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Drugs that block KDM4C and PRMT1 genes could be effective in treating AML

Two genes have been identified that are critical to the development of the biggest leukaemia killer, acute myeloid leukaemia (AML). Researchers at King’s College London found that drugs that selectively block these genes could be highly effective in treating this type of leukaemia.

12 Jan 2016

JINARC (tolvaptan) accepted for use in Scotland for ADPKD treatment

From today, people in Scotland with the genetic kidney disease ADPKD could benefit from JINARC® (tolvaptan) following advice issued by the Scottish Medicines Consortium (SMC) for its use in adults with chronic kidney disease (CKD) stages 1-3 at the start of treatment with evidence of rapidly progressing disease.

12 Jan 2016

Study opens new door on the causes of vision issues in astronauts

Just when you think you've seen it all, our eyes look to be victims of a low-gravity environments, too. According to new research published in the January 2016 issue of The FASEB Journal, two significant genetic differences in enzymes that direct the one-carbon pathway of metabolism can affect astronaut vision.

12 Jan 2016

McMaster University researchers take a giant leap in detecting early stages of leukemia

McMaster University researchers have taken a giant leap in identifying the early stages of a deadly cancer and predicting how it will develop in individuals.

11 Jan 2016

Cedars-Sinai researcher receives $2.5 million grant to develop risk assessment tool for sudden cardiac arrest

A Cedars-Sinai Heart Institute physician researcher has received a $2.5 million grant from the National Heart, Lung, and Blood Institute to develop a risk assessment tool that could identify patients susceptible to sudden cardiac arrest, a usually fatal heart rhythm malfunction.

11 Jan 2016

Genetic factors in puberty timing: an interview with Dr John Perry

The study focused on the genetic regions that influence age at voice breaking - a distinct developmental milestone that happens to young men as their larynx (voice box) lengthens when exposed to male hormones.

11 Jan 2016

UA researchers find genetic mutations associated with respiratory disease

Asthma affects more than 278 million people worldwide and can lead to serious consequences later in life. While current approved therapies address symptoms, they do not halt disease progression.

11 Jan 2016

DNA-binding protein acts like genetic traffic signal to orchestrate early stage embryonic development

New research by UC San Francisco stem cell biologists has revealed that a DNA-binding protein called Foxd3 acts like a genetic traffic signal, holding that ball of undifferentiated cells in a state of readiness for its great transformation in the third week of development.

11 Jan 2016

U-M research could lead to new ways of fighting X-linked diseases in girls and women

Nearly every girl and woman on Earth carries two X chromosomes in nearly every one of her cells -- but one of them does (mostly) nothing. That's because it's been silenced, keeping most of its DNA locked up and unread like a book in a cage.

11 Jan 2016

Salk Institute scientists find new target for glioblastoma multiforme treatment

Glioblastoma multiforme is a particularly deadly cancer. A person diagnosed with this type of brain tumor typically survives 15 months, if given the best care. The late Senator Ted Kennedy succumbed to this disease in just over a year.

11 Jan 2016

New gene editing technique could hinder retinal degeneration in rats with inherited blindness

A new technique that has the potential to treat inherited diseases by removing genetic defects has been shown for the first time to hinder retinal degeneration in rats with a type of inherited blindness, according to a Cedars-Sinai study.

11 Jan 2016

Small differences in specific genetic variant could alter nicotine consumption

Nicotine is an addictive substance and genetic factors are known to play a role in smoking behaviors. Recently, a team of researchers at Penn State and the University of Colorado determined how small differences in a particular region of the mouse genome can alter nicotine consumption.

11 Jan 2016

SDPR gene may help to predict disease progression, serve as target for future breast cancer therapies

A gene that plays a role in the development of breast cancer to metastatic disease has been identified which may help to predict disease progression and serve as a target for the development of future breast cancer therapies.

11 Jan 2016

Research shows link between lead exposure and ADHD symptoms in children with HFE C282Y gene mutation

Exposure to small amounts of lead may contribute to ADHD symptoms in children who have a particular gene mutation, according to new research published in Psychological Science, a journal of the Association for Psychological Science.

8 Jan 2016

Oxygen sensor PHD1 identified as potential target for treatment of ischemic stroke

Scientists at VIB and KU Leuven have identified the oxygen sensor PHD1 as a potential target for the treatment of brain infarction (ischemic stroke). Despite (minor) improvements in stroke treatment, stroke remains the fourth leading cause of death and the most common reason of severe disability.

8 Jan 2016

DNA damage may lead to mutation and changes in cell

A team of researchers from Colorado State University has been studying DNA damage in living cells to learn more about how genetic abnormalities arise. It has long been known that DNA molecules in every cell get constantly damaged by things from the outside environment, like sunlight, cigarette smoke and radiation. However, more recently researchers have discovered that sources from within the cell itself can sometimes be even more damaging.

7 Jan 2016

Penn study provides new insight into cause of peripartum cardiomyopathy in pregnant women

Each year approximately 1 in 1,000 pregnant women will experience peripartum cardiomyopathy, an uncommon form of often severe heart failure that occurs in the final month of pregnancy or up to five months following delivery. But the cause of peripartum cardiomyopathy has been largely unknown - until now.

7 Jan 2016

Scientists find genetic link to unexplained heart failure affecting pregnant women

Scientists have found that women who suffer unexplained heart failure towards the end of pregnancy or shortly after giving birth share certain genetic changes.

7 Jan 2016

Leading researchers reject proposed link between adeno-associated virus 2 and hepatocellular carcinoma

The conclusion drawn from a recent study that insertion of adeno-associated virus 2 (AAV2) into human DNA causes mutations leading to the development of hepatocellular carcinoma (HCC) was resoundingly rejected by leading researchers in the fields of gene therapy and molecular genetics.

7 Jan 2016

New CRISPR technology can be used to make designer babies

How should we handle the new CRISPR technology that can both advance science and medicine, but also be used to make designer babies? Scientist and author Paul Knoepfler tackles this and other difficult questions related to this revolutionary technology in his new book, GMO Sapiens: The Life-Changing Science of Designer Babies, targeted at a broad, lay audience.

7 Jan 2016

Genetic News and Research

Drugs that block KDM4C and PRMT1 genes could be effective in treating AML

JINARC (tolvaptan) accepted for use in Scotland for ADPKD treatment

Study opens new door on the causes of vision issues in astronauts

McMaster University researchers take a giant leap in detecting early stages of leukemia

Cedars-Sinai researcher receives $2.5 million grant to develop risk assessment tool for sudden cardiac arrest

Genetic factors in puberty timing: an interview with Dr John Perry

UA researchers find genetic mutations associated with respiratory disease

DNA-binding protein acts like genetic traffic signal to orchestrate early stage embryonic development

U-M research could lead to new ways of fighting X-linked diseases in girls and women

Salk Institute scientists find new target for glioblastoma multiforme treatment

New gene editing technique could hinder retinal degeneration in rats with inherited blindness

Small differences in specific genetic variant could alter nicotine consumption

SDPR gene may help to predict disease progression, serve as target for future breast cancer therapies

Research shows link between lead exposure and ADHD symptoms in children with HFE C282Y gene mutation

Oxygen sensor PHD1 identified as potential target for treatment of ischemic stroke

DNA damage may lead to mutation and changes in cell

Penn study provides new insight into cause of peripartum cardiomyopathy in pregnant women

Scientists find genetic link to unexplained heart failure affecting pregnant women

Leading researchers reject proposed link between adeno-associated virus 2 and hepatocellular carcinoma

New CRISPR technology can be used to make designer babies

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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