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Therapeutic small molecules safely prevent blood clots without excessive bleeding

It may be possible to disrupt harmful blood clots in people at risk for heart attack or stroke without increasing their risk of bleeding, according to a new study published in Nature Communications.

31 May 2017

MGH scientists show how Shigella survives journey from mouth to the colon

Surviving the treacherous journey through the human body from the mouth to the colon takes a special kind of bacterial pathogen.

31 May 2017

Internet withdrawal causes physiological changes in digitally-dependent people

Scientists and clinicians from Swansea and Milan have found that some people who use the internet a lot experience significant physiological changes such as increased heart rate and blood pressure when they finish using the internet.

31 May 2017

Sugar sponges could one day serve as treatment for diabetes

Many diabetes patients must inject themselves with insulin, sometimes several times a day, while others take medications orally to control blood sugar.

31 May 2017

Combining oral drug with personalized cell therapy can lead to complete remission in CLL patients

Combining the kinase inhibitor ibrutinib with an investigational personalized cellular therapy known as CTL119 can lead to complete remission in patients with high-risk chronic lymphocytic leukemia (CLL), according to new research from the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center

31 May 2017

TB germs' metabolic 'escape pathways' may be neutralized by new drugs to shorten duration of therapy

New research suggests the bacteria that cause tuberculosis alter their metabolism to combat exposure to antimicrobials, and that these metabolic "escape pathways" might be neutralized by new drugs to shorten the troublesome duration of therapy.

31 May 2017

Dutch scientists design self-destroying nanomotors to deliver and release drugs

Autonomous targeting and release of drugs at their site of action are desired features of nanomedical systems. Now, a team of Dutch scientists has designed a nanomotor that has these functions: An antitumor drug encapsulated in self-propelled, self-assembled stomatocytes is carried across the cellular membrane and released inside the cell upon a chemical redox signal that disassembles the vesicle membrane.

31 May 2017

Radboudumc, iMM Lisboa, PATH team up to test new malaria vaccine concept

The Radboud University Medical Center in the Netherlands, the Instituto de Medicina Molecular Lisboa in Portugal, and PATH in Seattle, Washington announced today that they will collaborate to test a new approach to malaria vaccine development in humans for the first time.

31 May 2017

Rice University scientists develop and evaluate analogs of potent cancer fighters

Rice University scientists have developed and evaluated analogs of potent anti-tumor agents known as epothilones using designs and methods that both improve their biological properties and simplify their manufacture.

31 May 2017

Study finds opioid dependence and overdose rates after urologic surgery

About 1 in 1,111 patients who undergo urologic surgery for conditions such as prostate cancer and kidney stones experience opioid dependence or overdose (ODO), a Loyola Medicine study has found.

30 May 2017

First generic version of drug to treat ADHD receives FDA approval

The U.S. Food and Drug Administration today approved the first generic versions of Strattera (atomoxetine) to treat attention-deficit/hyperactivity disorder (ADHD) in pediatric and adult patients.

30 May 2017

Fixed-dose combination therapy for high blood pressure linked to lower health services costs

About half of patients diagnosed with high blood pressure will need their medication adjusted within the first year to address side effects or failure to control blood pressure properly.

30 May 2017

Investigational compound inhibits cancer-specific mutations in mice

Many malignancies develop as a result of genetic alterations in individual cells. These gene mutations often cause altered proteins that give new, growth-promoting properties to the cell.

30 May 2017

Research findings may pave way for miracle drug to treat narcolepsy

Narcolepsy, a serious sleep disorder in which patients often fall asleep uncontrollably, has been incurable because no effective therapeutic agents are available to date. Recent findings by Japanese scientists in the sleep institute may shed light on this challenging problem.

30 May 2017

Drug rebates reward industry players — and often hurt patients

Medicare and its beneficiaries aren't the winners in the behind-the-scenes rebate game played by drugmakers, health insurers and pharmacy benefit managers, according to a paper published Tuesday in JAMA Internal Medicine.

30 May 2017

Target of Medicare insider trading case boasted he was unstoppable ‘beast’

In his prime, consultant David Blaszczak bragged that he made millions for his hedge-fund clients when he predicted important Medicare funding changes.

30 May 2017

Researchers develop new mouse model that could lead to better treatment of kidney cancer

Research in the field of kidney cancer, also called renal cancer, is vital, because many patients with this disease still cannot be cured today.

30 May 2017

Quitting methamphetamine use can prevent drug-related heart damage

Quitting methamphetamine use can reverse the damage the drug causes to the heart and improve heart function in abusers when combined with appropriate medical treatment, potentially preventing future drug-related cases of heart failure or other worse outcomes, according to a study published today in JACC: Heart Failure.

30 May 2017

Beta blockers may not benefit some heart attack patients

New research challenges established medical practice that all heart attack patients should be on beta blockers.

30 May 2017

Study finds that immune factors have cardioproliferative effects

In adult mammal hearts, cardiomyoctyes do not proliferate following damage, like that caused by myocardial infarction. However, the inability to proliferate is not true for all animals, and even in mammals, cardiomyocyte proliferation is known.

30 May 2017