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Researchers create largest publicly available virtual library of macrolide scaffolds

Researchers from North Carolina State University have created the largest publicly available virtual library of macrolide scaffolds. The library - called V1M - contains chemical structures and computed properties for 1 million macrolide scaffolds with potential for use as antibiotics or cancer drugs.

29 Nov 2018

Researchers discover pathway for enhancing the self-repair efforts of injured kidneys

A team of researchers led by Jonathan Stamler, MD, of Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, has discovered a pathway for enhancing the self-repair efforts of injured kidneys.

29 Nov 2018

New ointment for treating brown recluse spider bites is tested on humans

The bite from a brown recluse spider (Loxosceles) can cause skin necrosis, renal failure, and even death. A new ointment is being tested in Brazil, however. Its effects have already been proven in tests conducted in cell cultures and animal models.

29 Nov 2018

New study solves longstanding mystery in innate immunity

UT Southwestern biochemist and Breakthrough Prize winner Dr. Zhijian "James" Chen's newest study answers a long-standing question in the field of innate immunity.

29 Nov 2018

Antibiotic could protect against age-related brain diseases

An antibiotic, minocycline, can increase the lifespan of roundworms by preventing the build-up of proteins during aging, a study in the open-access journal eLife reports.

28 Nov 2018

New antibody can reduce swelling attacks in patients with hereditary angioedema

Patients with hereditary angioedema experience recurrent and sometimes life-threatening swelling attacks. Researchers from Charité - Universitätsmedizin Berlin have tested an antibody capable of reducing the frequency of these swelling attacks by more than 90 percent.

28 Nov 2018

Researchers regrow hair strands on damaged skin

By stirring crosstalk among skin cells that form the roots of hair, researchers report they have regrown hair strands on damaged skin. The findings better explain why hair does not normally grow on wounded skin, and may help in the search for better drugs to restore hair growth, say the study's authors.

28 Nov 2018

Study uncovers new chemical reaction key to cataract formation

Researchers working to understand the biochemistry of cataract formation have made a surprising finding: A protein that was long believed to be inert actually has an important chemical function that protects the lens of the eye from cataract formation.

28 Nov 2018

Discovery about DNA twists could be crucial in development of new antibiotics

DNA replication is vital to all lifeforms, but in some organisms, it can be prevented by twists in the DNA sequence, called 'supercoils'. If too many supercoils are allowed to build up, cells vital to sustaining life will die.

28 Nov 2018

UT Southwestern researchers discover enzyme that promotes tumor growth

UT Southwestern researchers have found that an enzyme on the surface of some lung cancer cells helps feed the cancer, making it a tempting treatment target.

28 Nov 2018

Scientists identify clues to brain changes in depression

In new pre-clinical research, scientists at the University of Maryland School of Medicine, led by Scott Thompson, PhD, Professor of Physiology, have identified changes in brain activity linked to the pleasure and reward system.

28 Nov 2018

Research reveals how a small molecule helps remove excess cholesterol

Scientists have determined the structure of the activated form of an enzyme that helps to return excess cholesterol to the liver, a study in eLife reports.

27 Nov 2018

Scientists pinpoint protein that plays key role in synovial sarcoma tumors

Researchers have pinpointed a protein that plays a key role in a type of rare cancer often leading to tumours around joints and tendons, according to new findings in eLife.

27 Nov 2018

Blood-suckers carrying malaria parasites can be traced back up to 100 million years

The microorganisms that cause malaria, leishmaniasis and a variety of other illnesses today can be traced back at least to the time of dinosaurs, a study of amber-preserved blood-sucking insects and ticks show.

27 Nov 2018

Discovery could be used to prevent viral infection and autoimmunity

Researchers have discovered that chemical changes to mRNA regulate the production of interferon beta, and hope to exploit this in new treatments.

27 Nov 2018

Scientists discover important hallmark of aging in neuronal cells

MIT researchers have discovered that free radicals cause a build-up of short RNA snippets which could contribute to neuronal ageing and cognitive decline.

27 Nov 2018

Scientists report novel combination transport system in E. coli

A general concept in biology is that cells use two different systems to transport substances across their membrane: selective pores, which allow passive transport driven by a concentration gradient, and active transport complexes, which use energy to transport substances against a gradient.

27 Nov 2018

Study reveals mechanism by which malaria parasite converts from its asexual to sexual form

A study led by the Barcelona Institute for Global Health (ISGlobal) - an institution supported by "la Caixa" Foundation- reveals a new mechanism by which the malaria parasite Plasmodium falciparum converts from its asexual to its sexual form, which can be transmitted to the mosquito.

27 Nov 2018

Study provides insights into the mechanism of Gip1 interaction with G proteins

Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical signals.

27 Nov 2018

Research may pave way for development of potent weapons against cancer

Despite significant advances in cancer research, the disease continues to exact a devastating toll. Because cancer is a disease of the body's own cells, which mutate and develop under evolutionary pressure, conventional treatments like chemotherapy and radiation often leave behind a residue of resistant cells that go on to expand and wreak havoc.

27 Nov 2018