Clinical Trial News and Research

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Long-term, 30-year CVD risk may help inform therapy for stage 1 hypertension

A comparison of two risk prediction tools used to calculate an individual's risk of developing cardiovascular disease (CVD) suggests that the long-term, 30-year risk should be considered in addition to the short-term, 10-year risk to help inform when to begin medication therapy for stage 1 hypertension, or high blood pressure, according to new research published today in Hypertension, an American Heart Association journal.

15 Jul 2024

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Tirzepatide, a novel twincretin drug, significantly improves weight loss and glycemic control in obese and type 2 diabetes patients, outperforming traditional treatments in clinical trials.

15 Jul 2024

Testing the effectiveness of youth activism as a mental health intervention

Three hundred Black and Latinx teens in Chicago will be recruited to participate in the first clinical trial to measure the potential health benefits of youth-driven racial justice activism. The five-year study, funded by a $3.8 million grant from the National Institute on Minority Health and Health Disparities, will assess whether activism can lower depression symptoms in minoritized teens, as well as alter physiological factors known to be increased with exposure to racism, such as blood pressure and markers of stress and inflammation in the blood.

13 Jul 2024

New option emerges for managing stress urinary incontinence

An investigational medication designated TAS-303 shows efficacy and safety in treatment of women with stress urinary incontinence (SUI), reports a placebo-controlled clinical trial in the August issue of The Journal of Urology®, an Official Journal of the American Urological Association (AUA). The journal is published in the Lippincott portfolio by Wolters Kluwer.

12 Jul 2024

Cellular immunotherapy offers hope for solid tumors

Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic solid tumors. In the trial, researchers from the National Institutes of Health (NIH) genetically engineered normal white blood cells, known as lymphocytes, from each patient to produce receptors that recognize and attack their specific cancer cells.

12 Jul 2024

New tech shows promise for mental wellbeing

One of the intriguing abilities of the human mind is daydreaming, where the mind wanders off into spontaneous thoughts, fantasies and scenarios, often without conscious effort, allowing creativity and reflection to flow freely.

12 Jul 2024

Researchers discover a new mechanism of resistance to KRAS inhibitors in pancreas cancer

Mutations in the KRAS gene are the primary driver of pancreatic cancer. A new class of drugs known as KRAS inhibitors is showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment.

11 Jul 2024

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

CAR-T cell therapy, which targets a specific protein on the surface of cancer cells, causes tumors to shrink or disappear in about half of patients with large B-cell lymphoma who haven't experienced improvement with chemotherapy treatments.

11 Jul 2024

Novel model could predict cognitive decline in patients with mild cognitive impairment due to Alzheimer's

Amsterdam UMC's Alzheimer Centre has developed a prediction model that can predict cognitive decline in patients with mild cognitive impairment or mild dementia due to Alzheimer's disease.

11 Jul 2024

Innovative aiTBS therapy shortens treatment duration for bipolar disorder

A potential new treatment for bipolar disorder (BP) that significantly shortens treatment time has emerged, following a randomized clinical trial using accelerated intermittent theta burst stimulation (aiTBS).

11 Jul 2024

LSVT LOUD outperforms NHS speech and language therapy for people with Parkinson's disease

An intensive voice treatment developed in the USA and known as the Lee Silverman voice treatment (LSVT LOUD) is more effective than conventional NHS speech and language therapy or no therapy for people with Parkinson's disease, finds a trial published in The BMJ today.

11 Jul 2024

New gene editing technique offers hope for millions

A team led by Mass Eye and Ear researchers has demonstrated for the first time a successful restoration of hearing through a novel, in vivo genome editing approach in an adult mouse model with a form of inherited deafness caused by mutations in microRNA.

11 Jul 2024

Chronic exposure to air pollutants may increase lupus risk, research shows

New research published in Arthritis & Rheumatology indicates that chronic exposure to air pollutants may increase the risk of developing lupus, an autoimmune disease that affects multiple organs.

10 Jul 2024

Advocate Health selected for CMS GUIDE Model aimed at advancing dementia care

Advocate Health has been selected by the Centers for Medicare and Medicaid Services (CMS) to participate in the Guiding an Improved Dementia Experience (GUIDE) Model, aimed to support advanced dementia patients and their caregivers in bridging the gaps associated with inequalities in dementia care.

10 Jul 2024

Clinical Trial News and Research

Long-term, 30-year CVD risk may help inform therapy for stage 1 hypertension

Twincretin drug Tirzepatide shows unmatched efficacy in weight loss and diabetes management

Testing the effectiveness of youth activism as a mental health intervention

New option emerges for managing stress urinary incontinence

Cellular immunotherapy offers hope for solid tumors

New tech shows promise for mental wellbeing

Researchers discover a new mechanism of resistance to KRAS inhibitors in pancreas cancer

CD22-targeted CAR-T therapy shows promising results in relapsed large B-cell lymphoma

Novel model could predict cognitive decline in patients with mild cognitive impairment due to Alzheimer's

Innovative aiTBS therapy shortens treatment duration for bipolar disorder

LSVT LOUD outperforms NHS speech and language therapy for people with Parkinson's disease

New gene editing technique offers hope for millions

Chronic exposure to air pollutants may increase lupus risk, research shows

Advocate Health selected for CMS GUIDE Model aimed at advancing dementia care

High-intensity interval exercise improves brain function in older adults

UCLA research highlights delayed Huntington's disease diagnosis for Black patients

Mayo Clinic makes medical history with total larynx transplant for cancer patient

Understanding patient distress in sickle cell disease

From Dr. Oz to heart valves: A tiny device charted a contentious path through the FDA

Combined use of popular diabetes drugs likely to offer additional protection against heart and kidney disease

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