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New strategy treats fatal autoimmune disease without outward off-target effects

In a study with potentially major implications for the future treatment of autoimmunity and related conditions, scientists from the Perelman School of Medicine at the University of Pennsylvania have found a way to remove the subset of antibody-making cells that cause an autoimmune disease, without harming the rest of the immune system.

4 Jul 2016

Scientists investigate molecular mechanisms that regulate STAT3 activity

Hokkaido University scientists are getting closer to understanding the function of a protein involved in vital cellular processes. This may lead to the discovery of drugs that can treat some cancers and autoimmune disorders.

1 Jul 2016

Study focuses on critical proteins involved in ovarian cancer biology

In what is believed to be the largest study of its kind, scientists at the Pacific Northwest National Laboratory, Johns Hopkins University and their collaborators from institutions across the nation have examined the collections of proteins in the tumors of 169 ovarian cancer patients to identify critical proteins present in their tumors.

30 Jun 2016

Vitamin D sufficiency linked to better pancreatic cancer survival

Survival is improved in pancreatic cancer patients with sufficient versus deficient plasma levels of 25-hydroxyvitamin D, as assessed prior to diagnosis.

28 Jun 2016

Prognostic factor could help identify tumor recurrence after surgery for prostate cancer

Slightly more than 10% of all patients who undergo successful surgery for prostate cancer have an elevated risk of tumor recurrence afterwards - especially as metastases.

27 Jun 2016

Neurofibromatosis causes benign tumor formation in normal nervous tissue

Although neurofibromatosis (NF) is not commonly discussed, it affects more than 2 million people worldwide.

24 Jun 2016

New study finds many healthcare providers underestimate actual radiation dose from CT scans

Computed tomography (CT) scans are an invaluable diagnostic tool in modern medicine, but they do come at a price: exposing patients to potentially dangerous ionizing radiation.

24 Jun 2016

University education linked to higher risk of brain tumor

Men and women with a university degree are more prone to developing a brain tumor than people who do not take up higher education, according to an observational study published in the Journal of Epidemiology & Community Health.

21 Jun 2016

Scientists identify on/off obesity-induced switch to slow cancer progression

Having established that excessive fat tissue can fuel the growth of certain cancers, researchers have turned their attention to the molecular mechanisms involved in the process in the hopes of developing new cancer treatments.

21 Jun 2016

Scientific paper supports concept of CarThera's intracranial ultrasound implant to disrupt blood-brain barrier

CarThera, a French company based at the Brain and Spine Institute, that designs and develops innovative ultrasound-based medical devices to treat brain disorders, today announces the publication in Science Translational Medicine of a scientific paper on initial successes in disrupting the blood-brain barrier (BBB) with the use of ultrasound.

20 Jun 2016

Researchers develop AI-powered systems to make pathologic diagnoses more accurate

Pathologists have been largely diagnosing disease the same way for the past 100 years, by manually reviewing images under a microscope. But new work suggests that computers can help doctors improve accuracy and significantly change the way cancer and other diseases are diagnosed.

20 Jun 2016

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

Researchers from the 'Angiogenesis signaling pathways' research group of the Institute of Biomedical Investigation of Bellvitge, led by Dr. Mariona Graupera, have unveiled the potential therapeutic benefit of a selective inhibitior of the PI3-kinase (PI3K) protein in pancreatic neuroendocrine tumors (PanNETs).

17 Jun 2016

New research paves way for potential notch-based anticancer therapeutics

A recent study led by scientists at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, in collaboration with the Univerity of Maryland School of Pharmacy and StemSynergy Therapeutics, Inc., has identified a small-molecule inhibitor of the Notch pathway, paving the way for a potential new class of personalized cancer medicines.

16 Jun 2016

Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

A newly devised tumor-specific fluorescent agent and imaging system guided surgeons in real time to remove additional tumors in ovarian cancer patients that were not visible without fluorescence or could not be felt during surgery.

15 Jun 2016

Four miRNAs may hold vital clue to disease progression in gliobastoma

Scientists at the Helmholtz Zentrum München and the Ludwig Maximilians University of Munich have developed a new method of predicting disease progression in gliobastoma patients who have undergone standard treatment.

14 Jun 2016

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Non-small cell lung cancers have a collective reputation for not responding very well to chemotherapy. Researchers at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) are presenting a means of evaluating an immunotherapy that fights off NSCLC by strengthening a patient's own immune system.

14 Jun 2016

Molecular imaging technique could help optimize radiotherapy dose to combat NETs

Aggressive neuroendocrine cancer is something of a dark horse--a rare, elusive and persevering force linked to discouraging long-term survival rates.

14 Jun 2016

EPFL researchers reprogram TAMs to prevent tumor metastasis

One of the major obstacles with treating cancer is that tumors can conscript the body's immune cells and make them work for them. Researchers at EPFL have now found a way to reclaim the corrupted immune cells, turn them into signals for the immune system to attack the tumor, and even prevent metastasis.

14 Jun 2016

Genetic blood test can help predict patient’s respone to neuroendocrine cancer therapy

Malignant neuroendocrine tumors (NETs) are relatively rare, notoriously difficult to treat, and associated with poor long-term survival. According to research presented at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, an investigative blood test could predict how patients will respond to peptide receptor radionuclide therapy (PRRT) before they commit to a course of treatment.

14 Jun 2016

Researchers discover AF1q protein linked to multiple myeloma, EMD

A group of researchers from the University of Louisville, Japan and Austria is the first to identify a protein, AF1q, associated with multiple myeloma and a condition that occurs in approximately one-fourth of very aggressive multiple myeloma, extramedullary disease or EMD.

10 Jun 2016

Malignant News and Research

New strategy treats fatal autoimmune disease without outward off-target effects

Scientists investigate molecular mechanisms that regulate STAT3 activity

Study focuses on critical proteins involved in ovarian cancer biology

Vitamin D sufficiency linked to better pancreatic cancer survival

Prognostic factor could help identify tumor recurrence after surgery for prostate cancer

Neurofibromatosis causes benign tumor formation in normal nervous tissue

New study finds many healthcare providers underestimate actual radiation dose from CT scans

University education linked to higher risk of brain tumor

Scientists identify on/off obesity-induced switch to slow cancer progression

Scientific paper supports concept of CarThera's intracranial ultrasound implant to disrupt blood-brain barrier

Researchers develop AI-powered systems to make pathologic diagnoses more accurate

Researchers uncover potential therapeutic benefit of PI3K protein in PanNETs

New research paves way for potential notch-based anticancer therapeutics

Novel imaging technique may assist surgeons to improve visualization of ovarian tumors during surgery

Four miRNAs may hold vital clue to disease progression in gliobastoma

FDG-PET imaging tracks ability of atezolizumab to bolster immunity against NSCLC

Molecular imaging technique could help optimize radiotherapy dose to combat NETs

EPFL researchers reprogram TAMs to prevent tumor metastasis

Genetic blood test can help predict patient’s respone to neuroendocrine cancer therapy

Researchers discover AF1q protein linked to multiple myeloma, EMD

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