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'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

In an expanded, three-year clinical trial of 86 patients with colorectal and 11 other kinds of cancer that have so-called 'mismatch repair' genetic defects, scientists at Johns Hopkins Medicine and its Bloomberg~Kimmel Institute for Cancer Immunotherapy have found that half of the patients respond to an immunotherapy drug called pembrolizumab.

9 Jun 2017

Fake contaminant opioids found in prescription pills leading to fatal overdoses in Georgia

There has been a spate of several overdoses in Georgia this week leading to four deaths according to the officials at Georgia Bureau of Investigation. The Bureau issued a statement saying that there is presence of two synthetic opioids in the fake prescription pills that led to these cases of overdose.

9 Jun 2017

Opana ER – a long acting opioid painkiller, to be pulled from the markets as per FDA directive

The US Food and Drug Administration this Thursday (8th June 2017) directed pharmaceutical company Endo Pharmaceuticals to remove one of its powerful opioid painkillers Opana ER, that provides a long term relief of pain but also poses a risk of drug abuse.

9 Jun 2017

Adult male farmers in Malaysia more likely to contract 'monkey malaria'

Adult male farmers in Malaysia are more than twice as likely to contract Plasmodium knowlesi malaria - an infection usually found only in monkeys - than other people in their communities, according to a new study published in The Lancet Planetary Health.

9 Jun 2017

New cancer drug shows promise to treat leukemia in mouse models

Almost 6,000 new cases of acute lymphoblastic leukemia, or ALL, are expected to be diagnosed this year in the United States. The blood cancer can affect both children and adults.

9 Jun 2017

New research design offers way to assess safety of approved drugs

As the pace of drug approvals accelerates and the U.S. Food and Drug Administration faces potential budget cuts, a new research design from Perelman School of Medicine scientists offers a new way to successfully assess safety of newly approved drugs, as well as drugs that have been on the market for a long time and have had a marked rise in their use.

9 Jun 2017

Scientists find way to recover protein structure after chemical denaturation

Scientists from ITMO University in Saint Petersburg and Hebrew University in Jerusalem have found a way to recover a protein structure after its chemical denaturation.

9 Jun 2017

Removal of senescent cells could delay onset of age-related pathologies

A recent study, led by an international team of researchers confirms that targeted removal of senescent cells (SnCs), accumulated in many vertebrate tissues as we age, contribute significantly in delaying the onset of age-related pathologies.

9 Jun 2017

Researchers define action profile of experimental drug intended to treat chronic pain

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells.

9 Jun 2017

Combination treatment found to effective in patients with tophaceous gout

The drug lesinurad in combination with febuxostat was better at lowering blood levels of urate than febuxostat alone in a phase III clinical trial of 324 patients with tophaceous gout.

9 Jun 2017

Southern Research aims to develop new radiosensitizers that may greatly benefit cancer patients

Two out of three cancer patients are treated with radiation, but the therapy often fails to wipe out the tumor or slow its growth. Southern Research is working to develop a new class of drugs that will help the radiation deliver a more powerful punch to the disease.

9 Jun 2017

UNC researchers identify how class of antiviral drugs interacts with HCV

Globally, an estimated 71 million people are living with chronic hepatitis C virus (HCV). Over decades of infection, chronic HCV infection results in progressive damage to the liver and an increased risk for end stage liver disease and liver cancer, making the virus the leading cause of liver-related deaths in the United States today.

9 Jun 2017

Single chemotherapy treatment can negatively impact gait and balance, study shows

A single chemotherapy treatment can result in a significant negative impact on walking gait and balance, putting patients at an increasing risk for falls, according to a new study involving breast cancer patients conducted by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

9 Jun 2017

Heroin use in the U.S. estimated to cost society more than $51 billion

Heroin use in the United States was estimated to cost society more than $51 billion in 2015, according to new research at the University of Illinois at Chicago.

9 Jun 2017

Novartis announces data revealing efficacy of new monoclonal antibody therapy in preventing migraine

Novartis today announced that it will present 19 scientific abstracts at the 59th Annual Scientific Meeting of the American Headache Society.

8 Jun 2017

Activating bitter taste receptors can stop unwanted contractions that occur during preterm labor

This could be good news for those trying to prevent preterm labor: New research published online in The FASEB Journal suggests that exposing bitter taste receptors in the uterus to certain substances can stop many unwanted contractions that occur during premature labor.

8 Jun 2017

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

It is almost axiomatic in medicine that the study of rare disorders informs the understanding of more common, widespread ailments.

8 Jun 2017

Scientists create 'immunoswitch' particles that slow cancer growth in test animals

Scientists at Johns Hopkins have created a nanoparticle that carries two different antibodies capable of simultaneously switching off cancer cells' defensive properties while switching on a robust anticancer immune response in mice.

8 Jun 2017

New florescent imaging technique tracks actions of key enzymes in cancer, kidney disease

Researchers at the Universities of York and Leiden have pioneered a technique which uses florescent imaging to track the actions of key enzymes in cancer, genetic disorders and kidney disease.

8 Jun 2017

Cannabis use during adolescence linked to greater risk of illegal substance abuse in early adulthood

According to the study published online in the Journal of Epidemiology & Community Health, regular and occasional use of cannabis as an adolescent is linked with a greater risk of other illicit drug consumption in early adulthood. The study by Bristol's Population Health Science Institute also found that cannabis use was connected with harmful drinking and smoking. One in five adolescents are at a risk of tobacco dependency, harmful alcohol consumption, and illicit drug use.

8 Jun 2017

Drugs News and Research

'Mismatch repair' genetic defects drive cancer patient's response to immunotherapy drugs

Fake contaminant opioids found in prescription pills leading to fatal overdoses in Georgia

Opana ER – a long acting opioid painkiller, to be pulled from the markets as per FDA directive

Adult male farmers in Malaysia more likely to contract 'monkey malaria'

New cancer drug shows promise to treat leukemia in mouse models

New research design offers way to assess safety of approved drugs

Scientists find way to recover protein structure after chemical denaturation

Removal of senescent cells could delay onset of age-related pathologies

Researchers define action profile of experimental drug intended to treat chronic pain

Combination treatment found to effective in patients with tophaceous gout

Southern Research aims to develop new radiosensitizers that may greatly benefit cancer patients

UNC researchers identify how class of antiviral drugs interacts with HCV

Single chemotherapy treatment can negatively impact gait and balance, study shows

Heroin use in the U.S. estimated to cost society more than $51 billion

Novartis announces data revealing efficacy of new monoclonal antibody therapy in preventing migraine

Activating bitter taste receptors can stop unwanted contractions that occur during preterm labor

Researchers who study HED identify mechanism that may be disrupted in male pattern baldness

Scientists create 'immunoswitch' particles that slow cancer growth in test animals

New florescent imaging technique tracks actions of key enzymes in cancer, kidney disease

Cannabis use during adolescence linked to greater risk of illegal substance abuse in early adulthood

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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