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Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

A new study shows that black raspberry extract can significantly lower a key measure of arterial stiffness-an indicator of cardiovascular disease. Black raspberry intake was also associated with increased levels of circulating endothelial progenitor cells (EPCs), which help repair and regenerate damaged arteries, according to the study published in Journal of Medicinal Food, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Journal of Medicinal Food website until May 28, 2016.

29 Apr 2016

Janssen gets positive CHMP opinion for IMBRUVICA (ibrutinib) to treat patients with previously untreated CLL

Janssen-Cilag International NV today announced that the Committee for Medicinal Products for Human Use of the European Medicines Agency has adopted a Positive Opinion, recommending broadening the existing marketing authorisation for ibrutinib as a single agent for the treatment of adult patients with previously untreated chronic lymphocytic leukaemia (CLL).

29 Apr 2016

Researchers report tumors can continue to grow even without supply of new blood vessels

When medication is used to shut off the oxygen supply to tumor cells, the cells adapt their metabolism in the medium term -- by switching over to producing energy without oxygen. This observation by biomedical scientists at the University of Basel and University Hospital Basel could be used for treatments that can inhibit tumor growth in the long term, as the researchers report in the latest issue of the journal Cell Reports.

29 Apr 2016

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

The discovery of long non-coding RNA (lncRNA) has dramatically changed the understanding of the biology of diseases such as cancer. The human genome contains about 20,000 protein-coding genes - less than 2 percent of the total - but 70 percent of the genome is made into non-gene-encoding RNA.

29 Apr 2016

Role of microRNAs in range of physiological activities

A group including scientists from the Florida campus of The Scripps Research Institute (TSRI) has been awarded a grant from the National Institute of Neurological Disorders and Stroke of the National Institutes of Health to study the role of microRNAs in a range of physiological activities, including memory, sleep, synapse function and movement.

28 Apr 2016

Novel spoken-language intervention could benefit children, adolescents with developmental disabilities

Sean Sawicki, who has fragile X syndrome, can be hard to understand and doesn't always have the attention span to carry on a sustained conversation. But a novel intervention developed by UC Davis MIND Institute researchers seems to be making a difference.

28 Apr 2016

Experimental cancer drug Nutlin-3 shows promise in cancelling effects of fragile X syndrome

A University of Wisconsin-Madison researcher who studies the most common genetic intellectual disability has used an experimental drug to reverse — in mice — damage from the mutation that causes the syndrome.

28 Apr 2016

Certain genetic markers linked with depression can also predict who may benefit from exercise

Call it personalized medicine for depression -- but the prescription in this case is exercise, which University of Florida Health researchers have found helps people with certain genetic traits.

28 Apr 2016

Modernization of screening methods in sperm banks could protect future children from highly heritable diseases

U.S. sperm banks perform genetic testing to screen for and disqualify carriers of a limited number of recessive disease mutations, but more comprehensive and affordable DNA-based screening methods are now available that can detect many more disease-causing genetic variations.

27 Apr 2016

Zika virus present in Americas prior to first identification in Brazil

The Zika virus was present in Haiti several months before the first Zika cases were identified in Brazil, according to new research by infectious-disease specialists at the University of Florida.

27 Apr 2016

New rat study shows specific genetic factors may contribute to differences in addiction among humans

Why does one person who tries cocaine get addicted, while another might use it and then leave it alone? Why do some people who kick a drug habit manage to stay clean, while others relapse? And why do some families seem more prone to addiction than others?

27 Apr 2016

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

27 Apr 2016

TGen scientists trace likely origins, dispersal of fungus that causes Valley Fever

Using the latest in genomic analysis technologies, scientists at the Translational Genomics Research Institute have tracked the likely origins and dispersal of the fungus that causes Valley Fever, according to a study published today in the journal mBio, the premiere journal for reporting high impact microbiological research.

27 Apr 2016

Study reveals new function for CACNA1C gene in psychiatric diseases

A new study shows the death of newborn brain cells may be linked to a genetic risk factor for five major psychiatric diseases, and at the same time shows a compound currently being developed for use in humans may have therapeutic value for these diseases by preventing the cells from dying.

27 Apr 2016

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

A team of researchers led by the University of Leicester has shed new light on how the regulation machinery that controls gene expression works by characterising a complex known as the NuRD complex.

27 Apr 2016

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Fragile X syndrome (FXS) is the most common genetically inherited cause of intellectual disability in humans. New research shows how the hormone insulin -- usually associated with diabetes -- is involved in the daily activity patterns and cognitive deficits in the fruitfly model of FXS, according to a new study from the Perelman School of Medicine at the University of Pennsylvania published online this month in Molecular Psychiatry in advance of the print issue.

27 Apr 2016

Combination of nanoscale topography and triculture technology benefits large or slow-healing wounds

Large or slow-healing wounds that do not receive adequate blood flow could benefit from a novel approach that combines a nanoscale graft onto which three different cell types are layered. Proper cell alignment on the nanograft allows for the formation of new blood vessel-like structures, as reported in of Tissue Engineering, Part A, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free for download on the Tissue Engineering website until May 26, 2016.

27 Apr 2016

First small molecule targeted therapy holds promise for Usher syndrome

Usher syndrome (USH) is characterized by hearing loss or deafness at birth and progressive vision loss, and is the most common cause of inherited dual sensory deficit. No treatment is currently available to stop or slow the progression of vision or hearing loss in USH3, one of three clinical classifications for USH that are further divided into subtypes and all associated with different genes.

27 Apr 2016

OSMR gene plays key role in driving growth of glioblastoma tumors

Glioblastoma is the most aggressive type of brain tumor in adults. Unfortunately, there are no effective treatments for the disease. On average, patients succumb just 16 months after diagnosis.

27 Apr 2016

Researchers discover gene that plays vital role in inherited eye disorder

Researchers from the University of Liverpool have identified a specific gene that plays a key role in an inherited eye disorder.

26 Apr 2016

Genetic News and Research

Black raspberry intake can lower key measure of arterial stiffness in patients with metabolic syndrome

Janssen gets positive CHMP opinion for IMBRUVICA (ibrutinib) to treat patients with previously untreated CLL

Researchers report tumors can continue to grow even without supply of new blood vessels

New class of cancer-driver gene may serve as unique therapeutic targets, biomarkers in TNBC

Role of microRNAs in range of physiological activities

Novel spoken-language intervention could benefit children, adolescents with developmental disabilities

Experimental cancer drug Nutlin-3 shows promise in cancelling effects of fragile X syndrome

Certain genetic markers linked with depression can also predict who may benefit from exercise

Modernization of screening methods in sperm banks could protect future children from highly heritable diseases

Zika virus present in Americas prior to first identification in Brazil

New rat study shows specific genetic factors may contribute to differences in addiction among humans

Rapamycin drug could target neural damage linked to Leigh syndrome

TGen scientists trace likely origins, dispersal of fungus that causes Valley Fever

Study reveals new function for CACNA1C gene in psychiatric diseases

University of Leicester-led researchers solve 3D structure of NuRD complex that plays role in cancer

New fruit fly model study reveals metabolic pathway that can be targeted to treat FXS patients

Combination of nanoscale topography and triculture technology benefits large or slow-healing wounds

First small molecule targeted therapy holds promise for Usher syndrome

OSMR gene plays key role in driving growth of glioblastoma tumors

Researchers discover gene that plays vital role in inherited eye disorder

Genetics & Genomics - Second Edition eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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