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Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Researchers described four novel monoclonal antibodies with potent and broad neutralization activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, including the current globally dominant Omicron BA.4/BA.5.

20 Dec 2022

Dapagliflozin improves morbidity reduces risk of death in heart failure patients

Researchers investigate the safety and efficacy of dapagliflozin among heart failure patients with improved ejection fraction.

19 Dec 2022

First H5N3 infection in a captive emperor tamarin documented in new study

In a new study, researchers reported the first H5N3 infection in a captive Emperor Tamarin.

19 Dec 2022

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

Researchers demonstrated that a trivalent vaccine against SARS-CoV-2 improved the breadth of humoral immune responses in mice.

19 Dec 2022

Exploring taste and smell dysfunction as strong predictors of SARS-CoV-2 infections

Researchers investigated whether coronavirus disease 2019 (COVID-19)-associated chemosensory alterations were predictive of serological responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among United States (US) residents.

16 Dec 2022

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers investigated the cellular tropism, replication competence, persistence and evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in humans, and associated histopathological changes in infected tissues.

16 Dec 2022

Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines

Researchers developed a one-dose subunit vaccine for the induction of durable, potent, and broad immunity against SARS-CoV-2.

16 Dec 2022

Common psychiatric medications can give some protection against COVID-19

A new meta-analysis shows that psychiatric medications can give some protection against COVID-19, with the common antidepressant fluvoxamine showing the strongest effect.

16 Dec 2022

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Researchers demonstrated the exceptional immune evasion properties of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants, BQ and XBB.

16 Dec 2022

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

Pancreatic cancer remains one of the deadliest malignancies worldwide. Since five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only about 3% in patients, PDAC is very difficult to treat with surgery worldwide.

16 Dec 2022

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Scientists identify an immunogenic epitope at the furin cleavage site of the SARS-CoV-2 spike protein.

15 Dec 2022

Researchers discover previously unknown mechanism for how 'starvation response' is triggered

Body cells burn off fat reserves when nutrient supply from food ceases. A team led by Professor Volker Haucke and Dr. Wonyul Jang from the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) has now discovered a previously unknown mechanism for how this “starvation response” is triggered, and what can inhibit it.

15 Dec 2022

Novel machine learning method detects animal coronaviruses that might infect humans

Researchers used machine learning (ML) tools to discover animal coronaviruses (CoVs), both alpha and beta CoVs, previously unknown to infect humans.

15 Dec 2022

New clue may explain why women are at greater risk for Alzheimer's disease

Scientists at Scripps Research and Massachusetts Institute of Technology (MIT) have found a clue to the molecular cause of Alzheimer's - a clue that may also explain why women are at greater risk for the disease.

15 Dec 2022

UBC researchers identify a compound that shows early promise at halting viral infections

Researchers at UBC's Life Sciences Institute have identified a compound that shows early promise at halting infections from a range of coronaviruses, including all variants of SARS-CoV-2 and the common cold.

15 Dec 2022

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Researchers used sheep, a ruminant mammal, to obtain polyclonal immunoglobulins (IgGs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Dec 2022

Research reveals that a viral toxin may contribute to the severity of COVID-19

Researchers determine whether the SARS-CoV-2 spike protein influences endothelial and epithelial barrier dysfunction and vascular leakage.

14 Dec 2022

Study finds a novel therapeutic target for prevention and treatment of gout

Many Americans think of gout as a disease from a bygone era, akin to rickets or scurvy. The condition commonly afflicted the rich and royal, including American historical figures such as Benjamin Franklin and Thomas Jefferson.

14 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

Researchers have characterised prostate cancer cell dynamics at a single-cell resolution across the timespan of the disease – from its beginning to the point of androgen independence, where the tumour no longer responds to hormone deprivation therapy.

14 Dec 2022

Enzyme News and Research

Study identifies four new monoclonal antibodies with broad neutralizing potencies that target conserved SARS-CoV-2 epitopes

Dapagliflozin improves morbidity reduces risk of death in heart failure patients

First H5N3 infection in a captive emperor tamarin documented in new study

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

Exploring taste and smell dysfunction as strong predictors of SARS-CoV-2 infections

Study shows SARS-CoV-2 infection, replication and persistence in human brain tissues

Researchers report the development of robust candidate single immunization PNP hydrogel COVID vaccines

Common psychiatric medications can give some protection against COVID-19

SARS-CoV-2 Omicron BQ and XBB subvariants show exceptional immune evasion properties

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

Scientists identify a novel epitope at the SARS-CoV-2 spike furin cleavage site

Researchers discover previously unknown mechanism for how 'starvation response' is triggered

Novel machine learning method detects animal coronaviruses that might infect humans

New clue may explain why women are at greater risk for Alzheimer's disease

UBC researchers identify a compound that shows early promise at halting viral infections

Sheep milk could be an inexpensive source of therapeutic polyclonal SARS-CoV-2 neutralizing antibodies

Research reveals that a viral toxin may contribute to the severity of COVID-19

Study finds a novel therapeutic target for prevention and treatment of gout

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Expansion of intermediate cells in prostate cancer correlates with treatment resistance and poor outcomes

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