G Protein News and Research

RSS

75% of hospital patients suffer from malnutrition regardless of their pathology

A study of 817 patients conducted in the Department of Nutrition and Bromatology at the University of Granada (UGR), in collaboration with the Unit of Nutrition and Dietetics at the hospital Virgen de las Nieves (Granada, Spain) of 817 patients, showed that 75% of hospitalised patients suffer from malnutrition regardless of their pathology.

24 Oct 2007

Potent inhibitor of Kinesin CENP-E demonstrates tumor cell inhibition

A first-in-class, targeted investigational therapy specifically designed to inhibit a single protein that functions only during cell division shows potent activity in a broad range of cancer cell lines, say researchers from GlaxoSmithKline.

24 Oct 2007

Legionnaire's bacterial proteins work together to survive

Proteins within the bacteria that cause Legionnaire's disease can kidnap their own molecular "coffin" and carry it to a safe place within the cell, ensuring their survival, Yale School of Medicine researchers report in Nature Wednesday.

24 Oct 2007

Experimental cancer pharmaceuticals under trial

A potent and selective inhibitor of the mitotic kinesin CENP-E (GSK923295A) demonstrates a novel mechanism of inhibiting tumor cell proliferation and shows activity against a broad panel of human tumor cell lines in vitro: Abstract A 111.

24 Oct 2007

Advances in drug screening

With the discovery of suitable molecular targets - cellular molecules along pathways crucial for sustaining the life of cancer cells - comes the perplexing dilemma of where to find the next therapeutics that will bind to and disable those targets.

23 Oct 2007

Cellular power plant fault explains abnormal metabolism of tumours

The increased consumption of glucose that tumour cells exhibit, was thought to be a cause of the extra demand of building blocks required to keep up with an uncontrolled cell growth, but now it is more accepted that it could be the effect of a programmed metabolic change that favours this malignant growth.

23 Oct 2007

75% of hospitalised patients suffer from malnutrition regardless of their pathology

23 Oct 2007

Transparent zebrafish help the study inflammatory breast cancer

What if doctors could peer through a patient's skin and see a cancer tumor growing? They'd be able to study how tumor cells migrate: how they look, how they interact with the blood system to find nourishment to grow and spread through the body.

22 Oct 2007

Study explains why physical activity is beneficial in preventing heart attack and stroke

It is well known that physical activity can improve cardiovascular health. But it's the impact exercise has on specific known risk factors that accounts for about 60 percent of that improvement, researchers reported in Circulation: Journal of the American Heart Association.

22 Oct 2007

Severely restricting calories leads to a longer life

New research now has shown for the first time that such a diet also can maintain physical fitness into advanced age, slowing the seemingly inevitable progression to physical disability and loss of independence.

22 Oct 2007

Scientists uncover how hormones achieve their effects

The first quantitative study of protein complexes that transmit pheromone signals in living yeast cells sheds light on a crucial signalling process also found in humans.

22 Oct 2007

Heparanase shows potential as cancer drug

Laboratory experiments have previously shown that cancer cells overproduce an enzyme, heparanase, which splits the body's own polysaccharide heparan sulfate into shorter fragments.

22 Oct 2007

The biomedical and sociological effects of sleep restriction

In spring 2005 a large European research and training network was established to investigate the causes and implications of poor sleep from a medical as well as from a social point of view. This EU-financed sleep research project, “The biomedical and sociological effects of sleep restriction”, is coordinated by Dr. Tarja Porkka-Heiskanen (Stenberg) MD, PhD, at the University of Helsinki, Institute of Biomedicine.

22 Oct 2007