Mouse Model News and Research

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A ferry protein in the pancreas safeguards beta-cells from high-fat diet induced stress

Every time we eat, the glucose level in our body goes up. This spurs our pancreatic machinery into action and through intricate physiological mechanisms, appropriate amounts of insulin are produced, our blood glucose levels are controlled, and we remain healthy.

16 Sep 2020

Researchers reveal neurons responsible for guiding adaptive behavior

Humans, like other animals, have the ability to constantly adapt to new situations. Researchers at the Brain Research Institute of the University of Zurich have utilized a mouse model to reveal which neurons in the brain are in command in guiding adaptive behavior.

16 Sep 2020

Study reveals damaging role of immune system in severe brain infection

A new study has detailed the damaging role played by the immune system in a severe brain condition most commonly caused by the cold sore virus.

15 Sep 2020

New biomarker can reliably predict aggressiveness of biliary tract cancer

The cancer called biliary tract cancer (BTC) is not the most widespread form of cancer. In western countries, about 1.6 in 100.000 gets the diagnose every year. It is, however, a very aggressive form of cancer.

15 Sep 2020

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

Scientists at Sanford Burnham Prebys Medical Discovery Institute, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore in Rome have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring (fibrosis).

15 Sep 2020

Scientists unlock crucial molecular details regarding tau's activity

Frontotemporal lobar degeneration (FTLD) is a type of dementia that appears earlier in life than Alzheimer's disease (AD).

15 Sep 2020

Central nervous system immune responses to COVID-19

A recent study published on the preprint server bioRxiv by scientists from Yale School of Medicine, University of California, Yale School of Public Health, Yale University, and Howard Hughes Medical Institute examined the impact of SARS-CoV-2 infection on the central nervous system.

14 Sep 2020

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Myotonic dystrophy type I is the most common type of adult-onset muscular dystrophy. People with the condition inherit repeated DNA segments that lead to the toxic buildup of repetitive RNA, the messenger that carries a gene's recipe to the cell's protein-making machinery.

14 Sep 2020

Keto diet could be beneficial for elderly COVID-19 patients

A recent study by researchers at Yale School of Medicine, New York University Langone Health and Washington University School of Medicine, claims that the ketogenic diet (high fat, low carbohydrate diet) is capable of mitigating clinical outcomes of coronavirus disease 2019 (COVID-19) in elderly people by improving immune-metabolic functions and reducing inflammation. The study is currently available on the bioRxiv* preprint server.

14 Sep 2020

Prolonged isolation can induce bone loss in humans

Clinical studies have found that bone mineral density in patients with anxiety or depression is lower than in ordinary people.

11 Sep 2020

Novel liver cancer treatment could shrink tumors in a mouse model

Hepatocellular carcinoma is a common liver cancer with poor prognosis. With symptoms not discovered until later stages, it is considered the most fatal malignant liver cancer worldwide.

10 Sep 2020

Researchers identify proinflammatory lipids that precede onset of Type 1 diabetes in mouse model, children

Type 1 diabetes, or T1D, is an autoimmune disease in which the body's immune cells - led by inflammatory macrophages - attack and destroy the beta cells of the pancreas that produce insulin.

10 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.

8 Sep 2020

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

An investigational drug that targets an instigator of the TDP-43 protein, a well-known hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), may reduce the protein's buildup and neurological decline associated with these disorders, suggests a pre-clinical study from researchers at Penn Medicine and Mayo Clinic.

8 Sep 2020

Mouse Model News and Research

A ferry protein in the pancreas safeguards beta-cells from high-fat diet induced stress

Researchers reveal neurons responsible for guiding adaptive behavior

Study reveals damaging role of immune system in severe brain infection

New biomarker can reliably predict aggressiveness of biliary tract cancer

Study uncovers a promising new therapeutic approach for Duchenne muscular dystrophy

Scientists unlock crucial molecular details regarding tau's activity

Central nervous system immune responses to COVID-19

RCas9 gene therapy clears toxic RNA buildup in mouse model of myotonic dystrophy

Keto diet could be beneficial for elderly COVID-19 patients

Prolonged isolation can induce bone loss in humans

Novel liver cancer treatment could shrink tumors in a mouse model

Researchers identify proinflammatory lipids that precede onset of Type 1 diabetes in mouse model, children

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Investigational drug may reduce protein buildup and neurological decline linked to ALS, FTD

Lack of oxygen can trigger tumor metastases

A potential new way of treating Alzheimer’s Disease

Researchers identify biomarkers associated with bacterial infection mortality

Tiny hydrogel capsule delivers anti-rejection drug to area surrounding a grafted heart

Study provides direct link between inflammation and Alzheimer’s plaque development

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