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Breakthrough discovery could lead to new treatments for brain metastases

When cancer that starts in the body metastasizes to the brain, it is almost always lethal, in part because so few treatment options exist. Now a new study by Wistar scientists published in Nature Communications shows that a type of brain cell called astrocytes plays an important role in promoting brain metastasis by recruiting a specific subpopulation of immune cells.

24 Jun 2023

Study reveals neural circuits underlying adolescent stress-induced postpartum social behavior

Stress during adolescence can cause postpartum behavioral changes in women and other mammals, including depression and changes in social behavior after the birth of a child.

23 Jun 2023

World's largest gathering of NF community convenes in Arizona to advance research and care

From June 21 through June 27, the largest gathering of NF researchers, clinicians, and patients in the world will take place at the Fairmont Scottsdale Princess in Scottsdale, Arizona.

22 Jun 2023

Alzheimer's disease may begin during embryogenesis, stem cell study suggests

Alzheimer's disease (AD) mainly affects the older population. Recent research found early disease signs in cell culture models of early human brain development, raising the possibility that the disease has its origins much earlier in life, possibly during embryogenesis – the formation and development of an embryo.

22 Jun 2023

Brain organoids provide new insights into HSV-1 encephalitis

The herpes simplex virus-1 can sometimes cause a dangerous brain infection. Combining an anti-inflammatory and an antiviral could help in these cases, report scientists with the Rajewsky and Landthaler labs and the Organoid Platform at the Max Delbrück Center in Nature Microbiology.

22 Jun 2023

Blood-brain barrier model may lead to prevention of meningitis in newborns

Investigators in Israel and Italy have developed a model of the blood-brain barrier, studies of which may lead to prevention of meningitis in newborns.

22 Jun 2023

Neurons involved in creating negative emotional states and chronic stress identified

Researchers at Karolinska Institutet in Sweden have identified a group of nerve cells in the mouse brain that are involved in creating negative emotional states and chronic stress. The

22 Jun 2023

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

A study in mice reports a CRISPR/Cas9 gene-editing delivery system, capable of bypassing the blood-brain-barrier and modulating neuronal receptor pathways, to treat chronic anxiety.

20 Jun 2023

New mapping by Human Brain Project advances the understanding of neuroreceptor organization

A key challenge in neuroscience is to understand how the brain can adapt to a changing world, even with a relatively static anatomy.

19 Jun 2023

Neurodevelopmental disruptions could pave the way for Alzheimer's disease

In the cerebral cortex, neurogenesis – the formation of neural cells from stem cells – begins in the fetus from 5 weeks gestation and is almost complete by 28 weeks.

16 Jun 2023

Investigating the incidences and risks of rotavirus-associated extraintestinal complications in hospitalized children under 5

Researchers studied extraintestinal complications of rotavirus infections in children below the age of five.

16 Jun 2023

Aging impacts cellular composition across the whole fly: Study

As the body ages, organ function progressively declines and the risk for a wide range of diseases, including cardiovascular disease, cancer and neurodegenerative diseases, increases. Understanding how the body ages is an intense area of research as it will potentially illuminate ways to promote healthy aging.

16 Jun 2023

Human brain signals resemble swirling spirals: Study

University of Sydney and Fudan University scientists have discovered human brain signals traveling across the outer layer of neural tissue that naturally arrange themselves to resemble swirling spirals.

16 Jun 2023

Study offers a new perspective on the reproductive toxicity of phthalates

Prenatal exposure to chemicals called phthalates, which are used in hundreds of products, may lead to hormonal changes in females that could affect their future fertility, suggests a study in mice being presented Thursday at ENDO 2023, the Endocrine Society's annual meeting in Chicago, Ill.

15 Jun 2023

New and significant breakthrough made to detect brain tumors

Folate-based radiopharmaceuticals can be used in positron emission tomography (PET) imaging to detect folate receptors in brain tumors.

15 Jun 2023

Detailed 3D images of the synapse offer precise geometry of interactions between individual cells

Scientists have created one of the most detailed 3D images of the synapse, the important juncture where neurons communicate with each other through an exchange of chemical signals. These nanometer scale models will help scientists better understand and study neurodegenerative diseases such as Huntington's disease and schizophrenia.

15 Jun 2023