Chromosome 3 News and Research

RSS

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 3, one copy inherited from each parent, form one of the pairs. Chromosome 3 spans almost 200 million base pairs (the building blocks of DNA) and represents approximately 6.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 3 likely contains between 1,100 and 1,500 genes.

Genes on chromosome 3 are among the estimated 20,000 to 25,000 total genes in the human genome.

Two studies on childhood leukemia

A difficult-to-treat form of childhood leukemia relies on changes in the structure of DNA - so-called epigenetic changes - to wreak genomic havoc within white blood cells, according to one of two studies conducted by a research team at Children's Hospital Boston and Dana-Farber Cancer Institute.

12 Jul 2011

Illumina, Sequenom sign three-year supply agreement

Sequenom, Inc., a life sciences company providing innovative genetic analysis solutions, today announced it has signed a three-year supply agreement with Illumina, Inc., a leading developer and manufacturer of life sciences tools for the large-scale analysis of genetic variation and function.

From Illumina, Inc. 11 Jul 2011

Scientists discover seven new gene variants that increase risk of prostate cancer

Cancer Research UK-funded scientists have taken a further step to identifying men at a greater risk of prostate cancer with the discovery of seven new variants in the human genome that increase the chances of developing the disease.

11 Jul 2011

Primary function of sex is not to promote diversity, but to maintain a species' identity

Biology textbooks maintain that the main function of sex is to promote genetic diversity. But Henry Heng, Ph.D., associate professor in WSU's Center for Molecular Medicine and Genetics, says that's not the case.

8 Jul 2011

New strategy may combat age-associated infertility and birth defects

A strategy that has been shown to reduce age-related health problems in several animal studies may also combat a major cause of age-associated infertility and birth defects.

8 Jul 2011

Cumulus cells can provide information about genetic and chromosomal status of eggs

At present, when a woman undergoes preimplantation genetic screening (PGS) in a fertility clinic, doctors are trying to select an egg or an embryo that is healthy and doesn't have a chromosome abnormality such as an extra copy of chromosome 21, which causes Down's syndrome. In order to establish this, they either have to biopsy a part of the egg called the polar body or remove a cell from the embryo for screening. Both procedures are expensive, invasive and can damage the egg or embryo.

6 Jul 2011

Review of non-smoker patient with lung cancer to be presented at IASLC conference

A first-of-its-kind study of a patient with lung cancer who never smoked will be presented today by TGen and the Virginia G. Piper Cancer Center at Scottsdale Healthcare at the 14th World Conference on Lung Cancer, July 3-7 in Amsterdam.

6 Jul 2011

Cleavage stage embryo with aneuploidy can undergo genetic normalisation process

Professor William G. Kearns told the annual meeting of the European Society of Human Reproduction and Embryology that a three-day-old embryo with an incorrect number of chromosomes was capable of undergoing "a dynamic process of genetic normalisation" so that by day five, when it had developed to the blastocyst stage, it had become euploid, with the correct number of chromosomes.

5 Jul 2011

Fruit flies with poor posture help scientists understand human intellectual disability

Clumsy fruit flies with poor posture are helping an international team of scientists understand inherited intellectual disability in humans - and vice versa.

5 Jul 2011

New insight into oocyte chromosome abnormalities

Ovarian stimulation undertaken by women of advanced maternal age receiving fertility treatment may be disrupting the normal pattern of meiosis - a critical process of chromosome duplication followed by two specialised cell divisions in the production of oocytes and sperm - and leading to abnormalities of chromosome copy numbers that result in IVF failure, pregnancy loss or, more rarely, the birth of affected children with conditions such as Down's syndrome, which is caused by the inheritance of three copies of chromosome 21.

4 Jul 2011

Scientists discover enzyme that can regulate breast cancer development

Researchers at Cold Spring Harbor Laboratory (CSHL) have identified an enzyme that appears to be a significant regulator of breast cancer development. Called PTPN23, the enzyme is a member of a family called protein tyrosine phosphatases, or PTPs, that plays a fundamental role in switching cell signaling on and off.

1 Jul 2011

USPTO awards patent for key therapeutic ingredient in CNVN202 targeted molecular cancer therapy

Convergen LifeSciences, Inc. announced today that a United States Patent has been awarded by the U.S. Patent and Trademark Office jointly to The University of Texas System Board of Regents and The Secretary, U.S. Department of Health and Human Services.

29 Jun 2011

Health Canada approves Tasigna for newly diagnosed Philadelphia chromosome-positive CML

Over a decade ago, Canadian patients diagnosed with chronic myeloid leukemia (CML), celebrated when PrGleevec (imatinib mesylate) was approved in Canada.

27 Jun 2011

Study links genetic variants in MHC region with risk of lupus in African American women

Researchers from Boston University's Slone Epidemiology Center have found four new genetic variants in the major histocompatibility complex (MHC) that confer a higher risk of systemic lupus erythemathosus in African American women.

27 Jun 2011

In vivo genome editing restores hemostasis in mouse model of blood clotting disorder

Using an innovative gene therapy technique called genome editing that hones in on the precise location of mutated DNA, scientists have treated the blood clotting disorder hemophilia in mice.

27 Jun 2011

CBMi creates iPad app for exploring human genomic information

Navigating the human genome with software that you can view on an iPad® sounds pretty impressive, until perhaps you reflect that nature has already encoded trillions of copies of this in your chromosomes. Then again, printing that data using ink and paper would produce a mind-staggering pile of pages—so viewing it on an iPad® may be impressive after all.

24 Jun 2011

AIS introduces Spectral karyotyping

AIS introduces Spectral karyotyping (SKY®) equipment, designed and manufactured by ASI, a leading developer of comprehensive solutions for pathology and cytogenetics. Spectral karyotyping (SKY®) is ASI’s novel addition to the cytogenetic tool kit. It is based on a unique electro-optical hardware that enables measuring the spectral image of a metaphase, previously stained, such that each chromosome class has a different color (created typically from different combinations of 5 or more basic dyes).

23 Jun 2011

Nine young clinical investigators earn recognition from Damon Runyon Cancer Research Foundation

The Damon Runyon Cancer Research Foundation named five new Damon Runyon Clinical Investigators at its spring 2011 Clinical Investigator Award Committee review.

22 Jun 2011

Genetic mutation linked to peripartum cardiomyopathy during pregnancy

Researchers at the Intermountain Medical Center Heart Institute in Salt Lake City have identified the first genetic mutation ever associated with a mysterious and potentially devastating form of heart disease that affects women in the final weeks of pregnancy or the first few months after delivery.

22 Jun 2011

BGI releases first complete map of Germany E. coli O104:H4 genome

Building upon previous efforts producing a high-quality de novo genome assemblies of deadly 2011 E. coli O104:H4 outbreak strain, the BGI and their collaborators at the University Medical Centre Hamburg-Eppendorf have now released the first complete map of the genome and plasmids without any assembly gaps.

17 Jun 2011

Chromosome 3 News and Research

Further Reading

Two studies on childhood leukemia

Illumina, Sequenom sign three-year supply agreement

Scientists discover seven new gene variants that increase risk of prostate cancer

Primary function of sex is not to promote diversity, but to maintain a species' identity

New strategy may combat age-associated infertility and birth defects

Cumulus cells can provide information about genetic and chromosomal status of eggs

Review of non-smoker patient with lung cancer to be presented at IASLC conference

Cleavage stage embryo with aneuploidy can undergo genetic normalisation process

Fruit flies with poor posture help scientists understand human intellectual disability

New insight into oocyte chromosome abnormalities

Scientists discover enzyme that can regulate breast cancer development

USPTO awards patent for key therapeutic ingredient in CNVN202 targeted molecular cancer therapy

Health Canada approves Tasigna for newly diagnosed Philadelphia chromosome-positive CML

Study links genetic variants in MHC region with risk of lupus in African American women

In vivo genome editing restores hemostasis in mouse model of blood clotting disorder

CBMi creates iPad app for exploring human genomic information

AIS introduces Spectral karyotyping

Nine young clinical investigators earn recognition from Damon Runyon Cancer Research Foundation

Genetic mutation linked to peripartum cardiomyopathy during pregnancy

BGI releases first complete map of Germany E. coli O104:H4 genome

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Latest News