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Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

26 Aug 2016

Gene fusions in esophageal adenocarcinomas offer new molecular insights into lethal cancer

Despite years of research, cellular mechanisms contributing to cancers like esophageal adenocarcinoma have remained elusive.

26 Aug 2016

Stem cells contribute to origin of cancer in different organs of mice

The idea that stem cells - special cells that divide to repair and generate tissues - might be the major determinant of cancer risk has provoked great debate in the scientific community.

25 Aug 2016

Advances in brain research since patient HM: an interview with Dr Jacopo Annese

Jacopo Annese, President and CEO of the Institute for Brain and Society, discusses his work on the Human Brain Library.

From Huron Technologies 25 Aug 2016

Three like-minded nonprofits collaborate to launch immunotherapy clinical trial for pediatric brain tumors

A Kids' Brain Tumor Cure Foundation, Solving Kids' Cancer and the Ty Louis Campbell Foundation announce their joint financial support of a Phase 1 clinical trial to test the safety and efficacy of combination checkpoint inhibitors in the treatment of children with brain tumors.

25 Aug 2016

Study shows lymph node stage may have clinical importance among NSCLC patients with M1a disease

Analysis of a large non-small cell lung cancer (NSCLC) patient cohort with stage IV M1a disease identified lymph node staging as having clinical significance and an impact on prognosis.

25 Aug 2016

New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

A novel MRI method that detects low levels of zinc ion can help distinguish healthy prostate tissue from cancer, UT Southwestern Medical Center radiologists have determined.

23 Aug 2016

Fruit fly models may help scientists understand underlying mechanism of HPV-induced cancer

Human papillomavirus (HPV) is one of the most common sexually transmitted infections in the United States and has been identified as a primary cause of cervical cancer in women.

19 Aug 2016

New research reveals vanity could play crucial role in protecting young women from harmful UV light

New research published in Cogent Psychology, examines the way sun safe messages are conveyed to young women, and reveals their vanity could play a vital role in protecting them from harmful UV light.

18 Aug 2016

Research findings open avenues for creating new classes of anticancer drugs

A new study at Los Alamos National Laboratory and in collaboration with Stanford Synchrotron Radiation Lightsource greatly improves scientists' understanding of the element actinium. The insights could support innovation in creating new classes of anticancer drugs.

18 Aug 2016

Young adult women support stricter regulations, but against total ban of indoor tanning

Most young adult women who regularly visit indoor tanning salons support the introduction of policies to make it safer, but are against a total ban. This is according to a study led by Darren Mays of Georgetown University Medical Center in the US, in the journal Translational Behavioral Medicine: Practice, Policy, Research, published by Springer.

17 Aug 2016

New study uncovers how chromosomal changes impact tumor formation and growth

As with most cancers, triple-negative breast cancer (TNBC) cells have abnormal amounts of chromosomes or DNA copy number aberrations (CNAs) in their genomes.

16 Aug 2016

Scientists create stable boron carrier for targeted radiation-based tumour therapies

Targeted radiation-based therapies for treating cancerous tumours such as 'boron neutron capture therapy' (BNCT), rely on the efficient and effective delivery of the capture agent (in this case, boron) to the tumour.

11 Aug 2016

Diabetes mellitis coexisting with solid-organ malignancies linked to hospitalization risks

Future Science Group today announced the publication of a new article in Future Science OA examining the effects of diabetes on hospitalization risk, chances of multiple admissions, and length of hospitalization stay, for patients suffering from solid-organ malignancies such as breast, colorectal, lung and pancreas, among others.

10 Aug 2016

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

One of the many reasons tumors are so difficult to treat is that they are able to adapt whenever they are exposed to unfavorable conditions.

9 Aug 2016

Oncolytic virotherapy medicine shows positive treatment outcomes in late-stage cancer patients

The surprisingly positive treatment outcomes using Rigvir virotherapy for late stages cancer patients were recently published.

8 Aug 2016

Studies show insurance status may impact patients' health outcomes following cancer diagnosis

Two new studies indicate that health insurance status may impact patients' health outcomes following a diagnosis of cancer.

8 Aug 2016

Physicists receive three-year NSF grant to apply principles of soft-matter physics to cancer therapy

Three physicists in the College of Arts and Sciences are using a major grant to study the dynamics and interactions of cancer cells.

5 Aug 2016

Experimental immunotherapeutic strategy may pave way for new treatments against lymphoma

Lymphoma is a cancer that affects lymphocytes, a type of white blood cell. The disease originates in a lymphoid organ (lymph node, spleen, or bone marrow) before spreading through the blood to infiltrate not only other lymphoid organs but also other tissues.

4 Aug 2016

Malignant News and Research

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Researchers find new way for early prediction of leukemic relapse

Gene fusions in esophageal adenocarcinomas offer new molecular insights into lethal cancer

Stem cells contribute to origin of cancer in different organs of mice

Advances in brain research since patient HM: an interview with Dr Jacopo Annese

Three like-minded nonprofits collaborate to launch immunotherapy clinical trial for pediatric brain tumors

Study shows lymph node stage may have clinical importance among NSCLC patients with M1a disease

New MRI method detects low zinc levels to help identify healthy prostate tissue from cancer

Fruit fly models may help scientists understand underlying mechanism of HPV-induced cancer

New research reveals vanity could play crucial role in protecting young women from harmful UV light

Research findings open avenues for creating new classes of anticancer drugs

Young adult women support stricter regulations, but against total ban of indoor tanning

New study uncovers how chromosomal changes impact tumor formation and growth

Scientists create stable boron carrier for targeted radiation-based tumour therapies

Diabetes mellitis coexisting with solid-organ malignancies linked to hospitalization risks

Wistar scientists discover novel mechanism that helps tumors adapt to hypoxia

Oncolytic virotherapy medicine shows positive treatment outcomes in late-stage cancer patients

Studies show insurance status may impact patients' health outcomes following cancer diagnosis

Physicists receive three-year NSF grant to apply principles of soft-matter physics to cancer therapy

Experimental immunotherapeutic strategy may pave way for new treatments against lymphoma

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