Mass Spectrometry News and Research

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Mass spectrometry is an analytical method used to identify different compounds based on the atomic sample constitution of the molecules and their charge state, which enables “blind” analysis of an unknown sample without any prior knowledge of its composition.

Proteomic mass spectrometry helps identify viruses

Scientists have used mass spectrometry for decades to determine the chemical composition of samples but rarely has it been used to identify viruses, and never in complex environmental samples.

13 Apr 2006

Simple screening process opens door to treating rare metabolic diseases such as Tay-Sachs, Fabry and Gaucher syndromes

Rare metabolic diseases such as Tay-Sachs, Fabry and Gaucher syndromes are caused by enzyme deficiencies and typically have crippling, even fatal, consequences starting at very early ages.

13 Apr 2006

Mass spectrometry could aid biodefense in rapidly detecting dangerous pathogens

Scientists have used mass spectrometry for decades to determine the chemical composition of samples but rarely has it been used to identify viruses, and never in complex environmental samples.

10 Apr 2006

Proteomics yields new drug targets for treating cardiogenic shock

When it comes to cell signaling and bioregulation, it's tough to find a more important molecule than nitric oxide (NO). Dysfunction of NO-mediated signaling is thought to be a culprit in lethal cardiovascular conditions such as angina, and septic, cardiogenic and hemorrhagic shock; it may play a role in many other illnesses as well.

3 Apr 2006

New technology - desorption electrospray ionization detects the boundaries of cancerous tumors

Researchers at Purdue University have shown how a new ultra-fast chemical-analysis tool has numerous promising uses for detecting everything from cancer in the liver to explosives residues on luggage and "biomarkers" in urine that provide an early warning for diseases.

21 Mar 2006

Salmonella research provides clues to antibiotic development

Pathogens are becoming increasingly resistant to antibiotics, causing problems for therapy. Doctors need to have antibiotics available that work in new kinds of ways.

19 Mar 2006

Injection of EU funds for a microdose project

A new EU-funded project kicked off this month which aims to bridge the gap between the laboratory and the clinic. The EU Microdose AMS Partnership Programme (EUMAPP) aims to boost Europe’s expertise in micodosing and its application of AMS, or accelerator mass spectrometry, to developing new candidate drugs for treating diseases the world over.

23 Jan 2006

First genome-wide screen for protein complexes is completed

Researchers in Germany have finished the first complete analysis of the "molecular machines" in one of biology's most important model organisms: S. cerevisiae (baker's yeast). The study from the biotechnology company Cellzome, in collaboration with the European Molecular Biology Laboratory (EMBL), appears in this week's online edition of Nature.

23 Jan 2006

Accurate and rapid method of diagnosing bacterial meningitis

Several hundred serious cases of bacterial meningitis are diagnosed in Australians every year. Bacterial meningitis is a medical emergency that requires immediate diagnosis and treatment, however doctors have always faced difficulty in diagnosis, both in children and adults.

21 Nov 2005

Leeches, useful tools in the treatment of cardiovascular diseases

The leech has recently confirmed its biomedical interest for scientists by showing that it contains an extensive list of new potential molecules that may become useful tools in the treatment of cardiovascular diseases.

24 Oct 2005

New technique could provide a long jump forward in spotting athletes' use of banned substances

A new technique could provide a long jump forward in spotting athletes' use of banned substances, according to research published today in the journal Rapid Communications in Mass Spectrometry.

13 Oct 2005

New role for the blood protein serum amyloid P in the body's response to medical materials

Using a technique called proteomics, the researchers identified many of the blood proteins that stick (adsorb) to the surfaces of medical devices. Blood proteins that adsorb to the surfaces of materials unfold and can be recognized by the body, which then mounts a response against the device.

5 Oct 2005

Tools for studying the chemistry of the brain, neuron by neuron

The human brain is composed of billions of cells, each a separate entity that communicates with others. The chemical interaction of those cells determines personality, controls behavior and encodes memory; but much remains to be understood.

1 Sep 2005

Australian National University facility to help reveal secrets of life

High technology that will enhance the ability of biologists to conduct cutting-edge research has been opened at the Research School of Biological Sciences (RSBS) at the Australian National University.

30 Aug 2005

Excessive alcohol consumption increases risk of certain cancers

Researchers at the National Institute of Standards and Technology (NIST) have developed a new chemical analysis method that has assisted researchers at the National Institute of Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, in demonstrating a potentially important chemical link between alcohol consumption and cancer.

11 Aug 2005

New insight into how protein E75 may control circadian rhythms and metabolic processes

University of Toronto researchers have gained new insight into how a specific protein may control circadian rhythms and metabolic processes, which has implications for treating cholesterol-related diseases.

28 Jul 2005

Forensic use of tandem mass-spectroscopy detects links between banknotes and drugs

Research published in this month’s edition of the journal Rapid Communications in Mass Spectrometry, describes a method that can detect a pattern of contamination on banknotes from drug related crime that is different from the pattern seen in general circulation. The process is significantly faster than other previous methods.

28 Jun 2005

Diagnostic test for Lou Gehrig's disease

Bowser is director of the ALS Tissue Bank and an Associate Professor of Pathology at the University of Pittsburgh School of Medicine who is using a key piece of biomarker discovery equipment known as SELDI to find new ways to identify and eventually treat Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease.

1 Jun 2005

Researchers identify new areas of gene regulation

Researcher Kangling Zhang at the University of California, Riverside is part of a team that has discovered a new way that yeast governs genetic expression and repression, a finding that could be repeated in cells of other organisms.

8 May 2005

Researchers develop new method for facile identification of proteins in bacterial cells

Researchers at the Johns Hopkins Bloomberg School of Public Health have developed a new method for identifying specific proteins in whole cell extracts of microorganisms using traditional peptide mass fingerprinting (PMF).

4 May 2005