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Researchers using internet to find study participants may hamper recruitment of minority, poor people

Recruiting minorities and poor people to participate in medical research always has been challenging, and that may not change as researchers turn to the internet to find study participants and engage with them online, new research suggests.

29 Jul 2016

Study clarifies role of KLF12 in CRC tumor growth

Results of preclinical studies by MUSC investigators reported in the July 2016 issue of PLOS One, demonstrate for the first time that the transcription factor KLF12 promotes CRC cell growth, in part, by activating EGR1. Furthermore, data demonstrate that KLF12 and EGR1 levels synergistically correlate with poor CRC prognoses.

29 Jul 2016

Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Investigators at Brigham and Women's Hospital have developed a hydrogel patch that can adhere to tumors in a preclinical model of colon cancer, delivering a local, combination treatment as the elastic gel breaks down over time.

29 Jul 2016

Study verifies human gene therapy in MPS I animal model

Researchers are closer to finding a better way to treat children with a rare metabolic disorder called MPS I. It is caused by a deficiency of the key enzyme IDUA needed to break down complex sugars in cells.

29 Jul 2016

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Scientists have developed a new method of measuring the activity of disease-causing mutations in the LRRK2 gene, a major cause of inherited Parkinson's disease.

29 Jul 2016

Study identifies two proteins crucial for self-renewal of skin stem cells

Our skin renews, heals wounds, and regenerates the hair that covers it thanks to a small group of stem cells. These cells continually produce new ones, which appear on the skin surface after a few days.

29 Jul 2016

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.

29 Jul 2016

Scientists identify novel way to target lung cancer through KRAS gene

UT Southwestern Medical Center researchers have identified a new way to target lung cancer through the KRAS gene, one of the most commonly mutated genes in human cancer and one researchers have so far had difficulty targeting successfully.

29 Jul 2016

New study to examine genomics of anti-platelet therapy after coronary interventions

Which antiplatelet medication is best after a coronary stent? The Tailored Antiplatelet Therapy to Lessen Outcomes After Percutaneous Coronary Intervention (TAILOR-PCI) Study examines whether prescribing heart medication based on a patient's CYP2C19 genotype will help prevent heart attack, stroke, unstable angina, and cardiovascular death in patients who undergo percutaneous coronary intervention (PCI), commonly called angioplasty.

29 Jul 2016

Blood pressure hormone system important for cardiovascular health can promote obesity

New research by University of Iowa scientists helps explain how a hormone system often targeted to treat cardiovascular disease can also lower metabolism and promote obesity.

29 Jul 2016

Scientists identify new group of molecules that could slow tumour growth in prostate cancer patients

Prostate cancer patients have been offered hope after scientists at Newcastle University, UK, have identified a new group of molecules that could be targeted to slow tumour growth.

28 Jul 2016

Human immune system proteins can help combat chlamydia infections

Scientists from Federal Research and Clinical Centre of Physical-Chemical Medicine, Koltzov Institute of Developmental Biology and MIPT have shown that peptidoglycan recognition proteins (PGLYRPs) of the human immune system can play a key role in the fight against chlamydia infections. Their study was published in Infection and Immunity.

28 Jul 2016

New gene therapy shows promising results for treating neurodegenerative disorders

A new gene therapy approach designed to replace the enzyme that is deficient in patients with the inherited neurodegenerative disorders Tay-Sachs and Sandhoff diseases successfully delivered the therapeutic gene to the brains of treated mice, restored enzyme function, and extended survival by about 2.5-fold.

28 Jul 2016

Genetic News and Research

Researchers using internet to find study participants may hamper recruitment of minority, poor people

Study clarifies role of KLF12 in CRC tumor growth

Triple-combination therapy patch shrinks tumors, prevents recurrence in colon cancer mice model

Study verifies human gene therapy in MPS I animal model

Novel method sheds light on how disruption in LRRK2 gene causes inherited Parkinson's disease

Study identifies two proteins crucial for self-renewal of skin stem cells

Novel conjugate therapy shows promise in destroying ALL cells with few side effects

Scientists identify novel way to target lung cancer through KRAS gene

New study to examine genomics of anti-platelet therapy after coronary interventions

Blood pressure hormone system important for cardiovascular health can promote obesity

Scientists identify new group of molecules that could slow tumour growth in prostate cancer patients

Human immune system proteins can help combat chlamydia infections

New gene therapy shows promising results for treating neurodegenerative disorders

Researchers discover genetic changes in MSH3 gene in patients with hereditary colon cancer

Scientists identify mutation responsible for new, rare genetic disorder

Study finds risk markers for Parkinson's disease hiding in unusual spots

New consensus statement recommends transition of care for adolescents with neurologic disorders

Revolutionary surgery improves airway and jaw position in children with Treacher Collins syndrome

Scientists identify new genetic variations contributing to onset of APL

Researchers find easy way to ensure baby boomers get tested for hepatitis C

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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