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Anticancer drug may reduce mortality and speed up recovery for severe COVID-19 patients

Treating severe COVID-19 patients with the anticancer drug bevacizumab may reduce mortality and speed up recovery, according to a small clinical study in Italy and China that was led by researchers at Karolinska Institutet in Sweden between February and April 2020.

6 Feb 2021

Novel immunotherapy approach to revert the main hallmarks of cat allergy

Researchers from the Department of Infection and Immunity of the Luxembourg Institute of Health (LIH) brought forward the potential of high doses of a specific adjuvant molecule, namely CpG oligonucleotide, in successfully modulating the immune system's allergic response to the main cat allergen Fel d 1, thereby inducing a tolerance-promoting reaction and reverting the main hallmarks of cat allergy.

5 Feb 2021

Study uncovers link between T cell-mediated inflammation and cardiac dysfunction

Inflammation is supposed to help protect us - it's part of an immune response to fight off pathogens and clear infections. But patients with cardiac disease often have chronic inflammation that damages their hearts, even with no infection present.

5 Feb 2021

Zinc supplements can improve infertility issues during COVID-19 pandemic

Wayne State University School of Medicine researchers have reported that zinc supplements for men and women attempting to conceive either naturally or through assisted reproduction during the COVID-19 pandemic may prevent mitochondrial damage in young egg and sperm cells, as well as enhance immunity against the virus.

5 Feb 2021

New process separates beneficial glucocorticoids from unwanted side-effects

A collaboration led by Scripps Research has developed a way to separate the beneficial anti-inflammatory properties of a group of steroids called glucocorticoids from some of their unwanted side-effects, through an optimization process they named "ligand class analysis."

3 Feb 2021

Immune profiling shows differences in COVID-19 and influenza pathologic pathways

A study conducted at Johns Hopkins University School of Medicine in Baltimore has revealed distinct differences in the immune pathways that are activated by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and those that are activated by influenza.

2 Feb 2021

Study shows safety and effectiveness of two recommended ICU sedatives

Sedative medications used in intensive care are associated with increased delirium, which is in turn connected with higher medical costs and greater risk of death and ICU-related dementia.

2 Feb 2021

ACE2 agonist C21 relieves respiratory difficulty in COVID-19

A new study describes a pilot study on the efficacy of a molecule called C21, which enhances the activity of the angiotensin-converting enzyme 2 (ACE2), the host cell receptor that facilitates viral entry.

2 Feb 2021

Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Over the past months, many potential antivirals against SARS-CoV-2 have been identified as deserving further development to target several viral proteins. A new study deals with one such molecule, the viral main protease (Mpro) inhibitor GC-376, and describes its efficacy in inhibiting virus-host interaction.

2 Feb 2021

Study uncovers new anti-inflammatory role for blood clot protein fibrinogen

Flinders University researchers have discovered a new anti-inflammatory role for well-known blood clot protein fibrinogen, which could support targeted new treatments for kidney, heart and other common diseases.

1 Feb 2021

Can metformin reduce mortality in diabetic individuals with severe COVID-19?

A new study by researchers in China and the U.S. describes a round-up of the effects of commonly used hypoglycemic drugs on the outcomes of COVID-19 in diabetic patients.

1 Feb 2021

Ivermectin may not be the ‘silver bullet’ antiviral against COVID-19

A team of researchers based in Peru and the U.S. recently examined the role of the anti-parasitic drug ivermectin in treating COVID-19.

1 Feb 2021

Colchicine may have therapeutic potential against COVID-19

A new study describes the results of colchicine in mitigating the inflammatory storm associated with COVID-19, and thus preventing a percentage of severe and critical cases.

1 Feb 2021

Synergistic effect between NF-κB inhibitors and zinc in vitro reducing ACE2 expression

Researchers at National Taiwan University Hospital in Taipei have conducted a study demonstrating the potential effectiveness of a novel drug combination at reducing morbidity and mortality in coronavirus disease 2019 (COVID-19).

31 Jan 2021

DSMB recommends continuation of Phase 2/3 study of opaganib for severe COVID-19

RedHill Biopharma Ltd., a specialty biopharmaceutical company, today announced that the independent Data Safety Monitoring Board (DSMB) for the global Phase 2/3 study of opaganib in patients with severe COVID-19, unanimously recommended to continue the study following a pre-scheduled futility review of unblinded efficacy data from the first 135 patients treated in the study and safety data from the first 175 patients.

30 Jan 2021

Genetically engineered cartilage delivers anti-inflammatory drug in response to knee activity

Working to develop new treatments for osteoarthritis, researchers at Washington University School of Medicine in St. Louis have genetically engineered cartilage to deliver an anti-inflammatory drug in response to activity similar to the bending of a knee or other motions that put stress on joints.

27 Jan 2021

Anakinra shows therapeutic potential in critically ill COVID-19 patients

A team of international scientists recently conducted an open-level clinical trial to investigate the effects of personalized immunotherapy on critically ill COVID-19 patients.

27 Jan 2021

Could spironolactone treat COVID-19-related pneumonia and pulmonary fibrosis?

Researchers have described the potential of the drug spironolactone, a potassium-sparing diuretic, and anti-androgen, in preventing or alleviating the severity of COVID-19 pneumonia, and in preventing pulmonary fibrosis.

27 Jan 2021

Melatonin reduces cysts in the renal tubules of fruit flies

A hormone commonly associated with sleep-wake regulation has been found to reduce cysts in fruit flies, according to Concordia researchers. It's a finding that may affect the way we treat some kidney diseases and reduce the need for kidney transplants.

27 Jan 2021

New compound could lead to a new class of diabetes drugs

Research led by The Ohio State University Wexner Medical Center and College of Medicine identified a new compound that might serve as a basis for developing a new class of drugs for diabetes.

27 Jan 2021