

20 Apr 2021

Could virosome-based nanovaccines be a promising new approach to preventing viral diseases?

A recent review in the International Journal of Biological Macromolecules provides a novel overview of 'virosome'-based nanovaccine production, its properties, and its application in viral diseases, emphasizing its importance in SARS-CoV-2 vaccine discovery.

20 Apr 2021

Gender parity in orthopaedic surgery requires substantive changes to improve the current curve

At the current rate of change, it will take more than 200 years for the proportion of women in orthopaedic surgery to reach parity with the overall medical profession.

20 Apr 2021

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

The lack of new or repurposed drugs to treat patients with severe or critical COVID-19 has been one of the biggest hurdles to reducing mortality rates in the ongoing pandemic caused by SARS-CoV-2. A new study describes the potential for the use of the plant molecule isorhamnetin in the management of this virus.

19 Apr 2021

Three teams selected to receive the first awards from Dartmouth Innovations Accelerator for Cancer

Three teams of Dartmouth researchers have been selected to receive the first awards from the Dartmouth Innovations Accelerator for Cancer.

17 Apr 2021

Novel PET radiopharmaceutical shows promising results in first-in-humans study

The preliminary trial results of a novel radiopharmaceutical for PET imaging of inflammation developed at the University of Turku, Finland, have been published.

16 Apr 2021

Compound News and Research

Study finds factors contributing to drug abuse among disadvantaged, rural youth

Household aerosols now emit more harmful volatile organic compound air pollution than all UK vehicles

Research suggests that Ginkgo biloba extract contains naturally occurring inhibitors against SARS-CoV-2

Researchers examine potential SARS-CoV-2 antivirals using a drug repurposing library

Two repurposed drugs and a blue dye show potential as SARS-CoV-2 entry inhibitors

Only one vaccine is OK for older teens. It’s also the hardest to manage in rural America.

Drug-discovery collaboration finds potential new antimalarial drug candidates

Babies born to mothers with cannabis use disorder more likely to experience negative health outcomes

Clinical trial examines metabolic effects of natural compound NMN in people

Experimental drug reverses key symptoms of Alzheimer's disease in mice

Animal study shows how chemical compound in Indian Long Pepper works against glioblastoma

Can sniffer dogs be trained to detect SARS-CoV-2 infection?

Asymmetric technique to synthesize aziridines in the presence of newly developed catalysts

Rare compound found in a shrub could help fight previously 'undruggable' cancer protein

Can an immunosuppressive cancer drug promote SARS-CoV-2 entry into host cells?

Could virosome-based nanovaccines be a promising new approach to preventing viral diseases?

Gender parity in orthopaedic surgery requires substantive changes to improve the current curve

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

Three teams selected to receive the first awards from Dartmouth Innovations Accelerator for Cancer

Novel PET radiopharmaceutical shows promising results in first-in-humans study

Enhancing confidence in chemical ionization spectrometry data eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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