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New study finds way to help treat alcohol addiction and ease withdrawal symptoms

According to a new study by Scripps Research scientists, activating a receptor found in brain cells may help treat alcohol addiction and ease some withdrawal symptoms. The researchers studied the effects of activating the receptor in alcohol-addicted rats and reported the results today in the journal eNeuro.

27 Jun 2018

New avenue for cancer treatment opens when one drug fails

A new class of cancer drugs – called CDK4/6 inhibitors -- recently approved to treat breast cancer can stunt the cancer's growth and replication.

27 Jun 2018

Study shows benefits, safety of long-lasting radionuclide therapy for patients with advanced NETs

A first-in-human study presented at the 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging demonstrates the benefits and safety of a new, long-lasting type of radionuclide therapy for patients with advanced, metastatic neuroendocrine tumors.

26 Jun 2018

Learning from nature's design of mosquito to create painless microneedles

A mosquito can insert a needle-like probe into your skin and draw blood for several minutes without you even noticing.

26 Jun 2018

MIT researchers decode structure of molecule that gives tissues their elasticity

The stretchiness that allows living tissues to expand, contract, stretch, and bend throughout a lifetime is the result of a protein molecule called tropoelastin. Remarkably, this molecule can be stretched to eight times its length and always returns back to its original size.

26 Jun 2018

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

More than 60 percent of breast cancer cases involve defects in the same biochemical chain of events within cancer cells-- known as the PI3 kinase (PI3K) pathway--but efforts to develop therapies targeting this pathway have met with little success after hundreds of mostly failed clinical trials. And researchers still don't understand why.

26 Jun 2018

Microbiologists and plant scientists pinpoint genetic weakness in cholera pandemic's armor

While cholera rages across many regions of the world, a team of microbiologists and plant scientists has pinpointed a genetic weakness in the pandemic's armor, which could lead to future treatments.

26 Jun 2018

New molecular imaging method could help effectively tackle brain conditions

A new molecular imaging method can monitor the success of gene therapy in all areas of the brain, potentially allowing physicians to more effectively tackle brain conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis.

26 Jun 2018

Researchers identify novel mutation in amyloid diseases

Researchers have identified a one-of-a kind mutation in the DNA of a patient who died of transthyretin (TTR) amyloidosis, a progressive condition characterized by the buildup of abnormal deposits of a misfolded protein called amyloid in the body's organs and tissues.

26 Jun 2018

Scientists discover and characterize new toxin in cholera bacteria

The bacterium Vibrio cholerae was discovered more than 150 years ago but remains as one of the main causes of bacterial infectious disease globally, especially in low-income nations where it occurs endemic, and outbreaks of cholera disease can lead to major epidemics.

26 Jun 2018

Study suggests new approach for treating alcohol use disorder

Activation of a receptor with no known function in the brain reduces excessive alcohol use and the pain of withdrawal, according to preclinical research in male rats. The study, published in eNeuro, suggests a new approach towards the treatment of alcohol use disorder.

26 Jun 2018

Canadian researchers uncover new molecular mechanism to stop proliferation of cancer cells

Canadian researchers have discovered a new and direct molecular mechanism to stop cancer cells from proliferating. In the prestigious journal Nature Cell Biology, scientists from Université de Montréal show that a disruption of a fine balance in the composition of ribosomes (huge molecules that translate the genetic code into proteins) results in a shutdown of cancer cell proliferation, triggering a process called senescence.

26 Jun 2018

Targeting proteins in semen could prevent sexually transmitted spread of Ebola virus

Protein fragments, called amyloid fibrils, in human semen significantly increase Ebola virus infection and protect the virus against harsh environmental conditions such as heat and dehydration. Researchers from the Perelman School of Medicine at the University of Pennsylvania report these findings in a study published this week in the Proceedings of the National Academy of Sciences.

26 Jun 2018

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

25 Jun 2018

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

AbbVie , a research-based global biopharmaceutical company, and Calibr, a nonprofit drug discovery division of Scripps Research, today announced a collaboration to develop T-cell therapies aimed primarily at cancer, including solid tumors.

25 Jun 2018

Researchers discover immune profile for effective cancer immunotherapy

In a new study published online June 25, 2018 in Nature Medicine, UC San Francisco researchers have identified a key biological pathway in human cancer patients that appears to prime the immune system for a successful response to immunotherapy drugs known as checkpoint inhibitors.

25 Jun 2018

Protein C News and Research

New study finds way to help treat alcohol addiction and ease withdrawal symptoms

New avenue for cancer treatment opens when one drug fails

Study shows benefits, safety of long-lasting radionuclide therapy for patients with advanced NETs

Learning from nature's design of mosquito to create painless microneedles

MIT researchers decode structure of molecule that gives tissues their elasticity

Unbiased approach reveals how to restore breast cancer drugs’ tumor-killing potential

Microbiologists and plant scientists pinpoint genetic weakness in cholera pandemic's armor

New molecular imaging method could help effectively tackle brain conditions

Researchers identify novel mutation in amyloid diseases

Scientists discover and characterize new toxin in cholera bacteria

Study suggests new approach for treating alcohol use disorder

Canadian researchers uncover new molecular mechanism to stop proliferation of cancer cells

Targeting proteins in semen could prevent sexually transmitted spread of Ebola virus

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

AbbVie and Calibr collaborate to develop T-cell therapies aimed at cancer

Researchers discover immune profile for effective cancer immunotherapy

Researchers work on new treatment that could improve lives of cystic fibrosis patients

New discovery suggests potential target for treating cancers and other diseases

Study links molecular changes in the brain to key behaviors in addiction

Researchers use gene editing to reduce autism symptoms in mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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