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New discovery could end chronic rejection of transplanted organs

Chronic rejection of transplanted organs is the leading cause of transplant failure, and one that the field of organ transplantation has not overcome in almost six decades since the advent of immunosuppressive drugs enabled the field to flourish.

9 May 2020

RNA interference machinery influences epithelial cell biology

Epithelial cells are held together and connected by several different types of structures that form cell-cell contacts.

9 May 2020

New compound significantly reduces multiple pathologies linked to Alzheimer's disease

When tested in brain cells and in a mouse model of Alzheimer's disease, a new compound significantly reduced the number of amyloid plaques in the brain, lessened brain inflammation and diminished other molecular markers of the disease.

8 May 2020

Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

An international team led by Emory scientists has gained insight into the pathological mechanisms behind two devastating neurodegenerative diseases.

6 May 2020

Study explores maternal infection and its role in neurodevelopmental disorders

The immune responses of a female mouse before pregnancy can predict how likely her offspring are to have behavioral deficits if the immune system is activated during pregnancy, according to researchers from the Center for Neuroscience at the University of California, Davis.

5 May 2020

Bioactive lipids are key for diagnosis and treatment of cardiac repair after heart attack

Black men and women have higher incidences than whites of developing advanced heart failure following a heart attack.

5 May 2020

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

The novel coronavirus has rapidly infected millions over the world in over 187 countries and territories, causing hundreds of thousands of deaths. One of the often-neglected and under-reported symptoms of the virus is the loss of the sense of smell or anosmia. Now, a new study out of Germany published on the preprint server medRxiv in April 2020 provides a quantified estimate of the magnitude of anosmia as a symptom of the coronavirus.

4 May 2020

Study finds Lin28 as promising therapeutic target for central nervous system injuries

Like power lines in an electrical grid, long wiry projections that grow outward from neurons - structures known as axons - form interconnected communication networks that run from the brain to all parts of the body.

2 May 2020

Researchers develop a new way to treat chronic pain

Researchers from the University of Copenhagen have developed a new way to treat chronic pain which has been tested in mice. With a compound designed and developed by the researchers themselves, they can achieve complete pain relief.

30 Apr 2020

Study explores molecular connections between genetics, gut microbiome and memory

A new study is among the first to trace the molecular connections between genetics, the gut microbiome and memory in a mouse model bred to resemble the diversity of the human population.

29 Apr 2020

CNIC researchers develop mouse model to examine the mechanical function of proteins

The Molecular Mechanics of the Cardiovascular System group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), led by Jorge Alegre Cebollada, in partnership with an international scientific team, has generated the first experimental mouse model that allows direct analysis of the mechanical function of proteins in living organisms.

28 Apr 2020

Researchers report promising new therapy for recurrent pediatric brain cancers

Two pediatric brain cancers that are challenging to treat if they recur, medulloblastoma and ependymoma, are the target of a clinical trial using a new type of therapy.

27 Apr 2020

New potential treatment candidate identified for early type 2 diabetic retinopathy

Diabetic retinopathy is one of the main vascular complications of type 2 diabetes, and the most common cause of visual deterioration in adults.

27 Apr 2020

New study indicates novel therapies for Duchenne muscular dystrophy

When an actor is unable to perform in the theatre, an understudy--ideally one with some practice in the role--can take her place on stage.

25 Apr 2020

Active ingredient from parasite larvae could help treat asthma

The larvae of the roundworm Heligmosomoides polygyrus bakeri (Hpb) need a very special environment in order to survive: They have to invade the mucosal layer of the intestine in rodents, the only place where they can then develop into adult worms capable of reproduction.

24 Apr 2020

Researchers report promising Phase 1 results for first oral polio vaccine in 50 years

Before being halted due to the COVID-19 pandemic, a relentless vaccination campaign had nearly succeeded in eradicating polio from the world.

24 Apr 2020

Study: Astrocytes regulate neuronal circuits involved in learning and memory

Researchers at Baylor College of Medicine reveal that astrocytes, the most abundant cells in the brain, play a direct role in the regulation of neuronal circuits involved in learning and memory. The findings appear in the journal Neuron.

24 Apr 2020

Combination therapy boosts the immune system's appetite for cancer

A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission, a new study led by UT Southwestern scientists suggests.

24 Apr 2020

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Overreaction is rarely useful, and in the case of the human immune system, it can be outright deadly. When the body overreacts to an infection, the result is sepsis - a life-threatening condition that frequently leads to acute organ dysfunction, including deterioration of the heart and blood vessels, which make up the cardiovascular system.

24 Apr 2020

Higher levels of specific gene can indicate better prognosis in prostate cancer

The most common form of cancer in older men is prostate cancer. In many cases the tumor grows slowly and can be treated effectively, but it is sometimes more aggressive and becomes terminal.

23 Apr 2020

Mouse Model News and Research

New discovery could end chronic rejection of transplanted organs

RNA interference machinery influences epithelial cell biology

New compound significantly reduces multiple pathologies linked to Alzheimer's disease

Scientists gain new insight into the pathological mechanisms behind two neurodegenerative diseases

Study explores maternal infection and its role in neurodevelopmental disorders

Bioactive lipids are key for diagnosis and treatment of cardiac repair after heart attack

Loss of smell may be related to neuroinvasive propensity of SARS-CoV-2

Study finds Lin28 as promising therapeutic target for central nervous system injuries

Researchers develop a new way to treat chronic pain

Study explores molecular connections between genetics, gut microbiome and memory

CNIC researchers develop mouse model to examine the mechanical function of proteins

Researchers report promising new therapy for recurrent pediatric brain cancers

New potential treatment candidate identified for early type 2 diabetic retinopathy

New study indicates novel therapies for Duchenne muscular dystrophy

Active ingredient from parasite larvae could help treat asthma

Researchers report promising Phase 1 results for first oral polio vaccine in 50 years

Study: Astrocytes regulate neuronal circuits involved in learning and memory

Combination therapy boosts the immune system's appetite for cancer

Study: JNK and BNP activity can reverse cardiovascular damage, reduce risk of death from sepsis

Higher levels of specific gene can indicate better prognosis in prostate cancer

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