Compound News and Research

RSS

USF researchers discover promising new compound to open constricted airways

Despite the progress made in managing asthma and chronic obstructive pulmonary disease (COPD), poorly controlled symptoms for both respiratory diseases can lead to severe shortness of breath, hospitalizations or even death.

4 Jan 2021

Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells

In 1986, cellular biochemist Kazumitsu Ueda, currently at Kyoto University's Institute for Integrated Cell-Material Sciences, discovered that a protein called ABCB1 could transport multiple chemotherapeutics out of some cancer cells, making them resistant to treatment. How it did this has remained a mystery for the past 35 years.

29 Dec 2020

Toxic pesticide turned into treatment against antibiotic-resistant bacteria

N-Aryl-C-nitroazoles are an important class of heterocyclic compounds. They are used as pesticides and fungicides. However, these substances could be toxic to humans and cause mutations.

29 Dec 2020

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Cancer cells are known for spreading genetic chaos. As cancer cells divide, DNA segments and even whole chromosomes can be duplicated, mutated, or lost altogether. This is called chromosomal instability, and scientists at Memorial Sloan Kettering have learned that it is associated with cancer's aggressiveness.

28 Dec 2020

Researchers develop new drug discovery method targeting membrane proteins on live cells

A research team led by Dr Xiaoyu LI from the Research Division for Chemistry, Faculty of Science, in collaboration with Professor Yizhou LI from School of Pharmaceutical Sciences, Chongqing University and Professor Yan CAO from School of Pharmacy, Second Military Medical University in Shanghai has developed a new drug discovery method targeting membrane proteins on live cells.

28 Dec 2020

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A new study preprint on the bioRxiv* server demonstrates the ability of a fatty acid synthase inhibitor to improve the survival of mice infected with murine hepatitis virus. In so doing, it adds to the sum of knowledge about the relationship of SARS-CoV-2 with cholesterol metabolism in the host cell.

24 Dec 2020

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers found that cetylpyridinium chloride, found in most mouthwashes, lowers infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, likely by inhibiting viral fusion with target cells. With more tests to prove validity, mouthwashes could be a simple, cheap way of curbing transmission.

24 Dec 2020

Researchers identify new weapon to battle the rising tide of antibiotic-resistant bacteria

As scientists around the globe wage war against a novel, deadly virus, one University of Colorado Boulder lab is working on new weapons to battle a different microbial threat: a rising tide of antibiotic-resistant bacteria which, if left unchecked, could kill an estimated 10 million people annually by 2050.

23 Dec 2020

Research shows how colanic acid extends lifespan in C. elegans

Baylor College of Medicine researcher Meng Wang had already shown that bacteria that make a metabolite called colanic acid (CA) could extend the lifespan of worms in her lab by as much as 50%, but her collaboration with Rice University synthetic biologist Jeffrey Tabor is providing tools to answer the bigger question of how the metabolite imparts longer life.

22 Dec 2020

New drug starves cancer cells by attacking mitochondria

A newly developed compound starves cancer cells by attacking their "power plants" - the so-called mitochondria.

22 Dec 2020

Anti-diarrhea drug triggers cell death in glioblastoma cells

In cell culture, loperamide, a drug commonly used against diarrhea, proves effective against glioblastoma cells. A research team at Goethe University has now unraveled the drug’s mechanisms of action of cell death induction and – in doing so – has shown how this compound could help attack brain tumors that otherwise are difficult to treat.

22 Dec 2020

Invirsa signs license agreement with AWRI to expand treatment platform for respiratory diseases

Invirsa, a Columbus-based pharmaceutical company, today announced execution of a license agreement with the Abigail Wexner Research Institute (AWRI) at Nationwide Children's Hospital as Invirsa seeks to broaden its treatment platform to address respiratory diseases.

20 Dec 2020

Novel SARS-CoV-2 neutralizing antibody enters Phase 1/2a clinical study

Cologne University Hospital (UKK), University of Marburg (UMR), the German Center for Infection Research (DZIF) and Boehringer Ingelheim today announced the initiation of Phase 1/2a clinical investigation of BI 767551, a new SARS-CoV-2 neutralizing antibody.

18 Dec 2020

MFCR awards new grants to support an emerging approach to cancer therapeutics

The Mark Foundation for Cancer Research has awarded five new grants in support of an important, emerging approach to cancer therapeutics.

17 Dec 2020

BU researchers awarded $2.4 million NIH grant to study idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a serious chronic disease that affects the tissue surrounding the air sacs in the lungs.

17 Dec 2020

Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

A preprint indicates that SARS-CoV-2 requires cholesterol to accomplish entry into the host cells and membrane fusion.

17 Dec 2020

Low-intensity pulsed ultrasound combined with microbubbles might enhance chemotherapy delivery

Application of low-intensity pulsed ultrasound in combination with microbubbles might enhance the delivery of chemotherapy medication used for treating cancers.

17 Dec 2020

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

As researchers strive to find safe therapeutics for COVID 19, a study suggests that preventing the movement of cholesterol may inhibit viral entry by up to 80%.

17 Dec 2020

Fluorescence guidance can enable surgeons to assess cancer tissues in real-time

A clinical research study published in the British Journal of Surgery shows that fluorescence guidance (where a fluorescent chemical compound re-emits light with a long wavelength) can enable a colorectal surgeon to assess cancer tissues visually and with more specificity in real-time during surgery, by utilising near-infrared (NIR) light from an administered fluorophore in conjunction with artificial intelligence (AI) methods.

17 Dec 2020

Researchers design new chemical tool with high configurational stability, catalytic activity

Researchers have designed and built a new chemical tool inspired by natural metal-containing enzymes in living organisms. The product, a tetrahedral "chiral zinc", maintains its shape for years, providing a new structure with exciting possibilities for manufacturing pharmaceuticals and optical electronics.

15 Dec 2020

Compound News and Research

USF researchers discover promising new compound to open constricted airways

Protein employs twist‐and‐squeeze mechanism to expel chemotherapeutics from cancer cells

Toxic pesticide turned into treatment against antibiotic-resistant bacteria

Researchers discover how chromosomal instability allows cancer cells to avoid immune defenses

Researchers develop new drug discovery method targeting membrane proteins on live cells

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers identify new weapon to battle the rising tide of antibiotic-resistant bacteria

Research shows how colanic acid extends lifespan in C. elegans

New drug starves cancer cells by attacking mitochondria

Anti-diarrhea drug triggers cell death in glioblastoma cells

Invirsa signs license agreement with AWRI to expand treatment platform for respiratory diseases

Novel SARS-CoV-2 neutralizing antibody enters Phase 1/2a clinical study

MFCR awards new grants to support an emerging approach to cancer therapeutics

BU researchers awarded $2.4 million NIH grant to study idiopathic pulmonary fibrosis

Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

Low-intensity pulsed ultrasound combined with microbubbles might enhance chemotherapy delivery

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

Fluorescence guidance can enable surgeons to assess cancer tissues in real-time

Researchers design new chemical tool with high configurational stability, catalytic activity

Advancing therapeutic biopolymer development eBook

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring

Latest News