Bone Marrow News and Research

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Bone Marrow is the soft, sponge-like tissue in the center of most bones. It produces white blood cells, red blood cells, and platelets.

Study finds cord blood transplant recipients appear to have better outcomes against leukemia

Umbilical cord blood transplants may have advantages beyond offering an alternative stem cell source for leukemia patients without a traditional donor match, according to a study published today in The New England Journal of Medicine.

8 Sep 2016

New study details design and validation of accurate screening test for detecting deadly HAIs

A new study by the Translational Genomics Research Institute details the design and validation of a low-cost, rapid and highly accurate screening tool -- known as KlebSeq -- for potentially deadly healthcare-acquired infections (HAIs), such as Klebsiella pneumoniae.

2 Sep 2016

Blood cancer treatment linked to distinct increase in molecular age of immune cells

Certain cancer treatments are known to take a toll on patients, causing side effects like fatigue, nausea and hair loss. Now, scientists are investigating whether some treatments can cause another long-term side effect: premature aging of important disease-fighting cells.

1 Sep 2016

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

In a study focusing on the role of self-donated (autologous) bone marrow-derived endothelial progenitor cells (EPCs) in placental vascular development, researchers in Japan have discovered that when transplanted into pregnant mice, EPCs can contribute to better blood vessel growth that helps in forming "normalized" placental vascularization, leading, in turn, to reduced recurrent miscarriages by providing a healthier fetal environment during gestation.

30 Aug 2016

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

The Sarcoma research group of Bellvitge Biomedical Research Institute, led by Dr. Òscar Martínez-Tirado, has developed a modified version of an orthotopic model that allows researchers to recreate more closely the metastatic steps in Ewing sarcoma (ES), the second most common bone tumor in children and adolescents.

30 Aug 2016

Large cardiopoietic regenerative therapy trial for patients with congestive heart failure reveals new insights

A therapy that uses bone-marrow stem cells to promote heart repair did not significantly improve the primary outcome over a sham procedure among patients with congestive heart failure.

29 Aug 2016

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Janssen-Cilag International NV has announced the submission of a Type II variation application to the European Medicines Agency (EMA), seeking to broaden the existing marketing authorisation for the immunotherapy DARZALEX® (daratumumab) to include treatment of adult patients with relapsed multiple myeloma who have received at least one prior therapy. The expanded indication is based on daratumumab in combination with lenalidomide (an immmunomodulatory agent) and dexamethasone, or bortezomib (a PI) and dexamethasone.

29 Aug 2016

Researchers find new way for early prediction of leukemic relapse

Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

26 Aug 2016

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Researchers at Newcastle University have been able to accurately predict how children whose cancer returns after treatment for leukaemia are likely to respond to further treatment.

26 Aug 2016

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

A study shows that stimulating the production of interleukin-17A (IL-17A), one of the cytokines released by cells of the immune system, can be an effective strategy for the treatment of visceral leishmaniasis, considered one of the six most important parasitic diseases affecting humans.

25 Aug 2016

Protein complex could play key role in natural development of stem cells into healthy blood cells

A group of proteins best known for helping to activate all mammalian genes has been found to play a particularly commanding role in the natural development of specialized stem cells into healthy blood cells, a process known as hematopoiesis.

25 Aug 2016

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

New research has shown how a cell surface molecule, Lymphotoxin β receptor, controls entry of T-cells into the thymus; and as such presents an opportunity to understanding why cancer patients who undergo bone-marrow transplant are slow to recover their immune system.

25 Aug 2016

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

By assigning a barcode to stem cells, researchers at Lund University in Sweden have made it possible to monitor large blood cell populations as well as individual blood cells, and study the changes over time.

24 Aug 2016

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

Dyskeratosis congenita, or DC, is a rare, inherited disease for which there are limited treatment options and no cure.

18 Aug 2016

New test holds potential to revolutionise diagnosis of childhood leukaemia

Researchers at The University of Manchester have unlocked the potential of a new test which could revolutionise the way doctors diagnose and monitor a common childhood leukaemia.

17 Aug 2016

MSU scientists show how special genes stay open to fight against infections

A new discovery at Michigan State University has revealed how special genes stay open for business, helping diagram a mechanism that plays a key role in fighting inflammation and infections.

17 Aug 2016

Stem cells derived from bone marrow provide better quality of life to transplant patients

A large, nationwide study published in the journal JAMA Oncology found that people who received transplants of cells collected from a donor's bone marrow the original source for blood stem cell transplants, developed decades ago had better self-reported psychological well-being, experienced fewer symptoms of a common post-transplant side effect called graft-vs.-host disease and were more likely to be back at work five years after transplantation than those whose transplanted cells were taken from the donor's bloodstream.

17 Aug 2016

German scientists develop new approach to prevent GvHD after bone marrow transplants

Scientists in Germany have developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants.

16 Aug 2016

Intestinal flora likely to have effect on person's response to drugs

Intestinal flora has multiple influences on human health, but researchers have revealed that it is also likely to have an effect on the body's response to drugs.

12 Aug 2016

ICR researchers identify how genetic variant linked to leukaemia helps cancer cells survive

Scientists at The Institute of Cancer Research, London, have identified how an inherited genetic variant, associated with an increased risk of developing the most common type of leukaemia, helps cancer cells survive. The findings could lead to new ways to target the disease.

12 Aug 2016

Bone Marrow News and Research

Further Reading

Study finds cord blood transplant recipients appear to have better outcomes against leukemia

New study details design and validation of accurate screening test for detecting deadly HAIs

Blood cancer treatment linked to distinct increase in molecular age of immune cells

Study suggests autologous EPC transfusion may prevent miscarriage in high-risk pregnancies

New orthotopic model recapitulates more closely metastatic steps in Ewing sarcoma

Large cardiopoietic regenerative therapy trial for patients with congestive heart failure reveals new insights

Janssen seeks to extend DARZALEX license to benefit more multiple myeloma patients

Researchers find new way for early prediction of leukemic relapse

Breakthrough in cancer cell screening advances personalised treatment of childhood leukaemia

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

Protein complex could play key role in natural development of stem cells into healthy blood cells

Researchers discover novel pathway for immune recovery following bone-marrow transplantation

Assigning barcode to stem cells makes it possible to monitor large blood cell populations

Penn researchers uncover strategy to reverse effects of dyskeratosis congenita

New test holds potential to revolutionise diagnosis of childhood leukaemia

MSU scientists show how special genes stay open to fight against infections

Stem cells derived from bone marrow provide better quality of life to transplant patients

German scientists develop new approach to prevent GvHD after bone marrow transplants

Intestinal flora likely to have effect on person's response to drugs

ICR researchers identify how genetic variant linked to leukaemia helps cancer cells survive

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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