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Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Over the past months, many potential antivirals against SARS-CoV-2 have been identified as deserving further development to target several viral proteins. A new study deals with one such molecule, the viral main protease (Mpro) inhibitor GC-376, and describes its efficacy in inhibiting virus-host interaction.

2 Feb 2021

Ivermectin may not be the ‘silver bullet’ antiviral against COVID-19

A team of researchers based in Peru and the U.S. recently examined the role of the anti-parasitic drug ivermectin in treating COVID-19.

1 Feb 2021

Harnessing the natural potential of venom with the VOYAGER pipette

Venom, found in numerous species of reptiles, can cause intense pain and even paralysis but, paradoxically, can be used as medication to actually reduce pain.

From INTEGRA Biosciences 1 Feb 2021

Early-life-trauma could affect trajectory of multiple sclerosis development and treatment

Childhood trauma could affect the trajectory of multiple sclerosis development and response to treatment in adulthood, a new study in mice found.

29 Jan 2021

Researchers identify new strategy to protect offspring from prenatal stress

New research from the University of Iowa and University Hospitals Cleveland Medical Center demonstrates that offspring can be protected from the effects of prenatal stress by administering a neuroprotective compound during pregnancy.

29 Jan 2021

Study: Targeting glycoprotein could improve response to cancer immunotherapy

It was an unexpected discovery that started with an analysis of more than 1,000 genes. The question: why game-changing cancer immunotherapy treatments work for only a fraction of patients.

28 Jan 2021

Researchers design an on-chip printed 'electronic nose'

Skoltech researchers and their colleagues from Russia and Germany have designed an on-chip printed 'electronic nose' that serves as a proof of concept for low-cost and sensitive devices to be used in portable electronics and healthcare.

28 Jan 2021

Chinese spice provides insight into how human brains detect and perceive touch

New insight into how human brains detect and perceive different types of touch, such as fluttery vibrations and steady pressures, has been revealed by UCL scientists with the help of the ancient Chinese cooking ingredient, Szechuan pepper.

28 Jan 2021

Substances in tick saliva activate immune response-suppressing proteins in cattle

A tick saliva study reveals immune responses that could lead to better protection for cattle.

28 Jan 2021

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

The BBVA Foundation Frontiers of Knowledge Award in Biology and Biomedicine has gone in this thirteenth edition to David Julius, from the University of California, San Francisco, and Ardem Patapoutian, from the Scripps Institute, La Jolla (United States), "for identifying the receptors that enable us to sense temperature, pain and pressure."

28 Jan 2021

Plants depend on LEAFY protein that enables cells to change their fate

Cells don't express all the genes they contain all the time. The portion of our genome that encodes eye color, for example, doesn't need to be turned on in liver cells. In plants, genes encoding the structure of a flower can be turned off in cells that will form a leaf.

28 Jan 2021

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

It was the end of April — just as the U.S. confirmed its millionth covid-19 case and 50,000 deaths — when White House adviser Dr. Anthony Fauci announced "highly significant" news about a drug called remdesivir.

27 Jan 2021

New compound could lead to a new class of diabetes drugs

Research led by The Ohio State University Wexner Medical Center and College of Medicine identified a new compound that might serve as a basis for developing a new class of drugs for diabetes.

27 Jan 2021

New compound may slow aging and age-related diseases

A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases.

27 Jan 2021

Medicinal cannabis improves outcomes in Parkinson's patients

With medicinal cannabis now legalized in many parts of the world, there is growing interest in its use to alleviate symptoms of many illnesses including Parkinson's disease (PD).

27 Jan 2021

World's first fully reversible manipulation of the circadian clock

The Nagoya University Institute of Transformative Bio-Molecules research team of Designated Associate Professor Tsuyoshi Hirota, Postdoctoral Fellow Simon Miller, Professor Kenichiro Itami and graduate student Tsuyoshi Oshima (Research Fellowship for Young Scientists, JSPS), in collaboration with the group of Professor Ben Feringa and Postdoctoral Fellow Dušan Kolarski of Groningen University in the Netherlands, have achieved a world first: fully reversible manipulation of the period of the circadian clock using light, by exchanging part of a compound with a light-activated switch.

25 Jan 2021

Study: Understanding nutrient accumulation within cycads is essential to effective horticultural management

Collective research to date regarding nutrients found in the leaves of contemporary cycad species has been inconsistent as far as data collection and narrow in scope, according to a University of Guam-led literature review published on Nov. 19 in Horticulturae journal.

24 Jan 2021

UC researchers test new combination therapy for head and neck cancer in animal models

Head and neck cancer is the sixth most common cancer worldwide, and while effective treatments exist, sadly, the cancer often returns.

22 Jan 2021

New SERS-based sensor can detect influenza A viral pathogens with high reproducibility

Respiratory diseases like influenza can spread rapidly and escalate to global health crises. Thus, to control them, simple yet sensitive detection techniques are needed. Surface-enhanced Raman scattering (SERS) is a potential candidate but currently lacks reproducibility.

22 Jan 2021

Scientists identify a molecular mechanism that protects the fetus from maternal infection

Researchers at Duke and Mt. Sinai have identified a molecular mechanism that prevents a viral infection during a mother's pregnancy from harming her unborn baby.

21 Jan 2021

Compound News and Research

Antiviral compound GC-376 shows efficacy against SARS-CoV-2 in vivo

Ivermectin may not be the ‘silver bullet’ antiviral against COVID-19

Harnessing the natural potential of venom with the VOYAGER pipette

Early-life-trauma could affect trajectory of multiple sclerosis development and treatment

Researchers identify new strategy to protect offspring from prenatal stress

Study: Targeting glycoprotein could improve response to cancer immunotherapy

Researchers design an on-chip printed 'electronic nose'

Chinese spice provides insight into how human brains detect and perceive touch

Substances in tick saliva activate immune response-suppressing proteins in cattle

David Julius and Ardem Patapoutian receive Frontiers of Knowledge Award in Biology and Biomedicine

Plants depend on LEAFY protein that enables cells to change their fate

Remdesivir, given to half of hospitalized covid patients in U.S., is big win for Gilead — boosted by taxpayers

New compound could lead to a new class of diabetes drugs

New compound may slow aging and age-related diseases

Medicinal cannabis improves outcomes in Parkinson's patients

World's first fully reversible manipulation of the circadian clock

Study: Understanding nutrient accumulation within cycads is essential to effective horticultural management

UC researchers test new combination therapy for head and neck cancer in animal models

New SERS-based sensor can detect influenza A viral pathogens with high reproducibility

Scientists identify a molecular mechanism that protects the fetus from maternal infection

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

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