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Guardant Health introduces new initiative to sequence tumor DNA of one million cancer patients

Guardant Health, the world leader in comprehensive liquid biopsies, announced an ambitious goal to sequence the tumor DNA of more than 1 million cancer patients within five years.

15 May 2017

European researchers set up new network to boost use of MRI biomarkers in managing kidney disease

Researchers from 22 European countries have set up PARENCHIMA, a network that will boost the use of magnetic resonance imaging biomarkers in efficiently managing chronic kidney disease.

15 May 2017

Study sheds new light on inherent ability of normal cells to prevent cancer at the initial stage

A new study shows cells in the initial stage of cancer change their metabolism before getting eliminated by the surrounding normal cells, providing a novel target for developing cancer prevention drugs.

15 May 2017

Research findings provide insight into mechanisms underlying differences in efficacy of anti-TNF drugs

Osaka University-led researchers identified differences in how three drugs bind to tumor necrosis factor, a key mediator of inflammatory disease. The team used sedimentation velocity analytical ultracentrifugation to investigate drug-target binding in a physiological environment and at clinically-relevant concentrations.

15 May 2017

Study findings could pave way for better drugs to fight against parasitic infections

Immune cells, called macrophages, may rely on a compound to signal an attack to beat back attacks from parasitic worms, according to an international team of researchers, including Zissis C. Chroneos, associate professor of pediatrics, and microbiology and immunology at Penn State College of Medicine.

12 May 2017

FDA approves use of new Flourish device to treat infants born with esophageal atresia

The U.S. Food and Drug Administration today authorized use of the Flourish Pediatric Esophageal Atresia Anastomosis, a first-of-its-kind medical device to treat infants up to one year old for a birth defect that causes a gap in their esophagus, called esophageal atresia.

12 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

In the body, anti-cancer immunity is immobilized by stealth cancer forces. But a natural de-immobilizer has been identified - and it has a vendetta.

12 May 2017

Analyzing single-cell RNA data in pre-malignant tumors

RNA sequencing is basically the isolation of RNA from cells and the use of reverse transcriptase to turn the RNA into DNA. You can then use your standard DNA sequencing technologies to quantify the cDNA that you obtained from the reverse transcription reaction.

12 May 2017

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.

12 May 2017

Research findings identify protein as potential new drug target for HCMV infections

Scientists have demonstrated that a human protein known as valosin containing protein (VCP) is essential for replication of human cytomegalovirus. The findings, published in PLOS Pathogens, identify VCP as a potential new treatment target.

11 May 2017

Study finds substantial increase in hepatitis C infections among pregnant women

Hepatitis C infections among pregnant women nearly doubled from 2009-2014, likely a consequence of the country's increasing opioid epidemic that is disproportionately affecting rural areas of states including Tennessee and West Virginia.

11 May 2017

Scientists reveal how immune cells activate to kill parasitic worms

An international team of researchers including Zissis C. Chroneos, associate professor of pediatrics, and microbiology and immunology at Penn State College of Medicine, reveals how immune cells called macrophages activate to kill parasitic worms.

11 May 2017

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

The low oxygen concentrations that prevail in many tumors enhance their propensity to metastasize to other tissues. Researchers at Ludwig-Maximilians-Universitaet in Munich led by Professor Heiko Hermeking have now uncovered the molecular mechanism that links the two phenomena.

11 May 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Study shows link between susceptibility to malignant hyperthermia and exertional heat stroke

New research published online in The FASEB Journal may ultimately help athletes and trainers better understand who may be more at risk for heat stroke.

11 May 2017

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

New research published online in The FASEB Journal suggests that the suppression of thyroid hormone receptor activity locally in the retina protects cone photoreceptor cells in mouse models of human retinal degenerative diseases

11 May 2017

Introduction of ART has increased life expectancy in HIV patients by 10 years

A study published in the journal The Lancet HIV has found an increase in life expectancy of 20-year-old HIV patients in the EU and North America who had started antiretroviral therapy (ART) after it was introduced mid-1990s. When compared with patients who were not treated with ART, the life expectancy had increased by around a decade in these patients.

11 May 2017

Large source of real-time data provides insight into treatment for vision-threatening condition

For most people, being nearsighted is a nuisance, easily treated with a prescription for glasses or contact lenses. But some experience a complication that can cause permanent blindness.

11 May 2017

Study: Drug-resistant tuberculosis predicted to increase in four high burden countries

Cases of drug-resistant tuberculosis are forecasted to increase in the four high burden countries (India, the Philippines, Russia, and South Africa) between 2000 and 2040, with the upturn likely to be a result of increased transmission of drug-resistant tuberculosis between people, rather than by strains acquiring resistance to anti-tuberculosis drugs, according to a study published in The Lancet Infectious Diseases.

11 May 2017

Drugs News and Research

Guardant Health introduces new initiative to sequence tumor DNA of one million cancer patients

European researchers set up new network to boost use of MRI biomarkers in managing kidney disease

Study sheds new light on inherent ability of normal cells to prevent cancer at the initial stage

Research findings provide insight into mechanisms underlying differences in efficacy of anti-TNF drugs

Study findings could pave way for better drugs to fight against parasitic infections

FDA approves use of new Flourish device to treat infants born with esophageal atresia

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

Analyzing single-cell RNA data in pre-malignant tumors

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Research findings identify protein as potential new drug target for HCMV infections

Study finds substantial increase in hepatitis C infections among pregnant women

Scientists reveal how immune cells activate to kill parasitic worms

LMU scientists uncover molecular mechanism that links tumor hypoxia and metastasis

CUMC researchers create new organoids that mimic features of full-sized lung

Study shows link between susceptibility to malignant hyperthermia and exertional heat stroke

Suppression of thyroid hormone receptor protects cone cells in mouse models of retinal diseases

Introduction of ART has increased life expectancy in HIV patients by 10 years

Large source of real-time data provides insight into treatment for vision-threatening condition

Study: Drug-resistant tuberculosis predicted to increase in four high burden countries

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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