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Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

One in 5,000 babies is born missing a small amount of genetic material from the tip of chromosome 1, a region called 1p36. Missing genes in the 1p36 region is a relatively common cause of intellectual disability.

18 Apr 2016

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

In a small, phase I clinical trial, Johns Hopkins Kimmel Cancer Center researchers say they show for the first time that the experimental drug guadecitabine (SGI-110) is safe in combination with the chemotherapy drug irinotecan and may overcome resistance to irinotecan in patients with metastatic colorectal cancer.

18 Apr 2016

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

While research has identified hundreds of genes required for normal memory formation, genes that suppress memory are of special interest because they offer insights into how the brain prioritizes and manages all of the information, including memories, that it takes in every day.

18 Apr 2016

Researchers find that children develop self-control mechanisms by age 3

University of Texas at Arlington researchers have found that by age 3 environmental influences such as parenting are relevant factors in the development of toddlers' self-control when they are asked not to do something they want to do, such as run into the street or eat a forbidden snack.

16 Apr 2016

Scientists identify human protein that weakens immune response to HIV, other viruses

Scientists at the University of North Carolina School of Medicine and Sanford Burnham Prebys Medical Discovery Institute have identified a human (host) protein that weakens the immune response to HIV and other viruses. The findings, published today in Cell Host & Microbe, have important implications for improving HIV antiviral therapies, creating effective viral vaccines, and advance a new approach to treat cancer.

16 Apr 2016

Radiation plus chemotherapy improves survival of low-grade brain cancer patients

New clinical-trial findings show that patients with a low-grade form of brain cancer who are treated with radiation plus a combination of chemotherapy drugs have better survival than patients treated with radiation alone.

16 Apr 2016

Mouse model offers insight into molecular, neurological basis of stuttering

Mice that vocalize in a repetitive, halting pattern similar to human stuttering may provide insight into a condition that has perplexed scientists for centuries, according to a new study by researchers at Washington University School of Medicine in St. Louis and the National Institutes of Health.

16 Apr 2016

Genetic modification of common virus gives extra weapon to kill cancer cells

A common flu virus could be used to overcome patients' resistance to certain cancer drugs -- and improve how those drugs kill cancer cells, according to new research from Queen Mary University of London.

16 Apr 2016

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

New research in laboratory animals suggests that the drug palovarotene may prevent multiple skeletal problems caused by a rare but extremely disabling genetic bone disease, and may even be a candidate for use in newborn babies with the condition.

15 Apr 2016

Growth chart of brain networks could spot early signs of attention difficulties in children

Want to know if your child's height and weight are on track? Check the growth chart that the doctor gives you after each yearly checkup.

15 Apr 2016

UNIGE researchers identify PIGG gene that plays crucial role in recessive disease

The objective of genetic medicine is to analyze all the genes that make up the human genome, in order to identify as many genetic diseases as possible. Indeed, each gene variation has the potential to trigger specific defects.

15 Apr 2016

Home screening for bowel cancer: an interview with Deborah Alsina, Chief Executive of Bowel Cancer UK

FIT (faecal immunochemical test) is a screening test for bowel cancer which detects hidden traces of blood in stools. It is now used in population screening around the world including Italy, The Netherlands, France, Ireland, New Zealand, Australia, Spain, Slovenia, Malta, Japan, parts of Canada, and Southeast Asia.

14 Apr 2016

Oxford Gene Technology develops new FISH probes in ‘outstanding’ Innovate UK project

Oxford Gene Technology (OGT), The Molecular Genetics Company, has developed a new range of non-human fluorescence in situ hybridisation (FISH) probes, for pig, chicken and mouse. The probes were developed as part of an Innovate UK knowledge transfer partnership (KTP) funded project in collaboration with the University of Kent, and was given an ‘outstanding’ award reserved for the top 10% of KTP projects.

13 Apr 2016

TDF, entecavir duo 'highly effective' for difficult-to-treat chronic HBV

The combination of tenofovir disoproxil fumarate and entecavir induces a high rate of viral suppression in patients with chronic hepatitis B virus infection who have failed multiple nucleos(t)ide analogue regimens, phase IIIb results indicate.

13 Apr 2016

Study shows how homosexuality exists among humans throughout history

Around half of all heterosexual men and women potentially carry so-called homosexuality genes that are passed on from one generation to the next. This has helped homosexuality to be present among humans throughout history and in all cultures, even though homosexual men normally do not have many descendants who can directly inherit their genes.

13 Apr 2016

Scientists use FAN1 knockout mice to refine detailed mechanisms involved in damaged DNA repair

Like jewels in a vault, our precious genetic material is stored in the nucleus of a cell--sequestered away from potentially damaging cellular components and toxins so that no harm can come to it. Yet over the course of a life moving through this world, our DNA does get damaged, and our cells have a host of complicated repair mechanisms to deal with such injuries.

13 Apr 2016

Researchers observe increase in antibiotic resistance genes

Around the world, antibiotic use and resistance is increasing while the discovery of new antibiotics has nearly halted.

13 Apr 2016

Manipulation of signals in nervous system can enhance recovery after traumatic injury

Neurobiologists at UC San Diego have discovered how signals that orchestrate the construction of the nervous system also influence recovery after traumatic injury. They also found that manipulating these signals can enhance the return of function.

12 Apr 2016

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Many bacteria interact with their environment through hair-like structures known as pili, which attach to and help mediate infection of host organisms, among other things. Now a U.S.-Japanese research team, including scientists from the Department of Energy's SLAC National Accelerator Laboratory, has discovered that certain bacteria prevalent in the human gut and mouth assemble their pili in a previously unknown way - information that could potentially open up new ways of fighting infection.

12 Apr 2016

Study assesses risk factors for metastases in prostate cancer patients on active surveillance

Radical treatment such as surgery and radiation for localized prostate cancer may cause significant side effects. Active surveillance is increasingly accepted as an option for treating patients with clinically insignificant disease to maintain their quality of life.

12 Apr 2016

Genetic News and Research

Researchers determine mutations in RERE gene can cause many features linked with 1p36 deletions

Study shows safety of experimental drug guadecitabine in colorectal cancer patients

Scientists identify unique memory suppressor gene that could provide clues for new Alzheimer’s disease treatments

Researchers find that children develop self-control mechanisms by age 3

Scientists identify human protein that weakens immune response to HIV, other viruses

Radiation plus chemotherapy improves survival of low-grade brain cancer patients

Mouse model offers insight into molecular, neurological basis of stuttering

Genetic modification of common virus gives extra weapon to kill cancer cells

Palovarotene drug may prevent multiple musculoskeletal problems linked with FOP

Growth chart of brain networks could spot early signs of attention difficulties in children

UNIGE researchers identify PIGG gene that plays crucial role in recessive disease

Home screening for bowel cancer: an interview with Deborah Alsina, Chief Executive of Bowel Cancer UK

Oxford Gene Technology develops new FISH probes in ‘outstanding’ Innovate UK project

TDF, entecavir duo 'highly effective' for difficult-to-treat chronic HBV

Study shows how homosexuality exists among humans throughout history

Scientists use FAN1 knockout mice to refine detailed mechanisms involved in damaged DNA repair

Researchers observe increase in antibiotic resistance genes

Manipulation of signals in nervous system can enhance recovery after traumatic injury

Bacteroidia pilins prevalent in human gut and mouth form new type of pili to cling to hosts

Study assesses risk factors for metastases in prostate cancer patients on active surveillance

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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