High Throughput News and Research

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High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

In attempt to identify biological markers, or biomarkers, that can signal the presence of cancer and help oncologists determine the best course of therapy when cancer is present, teams of investigators are scouring stored tissue samples obtained from thousands of cancer patients.

4 Dec 2006

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Whether the goal is to separate different types of cells or molecules, methods that rely on the age-old principle of magnetism are a staple among researchers.

20 Nov 2006

Watching a tumor cell migrate

Using a microfluidics device designed to reproduce the physical microenvironment of small blood vessels and the spaces between cells, researchers at the National University of Singapore have imaged single tumor cells deforming as they migrate through the device.

20 Nov 2006

Brookhaven target compounds to fight SARS

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have set the stage for the rapid identification of compounds to fight against severe acquired respiratory syndrome (SARS), the atypical pneumonia responsible for about 800 deaths worldwide since first recognized in late 2002.

20 Nov 2006

Yeast model system may provide a means for treating the earliest stage of Alzheimer's

A century ago this month, German psychiatrist Alois Alzheimer formally described characteristics of the neurodegenerative disease which ultimately came to bear his name. While international efforts to learn about Alzheimer's disease and develop treatments have progressed significantly in recent years, a cure remains an elusive goal.

19 Nov 2006

Brookhaven target new anti-SARS virus drugs

Scientists at Brookhaven National Laboratory have set the stage for the rapid identification of compounds to fight against severe acquired respiratory syndrome (SARS), the atypical pneumonia responsible for about 800 deaths worldwide since first recognized in late 2002.

14 Nov 2006

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Cancer biologists are always on the lookout for new methods of studying the effects that drug therapy has on malignant cells.

6 Nov 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

NIH to map genomic changes of lung, brain, and ovarian cancers

It is estimated that 174,470 new cases of lung cancer will be diagnosed in the United States in 2006. Lung cancer is the major cause of cancer-related mortality in both men and women, with an estimated 162,460 deaths expected to occur in 2006.

13 Sep 2006

NIH launches "Knockout Mouse Project"

The National Institutes of Health (NIH) today awarded a set of cooperative agreements, totaling up to $52 million over five years, to launch the Knockout Mouse Project.

7 Sep 2006

New microfluidic device suitable for large-scale screening of disease-related biomarkers

Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a disposable microchip that replaces space-consuming instrumentation with fast, cost-effective, lab-on-a-chip technology.

5 Sep 2006

Federally approved human embryonic stems inferior to those donated for research

Neural stem cells grown from one of the federally approved human embryonic stem cell lines proved to be inferior to neural stem cells derived from fetal tissue donated for research, a UCLA study has found.

4 Aug 2006

Molecular switch that regulates fat and cholesterol production identified

Researchers at Harvard Medical School and Massachusetts General Hospital have identified how a molecular switch regulates fat and cholesterol production

2 Aug 2006

SRU Biosystems OK'd to conduct business

SRU Biosystems announces the United States District Court for the District of Delaware has resolved in SRU's favor a dispute over the content and scope of a permanent injunction order sought by Corning.

2 Aug 2006

Link between cell's energy use and genome health discovered

While studying how a cell keeps its genetic material intact, scientists at Johns Hopkins got busy alternately knocking out two catalysts vital to managing a yeast cell's energy.

21 Jul 2006

Latest sequencing targets for NHGRI

The National Human Genome Research Institute (NHGRI) has announced several new sequencing targets including the Northern white-cheeked gibbon (Nomascus leucogenys).

19 Jul 2006

SRU Biosystems awarded new U.S. patent

SRU Biosystems has announced that U.S. Patent 7,070,987 (the '987 patent), entitled "Guided mode resonant filter biosensor using a linear grating surface structure" was issued to SRU Biosystems, Inc. on July 4, 2006.

10 Jul 2006

Search for gene search for sporadic amyotrophic lateral sclerosis

Though it's the more common form of the disease, sporadic Amyotrophic Lateral Sclerosis (ALS), which affects roughly 90 percent of those living with the fatal neurodegenerative illness, has been the one less studied, simply because, unlike familial ALS, no genes have turned up.

17 May 2006

New technique to speed discovery of drug targets in chemical genetics

Researchers at Fox Chase Cancer Center have developed a new technique to speed discovery of drug targets in chemical genetics. Fox Chase researcher Jeffrey R. Peterson, Ph.D., and his colleagues describe a new way to swiftly find the proteins targeted by small molecule inhibitors during high-throughput screening (HTS) experiments. The new work offers a critical solution to a common stumbling block in this booming field of drug discovery.

26 Apr 2006

217 new targets for anti-cancer drugs

By identifying novel genes critical to cancer progression, biologists at the U.S. Department of Energy's Argonne National Laboratory have expanded the number of drug targets researchers have available for study to find ways to stop tumors in their tracks.

18 Apr 2006