Clinical Trial News and Research

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New drug shows strong activity against brain metastases in HER2-positive breast cancer

A drug that delivers chemotherapy directly to tumors has shown impressive activity against some of the hardest-to-reach cancer cells: those that have spread to the brain in patients with advanced HER2-positive breast cancer.

13 Sep 2024

Breakthrough study sheds light on mechanisms behind the spread of gastric cancer to the peritoneum

Gastric cancer remains a formidable adversary, ranking as the fifth most common cancer and the third-leading cause of cancer-related deaths worldwide, with over 1,000,000 new cases and close to 770,000 deaths each year.

13 Sep 2024

Trial finds no benefit of adding nivolumab to tivozanib for advanced kidney cancer

In an international multicenter randomized phase 3 clinical trial led by Dana-Farber Cancer Institute, researchers tested the addition of the immune checkpoint inhibitor (ICI) nivolumab to treatment with tivozanib for patients with advanced clear cell renal cell carcinoma, a form of kidney cancer.

13 Sep 2024

Cannabidiol shows promise in treating cognitive disorders

Research reviews the therapeutic potential of cannabidiol (CBD) in treating cognitive impairments, highlighting positive effects in some trials while emphasizing the need for more comprehensive studies.

12 Sep 2024

New vaccine candidate shows promise for protecting against Lassa fever

Researchers from Thomas Jefferson University and the University of Maryland Baltimore, in collaboration with the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) and the Geneva Foundation, have developed a promising new vaccine candidate that protects against Lassa fever.

12 Sep 2024

Duffy-null phenotype may lead to unfair exclusion from cancer drug trials

Many clinical trials of new cancer drugs may be inappropriately excluding some people with "Duffy-null phenotype," a trait found predominantly in people of African or Middle Eastern descent, researchers at Dana-Farber Cancer Institute and Queen Mary University of London report in a new study.

12 Sep 2024

Laughter exercise could be an initial treatment for relieving dry eye disease symptoms

Laughter may be as effective as eye drops in improving symptoms of dry eye disease, finds a clinical trial from China published by The BMJ today.

11 Sep 2024

New ultrasound technology provides effective treatment for urinary stones

A noninvasive ultrasound technology called Break Wave™ lithotripsy (BWL) offers a safe and effective new option for treatment of urinary stones, reports a clinical trial in the October issue of The Journal of Urology, an Official Journal of the American Urological Association (AUA).

11 Sep 2024

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

The c-Met-directed antibody-drug conjugate telisotuzumab vedotin demonstrated durable responses and an acceptable safety profile in patients of Asian race with c-Met protein-overexpressing, epidermal growth factor receptor (EGFR) wildtype (WT), locally advanced/metastatic nonsquamous non-small cell lung cancer (NSCLC), according to research presented today at the International Association for the Study of Lung Cancer's 2024 World Conference on Lung Cancer.

11 Sep 2024

Zongertinib shows promising efficacy in HER2 mutation-positive NSCLC

The HER2-specific tyrosine kinase inhibitor zongertinib was well tolerated and demonstrated promising efficacy in patients with HER2 mutation-positive non-small cell lung cancer, meeting the primary endpoint of the Beamion LUNG-1 Phase Ib Cohort 1 study, according to research presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer.

11 Sep 2024

Study shows delayed feedback enhances learning in traumatic brain injury

Kessler Foundation researchers have published a novel study exploring the effects of delayed feedback on learning in individuals with moderate-to-severe traumatic brain injury (TBI).

11 Sep 2024

Taletrectinib shows high response rates and safety in ROS1+ lung cancer patients

The ROS1 tyrosine kinase inhibitor (TKI) taletrectinib demonstrated high overall and intracranial responses, and a favorable safety profile with low incidence of neurologic adverse events in TKI-naive and TKI-pretreated patients with ROS1+ non-small cell lung cancer (NSCLC).

11 Sep 2024

Pre-surgery chemotherapy shows promise for preserving vital organs in nasal and sinus cancer

Results from a clinical trial by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) show a striking improvement for patients who received chemotherapy before surgery to remove advanced squamous cell-type cancer of the nose or sinus.

11 Sep 2024

Promising new approach to combat HIV

Researchers at Université de Montréal's affiliated hospital research center, the CRCHUM, say the discovery could help lessen and even eliminate viral loads in people undergoing antiretroviral therapy.

11 Sep 2024

Air pollution raises lung cancer risk for women

Recent air pollution exposure in the form of particles smaller than 2.5 micrometers (PM2.5) exposure may significantly impact lung cancer in women who have never smoked, with notable differences in stage IV diagnoses among EGFR+ patients, according to research presented today at the International Association for the Study of Lung Cancer (IASLC) 2024 World Conference on Lung Cancer.

11 Sep 2024

Sulthiame shows promise in reducing obstructive sleep apnea symptoms

Patients taking sulthiame, a drug currently in use for epilepsy, experienced a reduction in their symptoms of obstructive sleep apnoea (OSA), according to results of a clinical trial presented at the European Respiratory Society (ERS) Congress in Vienna, Austria.

10 Sep 2024

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

A study presented today at the International Association for the Study of Lung Cancer 2024 World Conference on Lung Cancer demonstrated a promising pathway toward developing predictive biomarkers for immune checkpoint inhibitors.

9 Sep 2024

Ifinatamab deruxtecan shows promising results in advanced small cell lung cancer

The antibody–drug conjugate ifinatamab deruxtecan (I-DXd) showed clinically meaningful responses in pretreated patients with extensive-stage small cell lung cancer (ES-SCLC), according to an interim analysis of the Phase 2 IDeate-Lung01 study.

9 Sep 2024

Study shows cognitive behavioral therapy can lead to brain changes in depression patients

Cognitive behavioral therapy, one of the most common treatments for depression, can teach skills for coping with everyday troubles, reinforce healthy behaviors and counter negative thoughts. But can altering thoughts and behaviors lead to lasting changes in the brain?

6 Sep 2024

Yoga and stretching offer relief for urinary incontinence in older women

Older women struggling with urinary incontinence can benefit from regular, low-impact exercise, with yoga as well as stretching and strengthening showing benefits in a new study published Aug. 27 in Annals of Internal Medicine.

6 Sep 2024

Clinical Trial News and Research

New drug shows strong activity against brain metastases in HER2-positive breast cancer

Breakthrough study sheds light on mechanisms behind the spread of gastric cancer to the peritoneum

Trial finds no benefit of adding nivolumab to tivozanib for advanced kidney cancer

Cannabidiol shows promise in treating cognitive disorders

New vaccine candidate shows promise for protecting against Lassa fever

Duffy-null phenotype may lead to unfair exclusion from cancer drug trials

Laughter exercise could be an initial treatment for relieving dry eye disease symptoms

New ultrasound technology provides effective treatment for urinary stones

Telisotuzumab vedotin shows promising results in asian patients with c-Met overexpressing NSCLC

Zongertinib shows promising efficacy in HER2 mutation-positive NSCLC

Study shows delayed feedback enhances learning in traumatic brain injury

Taletrectinib shows high response rates and safety in ROS1+ lung cancer patients

Pre-surgery chemotherapy shows promise for preserving vital organs in nasal and sinus cancer

Promising new approach to combat HIV

Air pollution raises lung cancer risk for women

Sulthiame shows promise in reducing obstructive sleep apnea symptoms

Promising pathway for predictive biomarkers in lung cancer immunotherapy revealed

Ifinatamab deruxtecan shows promising results in advanced small cell lung cancer

Study shows cognitive behavioral therapy can lead to brain changes in depression patients

Yoga and stretching offer relief for urinary incontinence in older women

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