Endocrine News and Research

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Glucagon loses its ability to help obese people, but continues to suppress hunger pangs

Glucagon, a hormone involved in regulating appetite, loses its ability to help obese people feel full after a meal, but it continues to suppress hunger pangs in people with type 1 diabetes, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

21 Aug 2013

Study: Pregnant women with gestational diabetes lose over an hour of sleep each night

Women diagnosed with gestational diabetes are nearly seven times more likely to have obstructive sleep apnea than other pregnant women, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

21 Aug 2013

3-D structure of proteins show flame retardants can mimic estrogen hormones

By determining the three-dimensional structure of proteins at the atomic level, researchers at the National Institutes of Health have discovered how some commonly used flame retardants, called brominated flame retardants (BFRs), can mimic estrogen hormones and possibly disrupt the body's endocrine system. BFRs are chemicals added or applied to materials to slow or prevent the start or growth of fire.

20 Aug 2013

Endocrine Society, global partners to host international meeting for promoting endocrinology in India

Chevy Chase, MD-A new major collaborative partnership among international hormone health organizations will help promote endocrinology on the Indian sub-continent. The Endocrine Society has joined the Endocrine Society of India (ESI), the Society for Endocrinology in the United Kingdom and International Society of Endocrinology (ISE) to host the inaugural International Clinical Update program in Endocrinology (ICUE), February 1-2 in Hyderabad, India.

19 Aug 2013

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

The human body is a complicated system of blood vessels, nerves, organs, tissue and cells each with a specific job to do. When all are working together, it's a symphony of form and function as each instrument plays its intended roles.

17 Aug 2013

Managing insulin levels through meal timing boosts ovulation in women with PCOS

Polycystic Ovarian Syndrome (PCOS), a common disorder that impairs fertility by impacting menstruation, ovulation, hormones, and more, is closely related to insulin levels. Women with the disorder are typically "insulin resistant" - their bodies produce an overabundance of insulin to deliver glucose from the blood into the muscles.

14 Aug 2013

Study reveals epigenetic mechanisms contribute to chronic disease susceptibility prior to birth

If you think stress is killing you, you may be right, but what you don't know is that stress might have harmed your health even before you were born. In a new report appearing in the August 2013 issue of The FASEB Journal, Harvard researchers find that epigenetic disruptions, which are associated with chronic disease later in life, are already common at birth.

2 Aug 2013

Deletion of a protein improves ability to fight bacteria in mice with CGD

Deletion of a protein in white blood cells improves their ability to fight the bacteria staphylococcus aureus and possibly other infections in mice with chronic granulomatous disease (CGD), according to a National Institutes of Health study. CGD, a genetic disorder also found in people, is marked by recurrent, life-threatening infections. The study's findings appear online in The Journal of Clinical Investigation.

2 Aug 2013

Study proposes novel approach for understanding how genome affects biology of the human body

Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient’s genetic profile –also known as personalized medicine – we need to know how this genetic variant affects health.

1 Aug 2013

Boehringer Ingelheim, Lilly initiate linagliptin clinical trial in adults with Type 2 Diabetes

Boehringer Ingelheim and Eli Lilly and Company today announced enrollment of the first patient into a cardiovascular and renal outcomes trial for linagliptin (Trajenta).

1 Aug 2013

Montreal scientists develop novel approach for scanning entire genome

Recent technological developments in genomics have revealed a large number of genetic influences on common complex diseases, such as diabetes, asthma, cancer or schizophrenia. However, discovering a genetic variant predisposing to a disease is only a first step. To apply this knowledge towards prevention or cure, including tailoring treatment to the patient's genetic profile -also known as personalized medicine - we need to know how this genetic variant affects health.

1 Aug 2013

Reinnervate's Alvetex Scaffold system chosen for 3D osteocytic cell culture experiments in microgravity

Market leading 3D cell culture company Reinnervate Ltd today announced that its Alvetex®Scaffold system has been chosen by a group at Massachusetts General Hospital for the first ever 3D osteocytic cell culture experiments in microgravity.

31 Jul 2013

Male and female rats show different patterns of kidney gene expression throughout their lives

Male and female rats show different patterns of kidney gene expression throughout their lives, a study in the open access journal Biology of Sex Differences reveals. The finding could help explain some of the gender differences observed in human renal disease, and lead to improved biomarkers of kidney function.

31 Jul 2013

Perfluoroalkyl substances are crossing blood brain barrier of polar bears

PerFluoroAlkyl Substances (PFASs) and precursor compounds have been used in a wide variety of commercial and industrial products over the past six decades. Applications include water and oil repellent coatings, e.g. for textiles, paper products, carpets and food packaging, pharmaceuticals and surfactants in cleaning products and fire-fighting foams.

25 Jul 2013

Melatonin pre-treatment greatly increases cell survival, say researchers

When melatonin, a hormone secreted by the pineal gland, was used as a pre-treatment for mesenchymal stem cells prior to their transplantation into the brains of laboratory animals to repair damage from stroke, researchers in China found that the stem cells survived longer after transplantation. Previous studies had shown that 80 percent of transplanted MSCs died within 72 hours of transplantation.

23 Jul 2013

Jersey Shore to present free educational conference focusing on thyroid cancer patients, survivors

On Friday, August 2, 2013, Jersey Shore, in partnership with Meridian Cancer Care and the Light of Life Foundation, will present a free educational conference featuring Meridian Health specialists.

22 Jul 2013

Metabolomics tools predict who can benefit from treatment with certain antidepressants

Duke Medicine researchers have identified biochemical changes in people taking antidepressants - but only in those whose depression improves. These changes occur in a neurotransmitter pathway that is connected to the pineal gland, the part of the endocrine system that controls the sleep cycle, suggesting an added link between sleep, depression and treatment outcomes.

19 Jul 2013

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

Scientists at the University of Massachusetts Medical School are the first to establish that a naturally occurring X chromosome "off switch" can be rerouted to neutralize the extra chromosome responsible for trisomy 21, also known as Down syndrome, a genetic disorder characterized by cognitive impairment.

18 Jul 2013

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

The study is reported on July 17, 2013, in an advance online edition of the journal Nature, alongside a British laboratory's structural study of another member of the same class of receptors-known as "class B" G protein-coupled receptors (GPCRs).

18 Jul 2013

Seafood provides essential nutrients but consumers still keep watchful eye on safety

Seafood continues to be a proven strong nutrient-rich food providing essential vitamins, minerals and omega-3 fatty acids, but consumers and some toxicologists still keep a watchful eye on safety, according to a July 16 panel discussion at the 2013 Institute of Food Technologists (IFT) Annual Meeting & Food Expo- held at McCormick Place.

18 Jul 2013

Endocrine News and Research

Glucagon loses its ability to help obese people, but continues to suppress hunger pangs

Study: Pregnant women with gestational diabetes lose over an hour of sleep each night

3-D structure of proteins show flame retardants can mimic estrogen hormones

Endocrine Society, global partners to host international meeting for promoting endocrinology in India

Interactions between sympathetic neurons and pancreatic cells have implications for organ development

Managing insulin levels through meal timing boosts ovulation in women with PCOS

Study reveals epigenetic mechanisms contribute to chronic disease susceptibility prior to birth

Deletion of a protein improves ability to fight bacteria in mice with CGD

Study proposes novel approach for understanding how genome affects biology of the human body

Boehringer Ingelheim, Lilly initiate linagliptin clinical trial in adults with Type 2 Diabetes

Montreal scientists develop novel approach for scanning entire genome

Reinnervate's Alvetex Scaffold system chosen for 3D osteocytic cell culture experiments in microgravity

Male and female rats show different patterns of kidney gene expression throughout their lives

Perfluoroalkyl substances are crossing blood brain barrier of polar bears

Melatonin pre-treatment greatly increases cell survival, say researchers

Jersey Shore to present free educational conference focusing on thyroid cancer patients, survivors

Metabolomics tools predict who can benefit from treatment with certain antidepressants

Discovery provides evidence that genetic defect responsible for Down syndrome can be suppressed

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

Seafood provides essential nutrients but consumers still keep watchful eye on safety

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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