Metastasis News and Research

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Metastasis is the spread of cancer from one part of the body to another. A tumor formed by cells that have spread is called a “metastatic tumor” or a “metastasis.” The metastatic tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases

Scientists potentially discover new therapeutic targets to halt progression of tumor cells

Chronic inflammation is directly associated with several types of cancer, yet the reasons as to why this happens at a cellular level remain unclear. Now, an international team of scientists led by researchers at The Wistar Institute has identified a multistep process showing not only how these cancers develop but also potentially discovering new therapeutic targets that could halt the formation and progression of tumor cells.

10 Feb 2015

Study reveals how low levels of profilin 1 protein in breast tumours invade other tissues

A new study led by José Javier Bravo-Cordero, Spanish researcher at the Albert Einstein College of Medicine in New York, details how cells with low levels of the profilin 1 protein in breast tumours increase their capacity to metastasise and invade other tissues.

9 Feb 2015

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

At the "Symposium on the Application of Genetic Testing in Individualized Diagnosis and Treatment of Tumor" recently held in Tianjin, the research team led by Professor Hao Jihui of the Pancreas Oncology Department of Tianjin Medical University Cancer Hospital announced that they had achieved a major breakthrough in the field of nano-carrier drugs for pancreatic cancer.

6 Feb 2015

New study provides better understanding of how stem cells give rise to tumors

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered a precise stem cell signaling process that can lead to intestinal tumors if disrupted. The findings add to our understanding of how stem cells give rise to tumors and identify specific stem cell molecules that may be targeted to prevent the onset, progression, and recurrence of intestinal cancers.

6 Feb 2015

Prostate cancer patients with detectable post-operative PSA should receive more aggressive treatment

Prostate cancer patients with detectable prostate specific antigen (PSA) following radical prostatectomy should receive earlier, more aggressive radiation therapy treatment, according to a study published in the February 1, 2015 issue of the International Journal of Radiation Oncology * Biology * Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology.

6 Feb 2015

Scientists investigate how T cells in colorectal tumors actively fight cancer

In recent years, a standard follow-up to colorectal cancer surgery has been to analyze the tumor tissue for the presence of immune cells. Finding high quantities of cytotoxic T cells, or "killer cells", means that there is a good chance that the disease will take a favorable course and that the risk of metastasis is comparatively low.

5 Feb 2015

Researchers suggest novel concept for developing vaccines against HIV and cancer

A experimental trial has shown successful by inducing serum in mice and has been highly neutralizing towards those ailments.

4 Feb 2015

Clusters of gene-blocking microRNAs can limit spread of cancer

Cancers that have spread throughout the body, a process known as metastasis, are difficult, often impossible, to control. They are the leading cause of cancer-related deaths.

4 Feb 2015

Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

A new study developed at the Center for Gastrointestinal Cancer Research and the Center for Epigenetics, Cancer Prevention and Cancer Genomics at Baylor Research Institute has discovered unique metastasis-specific microRNA signatures in primary colorectal cancers that could predict prognosis and distant metastasis in colorectal cancer.

31 Jan 2015

NR2F1 gene: A 'master regulator' of tumor cell growth

Two existing cancer drugs turn on a gene that tells tumor cells to remain inactive, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published today in Nature Communications.

31 Jan 2015

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Researchers Irving L. Weissman and Joan Massagué have won this year's Charles Rodolphe Brupbacher Prize for Cancer Research: Weissman, from Stanford University, for his work on healthy and sick stem cells; Massagué, from Memorial Sloan Kettering Cancer Center in New York, for his research on metastatic spread.

31 Jan 2015

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), led by Oscar Martínez Tirado participated in an international study which suggests inhibition of Sirtuin1 (SIRT1) protein as a future treatment option for metastatic Ewing sarcoma. The results of the study were published in the journal Cancer Research.

31 Jan 2015

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

The Damon Runyon Cancer Research Foundation, a non-profit organization focused on supporting innovative early career researchers, named 15 new Damon Runyon Fellows at its fall Fellowship Award Committee review. The recipients of this prestigious, four-year award are outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators across the country.

31 Jan 2015

Researchers one step closer to identifying how lung cancer cells metastasize

Smoking is the leading cause of lung cancer, and it is estimated that more than 159,000 people in the United States died from the disease last year. Most of these deaths were because the cancer had spread to other organ sites. Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.

28 Jan 2015

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

Patients with anaplastic lymphoma kinase-rearranged non-small-cell lung cancer who have leptomeningeal metastases may benefit from treatment with the second-generation ALK inhibitor alectinib, a case series suggests.

28 Jan 2015

SRS fails to improve survival for NSCLC brain metastases patients

Phase III trial findings suggest that carrying out stereotactic radiosurgery before chemotherapy does not improve overall survival for non-small-cell lung cancer patients with asymptomatic brain metastases compared with chemotherapy alone.

28 Jan 2015

HCI researchers find cell mechanism that may trigger pancreatic cancer

Researchers at Huntsman Cancer Institute at the University of Utah have found that defects in how cells are squeezed out of overcrowded tissue to die, a process called extrusion, may be a mechanism by which pancreatic cancer begins. From these findings, they may have identified an effective way to reverse the defective extrusion's effects without destroying normal tissues nearby.

28 Jan 2015

Lund researchers find new way to identify malignant tumours in children

A research group at Lund University in Sweden has found a new way to identify the most malignant tumours in children. The method involves studying genetic 'micro-variation', rather than the presence of individual mutations.

28 Jan 2015

Researchers decode how cancer uses cell-cell interaction mechanism to promote metastasis

Cancer uses a little-understood element of cell signaling to hijack the communication process and spread, according to Rice University researchers.

27 Jan 2015

NMR in cancer research: an interview with Andy Byrd

My research these days is generally classified as structural biology, although as I trained in chemistry. I specialize in nuclear magnetic resonance (NMR) applied to biological problems. Our lab is very interested in studying mammalian proteins, particularly systems involved in cancer, in order to try to understand mechanisms to provide that information for our collaborators, and for the general knowledge of the community as well.

From Bruker BioSpin Group 26 Jan 2015

Metastasis News and Research

Further Reading

Scientists potentially discover new therapeutic targets to halt progression of tumor cells

Study reveals how low levels of profilin 1 protein in breast tumours invade other tissues

Chinese researchers achieve major breakthrough in nano-carrier drugs for pancreatic cancer

New study provides better understanding of how stem cells give rise to tumors

Prostate cancer patients with detectable post-operative PSA should receive more aggressive treatment

Scientists investigate how T cells in colorectal tumors actively fight cancer

Researchers suggest novel concept for developing vaccines against HIV and cancer

Clusters of gene-blocking microRNAs can limit spread of cancer

Study discovers microRNA signatures that could predict prognosis, distant metastasis in colorectal cancer

NR2F1 gene: A 'master regulator' of tumor cell growth

Two researchers receive Charles Rodolphe Brupbacher Prize for Cancer Research

Inhibition of SIRT1 protein may hold promise for treatment of metastatic Ewing sarcoma

Damon Runyon Cancer Research Foundation names 15 new Damon Runyon Fellows

Researchers one step closer to identifying how lung cancer cells metastasize

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

SRS fails to improve survival for NSCLC brain metastases patients

HCI researchers find cell mechanism that may trigger pancreatic cancer

Lund researchers find new way to identify malignant tumours in children

Researchers decode how cancer uses cell-cell interaction mechanism to promote metastasis

NMR in cancer research: an interview with Andy Byrd

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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