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Four unrelated families share identical BAP1 mutation that causes several cancers

University of Hawai'i Cancer Center researchers discovered members of four families, apparently unrelated and living in different states across the US, shared the identical mutation of a gene called BAP1 that causes mesothelioma, melanoma, renal carcinoma and other cancers.

23 Dec 2015

Researchers find mechanism that alters expression of key genes to make windows of stress-related neuroplasticity

Chronic stress can lead to changes in neural circuitry that leave the brain trapped in states of anxiety and depression. But even under repeated stress, brief opportunities for recovery can open up, according to new research at The Rockefeller University.

23 Dec 2015

Researchers awarded $16 million NIH/NINDS grant to create methods for detecting CTE during life

Researchers from Boston University, the Cleveland Clinic, Banner Alzheimer's Institute and Brigham and Women's Hospital in Boston, have been awarded a $16 million grant from the National Institutes of Health/National Institute of Neurological Disorders and Stroke.

23 Dec 2015

Study identifies genetic factors that play role in AMD

An international study has identified the number of genetic factors known to play a role in age-related macular degeneration (AMD), the worldwide leading cause of blindness in the elderly.

23 Dec 2015

Researchers describe epigenetic mechanisms underlying the development of cerebellum

From before birth through childhood, connections form between neurons in the brain, ultimately making us who we are. So far, scientists have gained a relatively good understanding of how neural circuits become established, but they know less about the genetic control at play during this crucial developmental process.

23 Dec 2015

New study reveals why some vestibular schwannomas cause hearing loss

A new study at Massachusetts Eye and Ear showed that in some cases of vestibular schwannoma, a sometimes-lethal tumor often associated with neurofibromatosis 2 (NF2), secretions from the tumor contain toxic molecules that damage the inner ear.

23 Dec 2015

Prevalence of chronic kidney disease considerably varies across Europe

The first study to carefully characterize the prevalence of chronic kidney disease (CKD) across Europe found considerable variation. The findings appear in an upcoming issue of the Journal of the American Society of Nephrology.

22 Dec 2015

Researchers reveal inherited genetic errors across 12 cancer types

Researchers long have known that some portion of the risk of developing cancer is hereditary and that inherited genetic errors are very important in some tumors but much less so in others.

22 Dec 2015

CSL submits rIX-FP new drug application to Japan's Pharmaceuticals and Medical Devices Agency

Global biotherapeutics leader CSL Behring announced today that the company has submitted its new drug application to Japan's Pharmaceuticals and Medical Devices Agency for its investigational fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP).

22 Dec 2015

Study reveals new genetic factors linked to age-related macular degeneration

An international study of about 43,000 people has significantly expanded the number of genetic factors known to play a role in age-related macular degeneration (AMD), a leading cause of vision loss among people age 50 and older.

22 Dec 2015

Scientists identify 52 genetic variations associated with age-related macular degeneration

In one of the latest examples of precision medicine, teams of geneticists from nine countries, involving more than 100 scientists, analyzed the genes of more than 33,000 individuals in the hope of finding genetic variations responsible for age-related macular degeneration (AMD), the leading cause of vision loss among people age 50 or older.

22 Dec 2015

Drug that boosts activity in the brain's 'garbage disposal' system may slow Alzheimer's disease

A drug that boosts activity in the brain's "garbage disposal" system can decrease levels of toxic proteins associated with Alzheimer's disease and other neurodegenerative disorders and improve cognition in mice, a new study by neuroscientists at Columbia University Medical Center has found.

22 Dec 2015

Scientists identify genes linked to human intelligence

Scientists from Imperial College London have identified for the first time two clusters of genes linked to human intelligence.

22 Dec 2015

New drug approved by FDA for treatment of von Willebrand disease

"VONVENDI [von Willebrand factor (Recombinant)]", the new drug from Baxalta Incorporated, a global biopharmaceutical company recently spun off from Baxter International, has just been approved by the United States Food and Drug Administration.

22 Dec 2015

Small airway-on-a-chip enables analysis of human COPD and asthma

A research team at the Wyss Institute for Biologically Inspired Engineering at Harvard University leveraged its organ-on-a-chip technology to develop a model of the human small airway in which lung inflammatory diseases, such as chronic obstructive pulmonary disease (COPD), the third leading cause of mortality worldwide, and asthma can be studied outside the human body.

22 Dec 2015

Premature babies at higher risk of developing autism in later childhood

Extremely premature babies run a much higher risk of developing autism in later childhood, and even during the neonate period differences are seen in the brains of those who do. This according to a new study by researchers from Karolinska Institutet and Karolinska University Hospital in Sweden.

22 Dec 2015

New easy-to-use computer program can quickly identify drug-resistant infections

Scientists have developed an easy-to-use computer program that can quickly analyse bacterial DNA from a patient's infection and predict which antibiotics will work, and which will fail due to drug resistance. The software is currently being trialled in three UK hospitals to see whether it could help speed up diagnosis of drug-resistant infections and enable doctors to better target the prescription of antibiotics.

21 Dec 2015

Mirati announces initiation of glesatinib Phase 2 clinical trial in NSCLC patients

Mirati Therapeutics, Inc. today announced that the Phase 2 clinical trial of glesatinib (MGCD265) has commenced. The Company also announced that "glesatinib" is the proposed generic name for MGCD265.

21 Dec 2015

Heidelberg neurobiologists identify Dnmt3a2 protein that boosts memory performance

Increasing the level of a certain DNA-modified enzyme in the brain significantly improves cognitive ability. The discovery was made by the research team led by Prof. Dr. Hilmar Bading at the Interdisciplinary Center for Neurosciences of Heidelberg University. Mouse experiments showed that the Dnmt3a2 protein can boost memory performance in the animals.

21 Dec 2015

Protective effects of high fitness against early death reduced in obese people, study finds

A new study, published today in the International Journal of Epidemiology, has dismissed the concept of 'fat but fit'. In contrast, the results from the new study suggest that the protective effects of high fitness against early death are reduced in obese people.

20 Dec 2015

Genetic News and Research

Four unrelated families share identical BAP1 mutation that causes several cancers

Researchers find mechanism that alters expression of key genes to make windows of stress-related neuroplasticity

Researchers awarded $16 million NIH/NINDS grant to create methods for detecting CTE during life

Study identifies genetic factors that play role in AMD

Researchers describe epigenetic mechanisms underlying the development of cerebellum

New study reveals why some vestibular schwannomas cause hearing loss

Prevalence of chronic kidney disease considerably varies across Europe

Researchers reveal inherited genetic errors across 12 cancer types

CSL submits rIX-FP new drug application to Japan's Pharmaceuticals and Medical Devices Agency

Study reveals new genetic factors linked to age-related macular degeneration

Scientists identify 52 genetic variations associated with age-related macular degeneration

Drug that boosts activity in the brain's 'garbage disposal' system may slow Alzheimer's disease

Scientists identify genes linked to human intelligence

New drug approved by FDA for treatment of von Willebrand disease

Small airway-on-a-chip enables analysis of human COPD and asthma

Premature babies at higher risk of developing autism in later childhood

New easy-to-use computer program can quickly identify drug-resistant infections

Mirati announces initiation of glesatinib Phase 2 clinical trial in NSCLC patients

Heidelberg neurobiologists identify Dnmt3a2 protein that boosts memory performance

Protective effects of high fitness against early death reduced in obese people, study finds

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

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