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Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Isolated monoclonal antibodies neutralize SARS-CoV-2 Delta and Omicron variants.

28 Nov 2022

Study reveals a promising therapeutic target for Alzheimer's disease

In a recent search for gene variants associated with Alzheimer's disease (AD), several affected families showed a mutation in an enzyme called protein kinase C-alpha (PKCα). Family members with this mutation had AD; those without the mutation did not.

28 Nov 2022

Scientists unravel how bats harbor many viruses without developing symptoms

Bats are asymptomatic carriers of a multitude of viruses that are pathogenic to most other mammals. How has their immune system evolved to shield them from these pathogens?

28 Nov 2022

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

In a new study, researchers developed two monkeypox (MPX) virus (MPXV) quadrivalent messenger ribonucleic acid (mRNA) vaccines, mRNA-A-lipid nanoparticle (LNP) and mRNA-B-LNP.

28 Nov 2022

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies.

28 Nov 2022

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

In a recent study, researchers confirmed that feline coronavirus infection induced the production of cross-reactive antibodies against the SARS-CoV-2 receptor-binding domain in domestic cats.

28 Nov 2022

Glycan signatures in rheumatic diseases and their associated functional implications

A new paper examines the understanding of glycosylation in an array of rheumatic diseases and indicates the potential for therapeutic interventions using the same mechanism.

28 Nov 2022

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

In a recent study published in The Journal of Immunology, a team of researchers from Japan examined the memory B and T cell responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein after the booster dose of the coronavirus disease 2019 (COVID-19) messenger ribonucleic acid (mRNA) vaccine BNT162b2.

27 Nov 2022

Scientists investigate the evolutionary origin of SARS-CoV-2 using recombination-aware phylogenetic analysis

A study has employed Bacter to identify recombination events with the RBD regions of the Sarbecovirus genome.

25 Nov 2022

The potential of Sofosbuvir against COVID-19 neurological symptoms

Researchers discuss how SARS-CoV-2 infects cortical neurons and damages their synapses that form the connection between brain cells.

25 Nov 2022

New CRISPR-based tool can snip out faulty genes and replace them with new ones

Building on the CRISPR gene-editing system, MIT researchers have designed a new tool that can snip out faulty genes and replace them with new ones, in a safer and more efficient way.

24 Nov 2022

Study finds that pediatric stroke is associated with COVID-19 infections but not with multisystem inflammatory syndrome

Researchers investigated whether coronavirus disease 2019 (COVID-19) and multisystem inflammatory syndrome in children (MIS-C) were associated with an increased risk of ischemic stroke in pediatric populations.

24 Nov 2022

Study: Nearly 1 in 7 Americans regularly experience bloating issues

Nearly 1 in 7 Americans experience bloating on a weekly basis, and most aren't seeking professional care for it, according to a new study led by Cedars-Sinai investigators.

24 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Researchers make an incredible discovery about mammalian brains

In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery.

23 Nov 2022

The safety and immunogenicity of a fourth dose of NVX-CoV2373

Researchers assessed the immunogenicity and safety of a fourth homologous boost dose of a recombinant SARS-CoV-2 spike protein vaccine called NVX-CoV2373.

23 Nov 2022

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

Researchers evaluated the serological responses elicited by COVID-19 vaccinations in children who developed MIS-C following a previous SARS-CoV-2 infection.

23 Nov 2022

New York sewer rats are easily infected by SARS-CoV-2, according to new study

Researchers evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure among rats inhabiting New York City (NYC) during the fall of 2021.

23 Nov 2022

Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

A novel mAb against the SARS-CoV-2 RBD through a hybridoma technique, followed by chimerization and expression in plants.

22 Nov 2022

SARS-CoV-2 seroprevalence in domestic cats has increased over time

Researchers evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission among domestic cats in the United Kingdom (UK).

22 Nov 2022

Enzyme News and Research

Isolated monoclonal antibodies targeting SARS-CoV-2 S1/S2 cleavage effective against Delta and Omicron

Study reveals a promising therapeutic target for Alzheimer's disease

Scientists unravel how bats harbor many viruses without developing symptoms

Study on the immunogenicity of monkeypox virus messenger ribonucleic acid-based vaccine candidates

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

Feline coronavirus-infected domesticated cats found to possess cross-reactive anti-SARS-CoV-2 antibodies

Glycan signatures in rheumatic diseases and their associated functional implications

Memory B and T cells responses differ when induced by SARS-CoV-2 infections or booster vaccinations

Scientists investigate the evolutionary origin of SARS-CoV-2 using recombination-aware phylogenetic analysis

The potential of Sofosbuvir against COVID-19 neurological symptoms

New CRISPR-based tool can snip out faulty genes and replace them with new ones

Study finds that pediatric stroke is associated with COVID-19 infections but not with multisystem inflammatory syndrome

Study: Nearly 1 in 7 Americans regularly experience bloating issues

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Researchers make an incredible discovery about mammalian brains

The safety and immunogenicity of a fourth dose of NVX-CoV2373

The binding and functional serologic responses to COVID-19 vaccination in children with history of MIS-C

New York sewer rats are easily infected by SARS-CoV-2, according to new study

Plant-based monoclonal antibody increases potency of antibody cocktail against SARS-CoV-2 Omicron variant

SARS-CoV-2 seroprevalence in domestic cats has increased over time

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