Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

New oncogene may contribute to high incidence of prostate cancer among African American men

A team of scientists has identified MNX1 as a new oncogene - a gene than can cause cancer - that is more active in African American prostate cancer than in European American prostate cancer.

21 Oct 2016

Yale researchers develop new mouse model to understand multiple myeloma

Understanding how multiple myeloma develops and responds to therapies may be easier using a new mouse model developed at Yale University School of Medicine.

21 Oct 2016

Study reveals promising new strategy to treat birth defect in boys

A study published in Scientific Reports describes a potential new strategy that may be utilized to correct hypospadias, a birth defect which occurs when boys are born with a urinary opening on the underside of the penis, found in up to one in every 200 boys.

21 Oct 2016

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Leukocytes which arise during the embryonic period regulate iron metabolism and the growth of the mammary gland in adults.

17 Oct 2016

Penn researchers identify new immune system mechanism to fight against infections

The innate immune system serves as a first-line defense, responding to infections almost immediately after a pathogen makes its way into the body.

17 Oct 2016

Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

The National Institutes of Health National Heart, Lung and Blood Institute has awarded a $2.4 million grant over four years to Cleveland Clinic cancer researchers Jaroslaw Maciejewski, M.D., and Richard Padgett, Ph.D., to test the hypothesis that alterations in the pattern of splicing of target genes play a major role in the establishment or progression of myelodysplastic syndromes (MDS).

14 Oct 2016

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $10 million from the National Cancer Institute to explore the cellular and molecular mechanisms of acute graft-versus-host disease (GVHD), a common side effect that occurs after allogeneic bone marrow transplantation (BMT), and to develop novel therapeutic strategies for BMT patients with cancer that begin in the cells of blood-forming tissue or hematologic malignancies.

13 Oct 2016

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

A team of physicians and laboratory scientists has taken a key step toward a cure for sickle cell disease, using CRISPR-Cas9 gene editing to fix the mutated gene responsible for the disease in stem cells from the blood of affected patients.

12 Oct 2016

Study finds new therapeutic target to prevent progression of rare blood cancer

In a laboratory study, Upstate Medical University researcher Golam Mohi, Ph.D., his graduate student Yue Yang, and colleagues, have found that the loss of gene EZH2 promotes the development of Myelofibrosis (MF) in mice.

7 Oct 2016

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata--an autoimmune disease that causes patchy, and less frequently, total hair loss--had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

5 Oct 2016

Researchers discover how signals from infectious bacteria get to inflammasome sensors

Researchers at St. Jude Children's Research Hospital have discovered the way signals from infectious bacteria gain entry into the cytoplasm of host cells to activate disease-fighting inflammasomes.

29 Sep 2016

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy.

27 Sep 2016

JAK inhibitors may be first effective treatment for people with alopecia areata

Seventy-five percent of patients with moderate to severe alopecia areata—an autoimmune disease that causes patchy, and less frequently, total hair loss—had significant hair regrowth after treatment with ruxolitinib, reported researchers from Columbia University Medical Center. By the end of their treatment, average hair regrowth was 92 percent.

22 Sep 2016

Novel immunotherapy shows promise against AML in clinical trial

A new type of immunotherapy shows promise against cases of acute myeloid leukemia (AML) that recur after treatment or that never respond to therapy in the first place.

21 Sep 2016

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

The National Heart, Lung, and Blood Institute, part of the National Institutes of Health, has awarded a 6-year, $4.4 million grant to St. Jude Children's Research Hospital and collaborators to improve the use of prescribed medication by sickle cell patients.

21 Sep 2016

Real-time MRI guidance could help target and deliver stem cell therapies

Working with animals, a team of scientists reports it has delivered stem cells to the brain with unprecedented precision by threading a catheter through an artery and infusing the cells under real-time MRI guidance.

14 Sep 2016

Discovery of immune antibody could lead to development of improved influenza vaccines

Dana-Farber Cancer Institute investigators report they have discovered a type of immune antibody that can rapidly evolve to neutralize a wide array of influenza virus strains - including those the body hasn't yet encountered.

14 Sep 2016

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

In a paper published today in Science Translational Medicine, researchers from Fred Hutchinson Cancer Research Center shared data from an early-phase study of patients with advanced non-Hodgkin lymphoma (NHL) who received JCAR014, a Chimeric Antigen Receptor (CAR) T cell treatment, and chemotherapy.

9 Sep 2016

UC researchers offer more insights into how lack of gut bacteria influences fat absorption

A study led by University of Cincinnati lipid metabolism researchers lends additional insight into how bacteria in the gut, or lack thereof, influences intestinal mast cells (MMC) activation and perhaps fat absorption.

9 Sep 2016

Researchers reveal potential therapeutic treatment for alphavirus infections

Research conducted by Griffith University and Melbourne-based company Paradigm Biopharmaceuticals Limited has uncovered a potential new therapeutic treatment for the global battle against mosquito-borne alphavirus infections, including the debilitating Ross River Virus (RRV) and Chikungunya Virus (CHIKV).

8 Sep 2016

Bone Marrow News and Research

Further Reading

New oncogene may contribute to high incidence of prostate cancer among African American men

Yale researchers develop new mouse model to understand multiple myeloma

Study reveals promising new strategy to treat birth defect in boys

Finnish researchers identify molecular mechanism that controls migration of early macrophages

Penn researchers identify new immune system mechanism to fight against infections

Cleveland Clinic cancer researchers receive $2.4 million grant from NIH NHLBI

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Genome engineering-based methods pave way for new treatment of patients with sickle cell disease

Study finds new therapeutic target to prevent progression of rare blood cancer

JAK inhibitors show promise in restoring hair growth in patients with alopecia areata

Researchers discover how signals from infectious bacteria get to inflammasome sensors

Researchers identify new immune cell that protects mice from lung infections during chemotherapy

JAK inhibitors may be first effective treatment for people with alopecia areata

Novel immunotherapy shows promise against AML in clinical trial

New mobile health app may help manage hydroxyurea treatments in sickle cell patients

Real-time MRI guidance could help target and deliver stem cell therapies

Discovery of immune antibody could lead to development of improved influenza vaccines

Right dose of CAR T cells and lymphodepletion can achieve good response rates for NHL patients

UC researchers offer more insights into how lack of gut bacteria influences fat absorption

Researchers reveal potential therapeutic treatment for alphavirus infections

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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