Mouse Model News and Research

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Alternative model addresses the shortcomings of neutrophil-depletion model

s the COVID-19 pandemic continues to spread, researchers are turning their attention to the virus' biology, mechanism of action, and possible treatments. One of the targets are a group of immune cells called "neutrophils", which have been reported to infiltrate the respiratory tract of patients who have died from COVID-19.

2 Jun 2020

A moving target identified in small cell lung tumors

Lung cancers account for approximately 25 percent of all cancer deaths. Even among those who do not smoke, 1 in 15 men and 1 in 17 women are expected to develop lung cancer in their lifetime, according to the American Cancer Society.

1 Jun 2020

Study provides groundwork for restoring nerve-muscle connection in ALS

Patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, lose muscle control as nerve cells or neurons in the brain and spinal cord degenerate and can no longer send signals to muscles.

28 May 2020

Inhibiting tumor signals can suppress the spread of cancer

For most people who die of cancer, the spread of the initial tumor is to blame. "Metastasis is what kills most cancer patients," says Serge Fuchs, a professor in Penn's School of Veterinary Medicine.

28 May 2020

Transgenic mouse model of HLH may play key role in saving lives during COVID-19

A transgenic mouse developed at Cincinnati Children's to model the deadly childhood immune disease HLH (hemophagocytic lymphohistiocytosis) may play a key role in saving lives during the COVID-19 virus pandemic.

28 May 2020

Mouse model mimics clinical course and pathology observed in COVID-19 patients

A mouse model of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reproduces features observed in human patients, researchers report May 26 in the journal Cell Host & Microbe.

27 May 2020

Novel immunotherapy targeting myeloid immune cells reduces tumor growth

Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions.

27 May 2020

New strategy identified to address the underlying cause of LAD1 patients' symptoms

Owing to a rare genetic mutation, individuals with leukocyte adhesion deficiency type 1 (LAD1) experience a suite of symptoms that trace back to an immune system dysfunction.

27 May 2020

New technique offers high-resolution 3D view inside tumors

Malignant tumors consume nutrients and oxygen faster than healthy cells. To do so, they recruit blood vessels in their environment. Depending on tumor type and genetic profile, there are differences on how tumors look internally.

26 May 2020

Advanced MRI picks out even small tumors from normal tissue

Researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue.

26 May 2020

Doctoral candidate receives NIH fellowship to study how adenovirus affects heart function

A dose of adenovirus hits most people like a common cold - a cough, a fever, maybe a sore throat. But for an unfortunate few, the usually benign bug hacks the heart's cellular electrical communication system and sometimes proves fatal.

20 May 2020

Gene mutation linked to MEF2C haploinsufficiency syndrome

A collaboration between scientists at the Medical University of South Carolina and clinicians at the Greenwood Genetic Center has yielded new findings about how a particular gene might regulate brain development.

19 May 2020

Study shows human monoclonal antibodies can effectively neutralize SARS-CoV-2

US researchers have published a proof of concept on the efficacy of human monoclonal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in laboratory conditions, as well as their pioneering use in a mouse model. The study is available on the preprint server bioRxiv*.

17 May 2020

Biologic drug can help treat contact dermatitis

APOSEC it is a biologic wound-healing agent developed by thoracic surgeon Hendrik Jan Ankersmit from MedUni Vienna.

15 May 2020

Mouse model helps track organism’s development from embryonic stage to adulthood

Scientists at the Stem Cell Research program at Boston Children's Hospital and Dana-Farber Cancer Institute/Harvard Medical School have devised a mouse model that lets researchers track every cell in the body, from the embryonic stage until adulthood.

15 May 2020

Activity of malaria-causing parasite is driven by the parasite's own inherent clocks

The activity of the parasite that causes malaria is driven by the parasite's own inherent clock, new research led by UT Southwestern scientists suggests. The findings, published this week in Science, could lead to new ways to fight this pervasive and deadly disease.

15 May 2020

New imaging device can help detect early biomarker of Alzheimer’s disease

Biomedical engineers at Duke University have devised a new imaging device capable of measuring both the thickness and texture of the various layers of the retina at the back of the eye.

15 May 2020

Reductive stress is intolerable, can induce heart failure

Many heart diseases are linked to oxidative stress, an overabundance of reactive oxygen species. The body reacts to reduce oxidative stress -- where the redox teeter-totter has gone too far up -- through production of endogenous antioxidants that reduce the reactive oxygen species.

14 May 2020

A promising treatment for chronic inflammatory liver disease

Primary sclerosing cholangitis (PSC) is a rare, chronic, inflammatory disease of the bile ducts and is difficult to treat.

14 May 2020

Researchers identify CoV Mac1 proteins as a potential SARS-CoV-2 drug target

A recent study by researchers at the University of Kansas and published on the preprint server bioRxiv* reveals that Mac1 protein implicated in the infection process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a strikingly similar structure and activity in all coronaviruses – suggesting that possible future treatments targeting this protein may exert broad antiviral activity.

13 May 2020