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SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

Unique combination of nanomaterials in DNA biosensor enables easier SARS-CoV-2 detection

A recent paper that was published in the Talanta journal dedicated to original reports in pure and applied analytical chemistry presents for the first time the combination of two different nanomaterials – gold nanomaterials (AuNMs) and CDs for the development of an improved electrochemiluminescence (ECL) DNA biosensor.

10 Jan 2022

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

A team led by University of California, Irvine researchers has developed a new biopsy technology that can profile multiple tumor microenvironment biomarkers simultaneously, revealing cellular spatial organization and interactions that will help advance personalized disease diagnosis and treatment.

10 Jan 2022

Hybrid immunity shown to offer sub-optimal protection against SARS-CoV-2 Omicron variant

In a new study, researchers evaluated the neutralizing power of the vaccine against SARS-CoV-2 and vaccine plus infection-induced antibodies against the Omicron variant in a live virus neutralization assay.

10 Jan 2022

Efficacy of surgical masks and N95 respirators in lowering SARS-CoV-2 transmission

In a new study, researchers determined the adherence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant to masks and respirators and the role of buccal protection in controlling SARS-CoV-2 transmission.

10 Jan 2022

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

In a new study, researchers determined three-dose messenger ribonucleic acid (mRNA) vaccinated kidney transplant recipients’ (KTRs) neutralizing responses against SARS-COV-2 variants, breakthrough coronavirus disease 2019 infection rate, and transplant rejection rate.

10 Jan 2022

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

Researchers posted the results of a retrospective observational cohort study in which they determined the humoral and cellular responses in ISP to primary and booster doses of COVID-19 vaccines.

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Characterizing these engineered sEVs, the researchers demonstrated that the soluble angiotensin-converting enzyme 2 (sACE-2) loaded sEV successfully binds and thus inhibits the entry of wild-type SARS-CoV-2 as well as its variants, protecting against SARS-CoV-2 infection. They also demonstrated the therapeutic efficacy of these engineered sEVs in vivo.

9 Jan 2022

Bolstering current therapeutic antibody treatments to help fight Omicron infections

Researchers test the neutralizing action of a panel of eight therapeutic monoclonal antibodies against the SARS-CoV-2 Omicron (B.1.1.529) variant.

9 Jan 2022

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

Researchers demonstrate that the SARS-CoV-2 Omicron variant grows rapidly in human primary nasal epithelial cultures.

9 Jan 2022

SARS‑CoV‑2 Omicron variant escapes monoclonal antibodies

Researchers determine the neutralizing activity of four mAbs against ten strains of SARS-CoV-2.

9 Jan 2022

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Researchers developed a human A549 lung epithelial cell-based model to probe SARS-CoV-2 replication.

9 Jan 2022

Dual-receptors help widespread dissemination of SARS-CoV-2

Researchers demonstrate the role of integrins in the establishment of the SARS-CoV-2 infection.

9 Jan 2022

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

A new study found that a booster dose vaccination against COVID-19 was successful in taking binding. and neutralizing antibodies to levels higher than those observed after the initial double-dose regimen.

7 Jan 2022

Vaccine breakthrough COVID-19 infections found to be less likely transmitted

A new study displays that vaccine breakthrough COVID-19 infections are far less likely to transmit from the index patient to contacts than infections in partially or unvaccinated individuals.

7 Jan 2022

Reinfection with SARS-CoV-2 in children

These findings bear out earlier reports that COVID-19 is less frequent and severe in children than adults.

7 Jan 2022

Integrating Microplate Evaporators with Liquid Handling Robots

The Ultravap® Mistral family of microplate evaporators from Porvair Sciences are used in labs worldwide to remove the traditional laboratory ‘bottleneck’ of solvent evaporation from 12- to 384-well microplates and vials up to 15cm tall.

From Porvair Sciences Limited 7 Jan 2022

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

A new study aimed to explore whether there is a way to induce the production of potent neutralizing antibodies capable of neutralizing all SARS-CoV-2 variants - including Omicron.

7 Jan 2022

Assay News and Research

SARS-CoV-2 activates microglia in the brain

Unique combination of nanomaterials in DNA biosensor enables easier SARS-CoV-2 detection

Researchers develop new biopsy technology for profiling multiple tumor microenvironment biomarkers

Hybrid immunity shown to offer sub-optimal protection against SARS-CoV-2 Omicron variant

Efficacy of surgical masks and N95 respirators in lowering SARS-CoV-2 transmission

Neutralization of SARS-CoV-2 variants by three-dose mRNA vaccinated kidney transplant recipient sera

Humoral and cellular response to primary and booster COVID-19 vaccination in immunosuppressed patients

SARS-CoV-2 shown to spread through cell-to-cell transmission

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Bolstering current therapeutic antibody treatments to help fight Omicron infections

SARS-CoV-2 Omicron variant uses endosomal entry pathway and grows in upper respiratory tract cells

SARS‑CoV‑2 Omicron variant escapes monoclonal antibodies

Lab engineered human A549 lung cell model conducive for investigating SARS-CoV-2 antivirals

Dual-receptors help widespread dissemination of SARS-CoV-2

Booster mRNA vaccination effective in reviving anti-SARS-CoV-2 antibody titers among the elderly

Vaccine breakthrough COVID-19 infections found to be less likely transmitted

Reinfection with SARS-CoV-2 in children

Integrating Microplate Evaporators with Liquid Handling Robots

Broad cross-neutralization antibodies found to be effective against SARS-CoV-2 Omicron variant

Measuring Drug-Target Residence Times with Biochemical Assays eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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