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Common protein in skin can directly activate itch-associated neurons

A commonly expressed protein in skin - periostin - can directly activate itch-associated neurons in the skin, according to new research from North Carolina State University.

7 Apr 2020

Compound in fruit peels can reduce and reverse neuronal damage in multiple sclerosis

Multiple sclerosis, characterized by increasing muscle weakness and paralysis, has a number of treatments that help stall progression of the disease when used early on in the disease.

6 Apr 2020

Research suggests an avenue to treat, prevent genetic disorders in the womb

New research led by hearing scientists at Oregon Health & Science University suggests an avenue to treat and prevent intractable genetic disorders before birth.

6 Apr 2020

Novel immunotherapy eradicates solid tumors in mice without adverse side effects

Scientists have developed a new immunotherapy that eradicates solid tumors in mice without adverse side effects, according to a new study published today in eLife.

31 Mar 2020

UDCA treatment affects C. diff life cycle, reduces inflammatory response in mice

Researchers from North Carolina State University have found that a commonly used drug made from secondary bile acids can affect the life cycle of Clostridioides difficile (C. diff) in vitro and reduce the inflammatory response to C. diff in mice.

30 Mar 2020

Paternal alcohol consumption before conception could affect child development

Scientists at the University of California, Riverside, have explored the relationship between parental alcohol consumption -- before conception in the case of fathers and during pregnancy in the case of mothers -- and offspring development.

30 Mar 2020

New drug shows promise to reverse treatment resistance in advanced multiple myeloma

Researchers at the VU University Medical Center in the Netherlands have tested a new drug in patient samples and mice with multiple myeloma and discovered that it was effective even in advanced disease - a point when many patients currently run out of options.

27 Mar 2020

Study contradicts theory that daily aspirin prevents dementia symptoms

Scientists have disproven the theory that taking a low dose of daily aspirin reduces cognitive symptoms of dementia.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Study identifies brake on immune activity raising new possibilities for anticancer therapy

The immune system is like a carefully regulated machine, complete with its own built-in "brakes" that prevent it from overreacting and causing excess inflammation in otherwise healthy tissues.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Kidney stone disease has a high prevalence worldwide, ranging up to 13% in North America, 9% in Europe, and 5% in Asia. They are painful for patients, often lead to surgery, and impart a significant economic impact.

23 Mar 2020

Melinjo seed extract may improve obesity and diabetes

In Southeast Asia, the fruit, flowers, and leaves of Indonesia's "Melinjo" tree are traditional foods.

23 Mar 2020

Scientists identify new role of important factor in early embryonic development

In collaboration with Stanford University, a working group from MedUni Vienna’s Division of Cell and Developmental Biology, led by Mark Wossidlo, has identified the role of a factor involved in early embryonic development.

20 Mar 2020

Diet affects sperm and the health of offspring

A new study published in the journal Molecular Cell, in March 2020, reports that parental diet is a crucial factor in the future metabolic health of the offspring.

19 Mar 2020

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

When parents eat low-protein or high-fat diets it can lead to metabolic disorders in their adult offspring. Now, an international team led by researchers at the RIKEN Cluster for Pioneering Research have identified a key player and the molecular events underlying this phenomenon in mice.

19 Mar 2020

Using 'organs-on-a-chip' to study chronic inflammatory diseases

MIT biological engineers have created a multitissue model that lets them study the relationships between different organs and the immune system, on a specialized microfluidic platform seeded with human cells.

18 Mar 2020

Engineered botox more effective

A new study reports on an engineered botulinum neurotoxin (botox) that is more effective as well as safer to use in various medical procedures. The study was published in March 2020 in the open-access journal PLOS Biology.

17 Mar 2020

'Natural killer' cells could help stop progression of Parkinson's disease

Researchers at the University of Georgia's Regenerative Bioscience Center and their colleagues have found that "natural killer" white blood cells could guard against the cascade of cellular changes that lead to Parkinson's disease and help stop its progression.

16 Mar 2020

Scientists find new way to amplify miRNA in live tumor cells for bioimaging

A good indicator of dysregulation in live cells is a change in their RNA expression. MicroRNA (miRNA), a special type of RNA, is considered a biomarker for carcinogenic cells.

16 Mar 2020

Mouse Model News and Research

Common protein in skin can directly activate itch-associated neurons

Compound in fruit peels can reduce and reverse neuronal damage in multiple sclerosis

Research suggests an avenue to treat, prevent genetic disorders in the womb

Novel immunotherapy eradicates solid tumors in mice without adverse side effects

UDCA treatment affects C. diff life cycle, reduces inflammatory response in mice

Paternal alcohol consumption before conception could affect child development

New drug shows promise to reverse treatment resistance in advanced multiple myeloma

Study contradicts theory that daily aspirin prevents dementia symptoms

Cancer could potentially be treated with new immunotherapy approach, say researchers

Study identifies brake on immune activity raising new possibilities for anticancer therapy

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Fatty acid-binding protein 4 plays an important role in kidney stone formation

Melinjo seed extract may improve obesity and diabetes

Scientists identify new role of important factor in early embryonic development

Diet affects sperm and the health of offspring

Researchers uncover molecular events underlying paternal diet-induced metabolic disorders in children

Using 'organs-on-a-chip' to study chronic inflammatory diseases

Engineered botox more effective

'Natural killer' cells could help stop progression of Parkinson's disease

Scientists find new way to amplify miRNA in live tumor cells for bioimaging

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