Protein C News and Research

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Surprising discovery about BH4 may rekindle interest in once-promising pathway

In 2013, renowned Boston Children's Hospital pain researcher Clifford Woolf, MB, BCh, PhD, and chemist Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief.

19 Nov 2018

Scientists discover new inhibitor that decreases lung inflammation

Scientists from the University of Sheffield have discovered a new inhibitor which decreases lung inflammation and could hold the key to treating Acute Respiratory Distress Syndrome - a life-threatening disease which affects thousands of people in the UK.

18 Nov 2018

New strategy to hinder emergence of antimicrobial-resistant pathogens

With many disease-causing bacteria ratcheting up their shields against current drugs, new tactics are vital to protect people from treatment-resistant infections.

17 Nov 2018

New model of FSHD could be useful to study effectiveness of experimental therapeutics

Facioscapulohumeral muscular dystrophy is the most prevalent dominantly inherited muscular dystrophy in the world. To date, there are no pharmacologic treatments available for the more than 850,000 people affected worldwide.

17 Nov 2018

New method to analyze cell membrane complexes could revolutionize the way we study diseases

Researchers have developed a new technique to analyze cell membrane proteins in situ which could revolutionize the way in which we study diseases, such as cancer, metabolic and heart diseases.

17 Nov 2018

Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission

During a heart attack the supply of oxygen to heart cells is decreased. This reduced oxygen level, called hypoxia, causes the cell's powerhouses, the mitochondria, to fragment, impairing cell function and leading to heart failure. Until now, few details were known on how this important process occurs.

17 Nov 2018

New first-line treatment for peripheral T-cell lymphoma approved by FDA

The U.S. Food and Drug Administration today expanded the approved use of Adcetris (brentuximab vedotin) injection in combination with chemotherapy for adult patients with certain types of peripheral T-cell lymphoma.

16 Nov 2018

Using light to control crucial step in embryonic development

In optogenetics, researchers use light to control protein activity. This technique allows them to alter the shape of embryonic tissue and to inhibit the development of abnormalities.

16 Nov 2018

Mechanisms that govern HIV latency differ in the gut and blood, finds study

Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published November 15 in the open-access journal PLOS Pathogens by Steven Yukl of San Francisco Veterans Affairs Medical Center and the University of California, San Francisco, and colleagues.

16 Nov 2018

Drug used to treat dizziness may slow down growth of triple-negative breast cancer

Screening Food and Drug Administration approved compounds for their ability to stop cancer growth in the lab led to the finding that the drug flunarizine can slow down the growth of triple-negative breast cancer in an animal model of the disease.

16 Nov 2018

Game-Changers in Western Blotting and Protein Analysis

An interview with Ramya Prabakaran & Melody Chang from GenScript, discussing the development of automated systems that improve outcomes for western blotting.

From GenScript 16 Nov 2018

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

A protein with a role in sensing cell damage and viral infections is a new target for the treatment of pulmonary hypertension, or increased blood pressure in the lungs, according to research led by Virginia Commonwealth University and the University of Sheffield in the United Kingdom.

16 Nov 2018

New approach allows pathogens to be starved by blocking important enzymes

More and more bacteria are resistant to available antibiotics. A team of chemists from the Technical University of Munich now presents a new approach: they have identified important enzymes in the metabolism of staphylococci. Blocking these enzymes in a targeted manner would allow the pathogens to be starved.

15 Nov 2018

Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome

Over 30 years ago, Marsha and Allen Barnett lost their sons to a puzzling childhood disease that relentlessly attacked their nervous systems and sapped their energy.

15 Nov 2018

Researchers develop new drug molecule that inhibits inflammation

A multidisciplinary team of researchers led from Karolinska Institutet in Sweden have developed an anti-inflammatory drug molecule with a new mechanism of action.

15 Nov 2018

Non-coding genetic variant plays key role in endothelial function and disease incidence

Atherosclerotic disease, the slow and silent hardening and narrowing of the arteries, is a leading cause of mortality worldwide. It is responsible for more than 15 million deaths each year, including an estimated 610,000 people in the United States.

15 Nov 2018

Protein in cell membranes of sperm plays key role in finding their way to eggs

Researchers have found that a protein in the cell membranes of sperm plays a key role in how they find their way to eggs.

15 Nov 2018

Researchers uncover how insect antibiotic targets Gram-negative bacteria

An antibiotic called thanatin attacks the way the outer membrane of Gram-negative bacteria is built. Researchers at the University of Zurich have now found out that this happens through a previously unknown mechanism. Thanatin, produced naturally by the spined soldier bug, can therefore be used to develop new classes of antibiotics.

15 Nov 2018

Scientists try to develop portable systems that can quickly produce biologics on demand

Many life-saving medicines, including insulin, antibodies and vaccines, are derived from living cells. These "biologics" can be difficult to obtain and store on the battlefield or in remote areas.

15 Nov 2018

Hot water treatment may help improve inflammation and metabolism in sedentary people

Hot water treatment may help improve inflammation and blood sugar (glucose) levels in people who are unable to exercise, according to a new study. The findings are published ahead of print in the Journal of Applied Physiology.

15 Nov 2018

Protein C News and Research

Surprising discovery about BH4 may rekindle interest in once-promising pathway

Scientists discover new inhibitor that decreases lung inflammation

New strategy to hinder emergence of antimicrobial-resistant pathogens

New model of FSHD could be useful to study effectiveness of experimental therapeutics

New method to analyze cell membrane complexes could revolutionize the way we study diseases

Researchers show how proteins interact in hypoxic conditions to facilitate mitochondrial fission

New first-line treatment for peripheral T-cell lymphoma approved by FDA

Using light to control crucial step in embryonic development

Mechanisms that govern HIV latency differ in the gut and blood, finds study

Drug used to treat dizziness may slow down growth of triple-negative breast cancer

Game-Changers in Western Blotting and Protein Analysis

Protein which plays role in sensing cell damage serves as new target to treat pulmonary hypertension

New approach allows pathogens to be starved by blocking important enzymes

Research team identifies Ashkenazi Jewish founder mutation for Leigh syndrome

Researchers develop new drug molecule that inhibits inflammation

Non-coding genetic variant plays key role in endothelial function and disease incidence

Protein in cell membranes of sperm plays key role in finding their way to eggs

Researchers uncover how insect antibiotic targets Gram-negative bacteria

Scientists try to develop portable systems that can quickly produce biologics on demand

Hot water treatment may help improve inflammation and metabolism in sedentary people

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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