Protein C News and Research

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Study gives new insights into how cells leverage GPCRs to control inflammation

G-protein-coupled receptors are everywhere in our bodies. They are embedded in our cell membranes, where they act as signal transducers, allowing cells to respond to their external environments.

19 Sep 2018

Study: CXCL14 protein is secreted by brown adipose tissue and has beneficial effects in metabolic diseases

A scientific team found that the CXCL14 protein, associated with tumor progression and organogenesis, causes beneficial effects to metabolic diseases such as obesity and diabetes.

19 Sep 2018

Researchers acquire new insights into DNA polymerases

Complex biological systems can be described as a network of chemical processes that take place in molecules. The scientists of the "ChemLife" research initiative at the University of Konstanz are working together in an equally active network with dynamic interconnections - both subject-specific and interdisciplinary.

19 Sep 2018

Potential drugs to treat neurodegenerative diseases garner $3 million grant

A new four-year, $3 million grant will enable Scripps Research scientists to advance compounds that may protect neurons in diseases caused by toxic protein accumulation, including Parkinson's, ALS, Alzheimer's and Creutzfeldt-Jakob disease.

18 Sep 2018

Research shows enlarged genotype-phenotype correlation for three-base pair deletion in NF1

International collaborative research led by Ludwine Messiaen, Ph.D., shows that while a three-base pair, in-frame deletion called p.Met992del in the NF1 gene has a mild phenotype for people with the genetic disorder neurofibromatosis type 1, or NF1, the mutation does cause complications.

18 Sep 2018

Researchers use CRISPR screen to reveal new targets in squamous cell carcinomas

A little p63 goes a long way in embryonic development - and flaws in p63 can result in birth defects like cleft palette, fused fingers or even missing limbs.

18 Sep 2018

Microbiota in the intestines and cell stress cause colon cancer

"With our study we originally wanted to study the role of bacteria in the intestines in the development of intestinal inflammation," explains Professor Dirk Haller from the Department of Nutrition and Immunology at the Weihenstephan Science Centre of the TUM.

18 Sep 2018

Study aims to investigate risk factors for PPCs in surgical patients with gastric cancer

As one of the most common malignant tumors, gastric cancer occupies the second leading cause of cancer-related deaths worldwide with an increasing trend.

18 Sep 2018

Researchers find way to map mysterious content of non-coding RNA

Researchers from the University of North Carolina have found a way of categorising long non-coding RNAs (lnc-RNAs) by their probable function.

18 Sep 2018

Purifying Proteins from Mammalian Cell Culture

In many cases mammalian cells are the only option to produce recombinant proteins with correct post-translational modifications, e.g. glycosylation, which are required for proper function of the therapeutic protein.

From Sartorius 18 Sep 2018

Amyloid β protein makes comeback as therapeutic target for Alzheimer's disease

For many years amyloid β protein was considered to be a promising therapeutic target in Alzheimer's disease but, for a long time, research results were very disappointing.

18 Sep 2018

KAIST researchers develop heart-targeting drug delivery technology using tannin acid

Typical methods of drug delivery to the heart require surgical procedures involving incisions in the chest wall and bones.

18 Sep 2018

Researchers use CRISPR to identify gene that helps cells resist flavivirus infection

UT Southwestern researchers today report the first use of CRISPR genome-wide screening to identify a gene that helps cells resist flavivirus infection. That nasty class of pathogens includes West Nile virus, dengue fever, Zika virus, and yellow fever.

18 Sep 2018

New research on sperm quality updates advice for couples trying to conceive

Could doctors at fertility clinics be giving men bad advice? Dr. Da Li and Dr. XiuXia Wang, who are clinician-researchers at the Center for Reproductive Medicine of Shengjing Hospital in Shenyang in northeast China, think so.

17 Sep 2018

New discovery could improve diagnosis and treatment of lupus in black Africans

Two variants of an autoimmune disease that affects thousands but is hard to diagnose are relatively common among black Africans, research shows.

17 Sep 2018

People battling substance use disorders may benefit from meth-relapse prevention compound

New research raises the possibility that a wider group of people battling substance use disorders may benefit from a Scripps Research-developed relapse-prevention compound than previously thought.

17 Sep 2018

Study reveals mechanism underlying plants’ ability to signal defense

Researchers at the University of Wisconsin-Madison have developed fluorescing plants and videoed them to find out how the plants defend against attack.

17 Sep 2018

Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection

The bacteria Pseudomonas aeruginosa can cause serious and difficult to treat infections. The infection process involves the activation of toxic substances from the bacteria by a common protein in our cells.

17 Sep 2018

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

Proteins are essential constituents of cells and their compartments. Prof. Johannes Herrmann, a researcher at the Technische Universität Kaiserslautern, Germany, and his team discovered a novel mechanism by which newly synthesized proteins reach their respective target compartment in the cell.

17 Sep 2018

New studies examine links between fatty liver disease and mitochondrial dysfunction

Researchers at Northeast Ohio Medical University studied the lifespan of mitochondrial proteins in a mouse model of fatty liver disease. Comparing the amount of protein between healthy mice and a mouse model of nonalcoholic fatty liver disease gave them an estimate of each protein's half-life.

17 Sep 2018

Protein C News and Research

Study gives new insights into how cells leverage GPCRs to control inflammation

Study: CXCL14 protein is secreted by brown adipose tissue and has beneficial effects in metabolic diseases

Researchers acquire new insights into DNA polymerases

Potential drugs to treat neurodegenerative diseases garner $3 million grant

Research shows enlarged genotype-phenotype correlation for three-base pair deletion in NF1

Researchers use CRISPR screen to reveal new targets in squamous cell carcinomas

Microbiota in the intestines and cell stress cause colon cancer

Study aims to investigate risk factors for PPCs in surgical patients with gastric cancer

Researchers find way to map mysterious content of non-coding RNA

Purifying Proteins from Mammalian Cell Culture

Amyloid β protein makes comeback as therapeutic target for Alzheimer's disease

KAIST researchers develop heart-targeting drug delivery technology using tannin acid

Researchers use CRISPR to identify gene that helps cells resist flavivirus infection

New research on sperm quality updates advice for couples trying to conceive

New discovery could improve diagnosis and treatment of lupus in black Africans

People battling substance use disorders may benefit from meth-relapse prevention compound

Study reveals mechanism underlying plants’ ability to signal defense

Researchers map 3D structure of toxic proteins used by Pseudomonas aeruginosa to trigger infection

Scientists discover novel mechanism by which synthesized proteins reach target compartment in cell

New studies examine links between fatty liver disease and mitochondrial dysfunction

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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