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New methods of fragment-based lead discovery to identify potential antibiotics

In the July 2018 issue of SLAS Discovery, a review article summarizes new methods of fragment-based lead discovery to identify new compounds as potential antibiotics.

21 Jun 2018

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Aquinnah Pharmaceuticals, leaders in stress granule biology, an exciting new target for the development of neurodegenerative therapeutics, announced today that it has been awarded $3.4 million from the National Institute of Neurological Disorders and Stroke in a competing grant to advance novel therapeutic drug candidates towards the clinic for treating patients with amyotrophic lateral sclerosis, also known as Lou Gehrig's disease.

21 Jun 2018

Researchers uncover new therapeutic opportunity in the treatment of malignant melanoma

A team of researchers led by Dr Pierre Close, WELBIO researcher at the ULiège GIGA Institute and Dr Francesca Rapino has uncovered a new therapeutic opportunity in the treatment of malignant melanoma that acquired resistance to targeted therapies.

21 Jun 2018

Study unravels new piece of information in the Huntington’s disease puzzle

In a new study, researchers from the University of Copenhagen have discovered a hitherto unknown error in the transport of glutamine between astrocytes and neurons in the brain of mice with Huntington's disease.

21 Jun 2018

Fetal immune cells are fast-acting first responders to microbes in adulthood

Cornell University researchers have discovered there is a division of labor among immune cells that fight invading pathogens in the body.

20 Jun 2018

UT Southwestern scientists identify gene mutation linked with perplexing brain condition

Scientists conducting one of the largest full DNA analyses of a rare disease have identified a gene mutation associated with a perplexing brain condition that blinds and paralyzes patients.

20 Jun 2018

Multidisciplinary Human-Focused Research

The work that we're doing in particular involves the development of better models of the human body. To do that, we need to put together cells, tissues, culture them in an artificial environment so that they feel as if they're inside the human body.

From Logos Biosystems 20 Jun 2018

Researchers use advanced technology to identify proteomes of Th17 and iTreg cells

T helper 17 (Th17) cells belong to a group of T cells with essential functions in autoimmune diseases and inflammation. Regulatory T cells (iTregs) are T cells with a suppressive function to maintain self-tolerance and prevent autoimmune responses.

20 Jun 2018

Study provides insights into how components of different cells in the brain are altered

Scientists have revealed that protein molecules in the brain are broken down and replaced at different rates, depending on where in the brain they are.

20 Jun 2018

Increasing biodefense risks posed by synthetic biology

A US Department of Defense commissioned study has found that there are several genetic-engineering tools that could be used to devise biological weapons in a short amount of time.

19 Jun 2018

Loyola Medicine study: Floppy eyelids linked to sleep apnea

A Loyola Medicine study is providing further evidence that floppy eyelids may be a sign of sleep apnea.

19 Jun 2018

Low blood levels of vitamin D linked to increased risk of interstitial lung disease

Reviewing medical information gathered on more than 6,000 adults over a 10-year period, Johns Hopkins researchers have found that lower than normal blood levels of vitamin D were linked to increased risk of early signs of interstitial lung disease.

19 Jun 2018

Cells form cage-like structures that trap viruses, find scientists

Scientists have shown that cells can form cage-like structures around viruses to trap them and prevent them from spreading to nearby cells.

19 Jun 2018

Scientists create universal assembly method to enhance cancer therapy and diagnostics

Biophysicists have developed a method for modifying the surface of micro- and nanoparticles — tiny structures measuring between a thousandth and a millionth of a millimeter — by covering them with biological molecules. Engineered in this way, the particles can serve as both therapeutic and diagnostic agents, delivering drugs to cancer cells.

19 Jun 2018

Chemists invent new method for remote chiral induction

Chemists at Scripps Research have addressed one of the most formidable challenges in synthetic chemistry by inventing a method for "enantioselective remote meta-CH activation," which enables the making of chiral molecules that were previously difficult or impossible to synthesize.

19 Jun 2018

Researchers use droplet-sized 'miniecosystems' to test therapeutic potential of molecules

Scripps Research scientists have solved a major problem in chemistry and drug development by using droplet-sized 'miniecosystems' to quickly see if a molecule can function as a potential therapeutic.

19 Jun 2018

Scientists obtain key information about proteins from single human cells

Scientists have obtained a slew of key information about proteins, the molecular workhorses of all cells, from single human cells for the first time.

19 Jun 2018

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

In vitro fertilization affects the regulatory region of genes essential for placental and embryonic growth, as well as the birth weight.

19 Jun 2018

Researchers use optogenetics to shape tissues

Constructing biological tissues, such as skin, muscle, or bone, in customized shapes is now one step closer.

19 Jun 2018

Scientists point to potentially promising treatment target for deadly brain cancers

Scientists report finding a potentially promising treatment target for aggressive and deadly high-grade brain cancers like glioblastoma. But they also say the current lack of a drug that hits the molecular target keeps it from being advanced for testing as a therapeutic strategy for patients with few treatment options.

18 Jun 2018

Protein C News and Research

New methods of fragment-based lead discovery to identify potential antibiotics

Aquinnah Pharmaceuticals wins NINDS grant to advance novel therapies for ALS

Researchers uncover new therapeutic opportunity in the treatment of malignant melanoma

Study unravels new piece of information in the Huntington’s disease puzzle

Fetal immune cells are fast-acting first responders to microbes in adulthood

UT Southwestern scientists identify gene mutation linked with perplexing brain condition

Multidisciplinary Human-Focused Research

Researchers use advanced technology to identify proteomes of Th17 and iTreg cells

Study provides insights into how components of different cells in the brain are altered

Increasing biodefense risks posed by synthetic biology

Loyola Medicine study: Floppy eyelids linked to sleep apnea

Low blood levels of vitamin D linked to increased risk of interstitial lung disease

Cells form cage-like structures that trap viruses, find scientists

Scientists create universal assembly method to enhance cancer therapy and diagnostics

Chemists invent new method for remote chiral induction

Researchers use droplet-sized 'miniecosystems' to test therapeutic potential of molecules

Scientists obtain key information about proteins from single human cells

Study: Effects of in vitro fertilization depend on genetic variation inherited from parents

Researchers use optogenetics to shape tissues

Scientists point to potentially promising treatment target for deadly brain cancers

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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