Mouse Model News and Research

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Gene editing approach removes oral herpes

Infectious disease researchers at Fred Hutchinson Cancer Research Center have used a gene editing approach to remove latent herpes simplex virus 1, or HSV-1, also known as oral herpes.

18 Aug 2020

Researchers identify new therapeutic target for Alzheimer's disease

Scientists at St. Jude Children's Research Hospital are advancing understanding of a potential Alzheimer's disease treatment.

18 Aug 2020

New treatment approach strengthens motor function and muscle of aged mice

In an aging society, one of the most important and urgent tasks of scientific research is to counteract the decline in motor function and muscle weakness that accompanies the aging process.

17 Aug 2020

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

NIBIB-funded researchers have created nanoparticles for successful gene therapy of a mouse model of macular degeneration.

15 Aug 2020

Study identifies new set of multi-tasking taste cells

Our mouths may be home to a newly discovered set of multi-tasking taste cells that - unlike most known taste cells, which detect individual tastes - are capable of detecting sour, sweet, bitter and umami stimuli.

13 Aug 2020

New cell injection technique could help reverse forms of vision loss

University of Toronto Engineering researchers have developed a new method of injecting healthy cells into damaged eyes.

13 Aug 2020

Study sheds new light on mechanisms of cohesin function involved in cancer and cardiac development

Ana Losada, from the Spanish National Cancer Research Centre (CNIO), is the scientist who identified cohesin in vertebrates, a protein that is essential in cell division.

12 Aug 2020

Research looks at convalescent plasma use in COVID-19 mouse model

A new study by researchers at the University of Iowa and published on the preprint server bioRxiv in August 2020 reports the utility of a mouse model that recapitulates several aspects of human COVID-19 and can reflect the antiviral efficacy of new drugs as well.

12 Aug 2020

Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Immunotherapy has revolutionized cancer treatment by stimulating the patient's own immune system to attack cancer cells, yielding remarkably quick and complete remission in some cases. But such drugs work for less than a quarter of patients because tumors are notoriously adept at evading immune assault.

11 Aug 2020

Study may help develop treatment for age-related pulmonary fibrosis

Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that is associated with certain mutations or advanced age.

11 Aug 2020

Gene therapy to the inner retina prevents blindness in mouse model of CLN3 Batten disease

Gene therapy to the inner retina prevented blindness in a mouse model of the neuro-degenerative disorder CLN3 Batten disease.

10 Aug 2020

USF Health researchers develop new reporter mouse strain for identifying P2X2-expressing cells

Despite frequent news announcing "medical breakthroughs," advancements in biomedical and clinical science typically happen incrementally.

7 Aug 2020

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

A new alpha-radioimmunotherapy, 212Pb-anti-CD38, has proven effective in preventing tumor growth and increasing survival in multiple myeloma tumor-bearing mice, according to new research published in the July issue of the Journal of Nuclear Medicine. Given the long half-life, central production and worldwide distribution of 212Pb-anti-CD38, researchers have determined that the α-radioimmunotherapy is not only effective but also clinically feasible as a multiple myeloma treatment.

6 Aug 2020

Scientists create new mouse model of permanent neonatal diabetes

Diabetes seldom occurs in newborns--a condition known as neonatal diabetes. But when it does, it's mostly due to a mutation in a single gene such as the KCNJ11 or insulin (INS).

6 Aug 2020

Eosinophils contribute to antiviral host defense mechanisms during influenza

Eosinophils residing in the airways of mice respond to influenza A virus infection through alterations in surface expression of various markers necessary for migration and cellular immunity responses, according to research published in the Journal of Leukocyte Biology by researchers from Le Bonheur Children's Hospital and the University of Tennessee Health Science Center.

5 Aug 2020

Mouse Model News and Research

Gene editing approach removes oral herpes

Researchers identify new therapeutic target for Alzheimer's disease

New treatment approach strengthens motor function and muscle of aged mice

Nanoparticle carriers expand the effectiveness of gene therapies for human eye diseases

Study identifies new set of multi-tasking taste cells

New cell injection technique could help reverse forms of vision loss

Study sheds new light on mechanisms of cohesin function involved in cancer and cardiac development

Research looks at convalescent plasma use in COVID-19 mouse model

Mouse study shows potential new way to unlock the power of immunotherapy for cancer patients

Study may help develop treatment for age-related pulmonary fibrosis

Gene therapy to the inner retina prevents blindness in mouse model of CLN3 Batten disease

USF Health researchers develop new reporter mouse strain for identifying P2X2-expressing cells

New alpha-radioimmunotherapy for multiple myeloma shows promise in preclinical study

Scientists create new mouse model of permanent neonatal diabetes

Eosinophils contribute to antiviral host defense mechanisms during influenza

GADL1 enzyme may be linked to athletic performances, shows study

Scientists develop new models to study molecular characteristics of lung and pancreatic cancers

Drug candidate successfully reversed memory loss in mouse model of Alzheimer's disease

De novo protein decoys that block SARS-CoV-2

New computational model can help determine drug viability

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