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Study shows how chronic psychological stress leads to sickle cell crises

A new study shows how chronic psychological stress leads to painful vessel-clogging episodes--the most common complication of sickle-cell disease (SCD) and a frequent cause of hospitalizations.

30 Jul 2020

Study reveals multiple characteristics of HIV-1-producing cells in vivo

For eradication of HIV-1 infection, it is important to elucidate the detailed features and heterogeneity of HIV-1-infected cells in vivo.

29 Jul 2020

Study identifies phosphorylation-based biomarkers to guide cancer therapy

Precision medicine in cancer treatment uses genetic changes in the cancer cells to select the best therapies for individual patients.

28 Jul 2020

Researchers identify a miRNA that could promote hair regeneration

Researchers from North Carolina State University have identified a microRNA (miRNA) that could promote hair regeneration.

27 Jul 2020

Study reveals molecular cause underlying rare genetic disorder

Virginia Tech scientists have revealed how a nonfunctioning version of an ordinary gene impairs brain structure and function. The findings help explain a genetic form of microcephaly -- a condition where babies' heads are small and grow more slowly than their peers.

27 Jul 2020

Boehringer Ingelheim and Biognosys join forces on applying quantitative proteomics tools in drug discovery

Biognosys announced today that it started working together with Boehringer Ingelheim.

From Biognosys 24 Jul 2020

Epigenomic modifications play key role in the development of lung tumors

As cancer cells evolve, many of their genes become overactive while others are turned down. These genetic changes can help tumors grow out of control and become more aggressive, adapt to changing conditions, and eventually lead the tumor to metastasize and spread elsewhere in the body.

23 Jul 2020

Mouse orthotopic model was used to determine personalized therapy for relapse sarcoma

A team from IDIBELL and ICO, using a mouse orthotopic model, conducted a real-time personalized oncology study to test the best therapeutic option to treat a type of relapse sarcoma. Malignant Peripheral Nerve Sheath Tumor are very aggressive and do not usually have a good prognosis, especially if complete surgical excision cannot be achieved.

23 Jul 2020

Mouse model of pancreatic cancer recreates two subtypes of human disease

Scientists at Cold Spring Harbor Laboratory (CSHL) have created the first mouse model of pancreatic cancer that recreates two subtypes of the human disease.

23 Jul 2020

siRNA-based treatment can reduce psoriasis symptoms

Psoriasis, a chronic skin condition that causes itchy, red, scaly patches, afflicts more than 8 million Americans and 125 million people worldwide.

23 Jul 2020

Amyloid plaques may act as trigger for Alzheimer's disease

The brains of people living with Alzheimer's are riddled with plaques: protein aggregates consisting mainly of amyloid-beta.

23 Jul 2020

Study suggests new ways to fight aggressive brain cancer

A mouse model of glioblastoma, an aggressive type of cancer that can occur in the brain, suggests that this recalcitrant cancer originates from a pool of stem cells that can be a significant distance away from the resulting tumors.

22 Jul 2020

Researchers identify potential new combination therapy to treat head and neck cancer

Researchers at the UCLA Jonsson Comprehensive Cancer Center and UCLA School of Dentistry have identified a potential new combination therapy to treat advanced head and neck squamous cell carcinoma, the most common type of head and neck cancer.

21 Jul 2020

Mouse model of fatal COVID-19 developed for vaccine and drug testing

Now, a new study published on the preprint server bioRxiv in July 2020 presents an engineered transgenic mouse that reproduces the functional and clinical characteristics of severe human SARS-CoV-2 infection.

21 Jul 2020

Research suggests a possible new approach to treating neurodegenerative diseases

Researchers at Vanderbilt University Medical Center have shown for the first time that when one optic nerve in the eye is damaged, as in glaucoma, the opposite optic nerve comes to the rescue by sharing its metabolic energy.

21 Jul 2020

Study may lead to new diagnostic and treatment strategies for fighting bone cancer

Osteosarcoma (OS) is the most common form of aggressive bone cancer. A MedUni Vienna study, led by geneticist Erwin Wagner, has uncovered new insights into the disease mechanisms of OS, paving the way for potential new diagnostic and treatment strategies for fighting the bone disease

21 Jul 2020

A new strategy to combat treatment resistance in choroidal neovascularization

An international team of researchers led by Baylor College of Medicine and Houston Methodist has discovered a strategy that can potentially address a major challenge to the current treatment for choroidal neovascularization (CNV), an aggressive form of age-related macular degeneration, the leading cause of irreversible blindness in the elderly.

16 Jul 2020

RNA editing may repair the underlying cause of Rett Syndrome in mouse model

A genomic error that causes Rett Syndrome, a serious lifelong neurological disorder, can be corrected in the brains of mice by rewriting the genetic instructions carried by the RNA.

15 Jul 2020

Study identifies brain circuitry that plays key role in ASD-relevant behaviors

A team led by UT Southwestern researchers has identified brain circuitry that plays a key role in the dysfunctional social, repetitive, and inflexible behavioral differences that characterize autism spectrum disorders (ASD).

15 Jul 2020

Biological anti-tumor mechanism can provide long-term immune response against tumors

Blocking a newly identified "immune memory checkpoint" in immune cells could improve immunotherapy and help prevent cancers from recurring, according to new findings in mice and human samples by researchers at the UPMC Hillman Cancer Center and the University of Pittsburgh School of Medicine.

15 Jul 2020