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Gestational diabetes mellitus screening provides more health benefits to pregnant women

A local research study conducted by KK Women's and Children's Hospital and Duke-NUS Graduate Medical School has found that pregnant patients benefit most from gestational diabetes mellitus (GDM) screening as it allows for timely interventions and brings about health benefits that far outweigh the cost.

18 Nov 2015

Researchers identify genetic mutation associated with reckless drunken behavior

University of Helsinki researchers have identified a genetic mutation which renders carriers susceptible to particularly impulsive and reckless behaviour when drunk. More than one hundred thousand Finns carry this mutation.

17 Nov 2015

HITLAB selects five finalists for HITLAB World Cup

HITLAB has selected five finalists for its HITLAB World Cup, an international competition that promotes original solutions to pressing healthcare challenges. The best and brightest in healthcare innovation, the finalists, will present their ideas at the HITLAB Innovators SummitSM on December 4, 2015, at Columbia University's Alfred Lerner Hall.

17 Nov 2015

AstraZeneca announces FDA approval of TAGRISSO (AZD9291) for treatment of lung cancer patients

AstraZeneca today announced that the US Food and Drug Administration has approved TAGRISSO (AZD9291) 80mg once-daily tablets for the treatment of patients with metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive non-small cell lung cancer (NSCLC), as detected by an FDA-approved test, who have progressed on or after EGFR tyrosine kinase inhibitor (TKI) therapy.

17 Nov 2015

Study reveals why colorectal cancer still returns in some patients after treatment

Cetuximab, marketed as Erbitux, is one of the key therapies for metastatic colorectal cancer. Yet the cancer still returns in some patients, shortening overall survival.

17 Nov 2015

Research shows how scientists altered stem cells, triggered bone growth

Imagine you have a bone fracture or a hip replacement, and you need bone to form, but you heal slowly - a common fact of life for older people. Instead of forming bone, you could form fat. Researchers at the University of North Carolina School of Medicine may have found a way to tip the scale in favor of bone formation. They used cytochalasin D, a naturally occurring substance found in mold, as a proxy to alter gene expression in the nuclei of mesenchymal stem cells to force them to become osteoblasts (bone cells).

17 Nov 2015

Bullies and victims at risk for eating disorders

Being bullied in childhood has been associated with increased risk for anxiety, depression and even eating disorders. But according to new research, it's not only the victims who could be at risk psychologically, but also the bullies themselves.

17 Nov 2015

Researchers identify molecular patterns that dominate gene expression in the human brain

The human brain may be the most complex piece of organized matter in the known universe, but Allen Institute researchers have begun to unravel the genetic code underlying its function. Research published this month in Nature Neuroscience identified a surprisingly small set of molecular patterns that dominate gene expression in the human brain and appear to be common to all individuals, providing key insights into the core of the genetic code that makes our brains distinctly human.

17 Nov 2015

Drug prevents onset of cognitive and cellular effects in mouse model of Alzheimer’s disease

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long-term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

17 Nov 2015

Improved gene therapy treatment shows promise in mice with cystic fibrosis

An improved gene therapy treatment can cure mice with cystic fibrosis (CF). Cell cultures from CF patients, too, respond well to the treatment. Those are the encouraging results of a study presented by the Laboratory for Molecular Virology and Gene Therapy at KU Leuven, Belgium.

17 Nov 2015

Helmholtz Centre for Infection Research scientists identify promising antitumor agent

Support comes out of the ground: Scientists from the Helmholtz Centre for Infection Research in Germany have identified a terrestrial myxobacterium as a promising source for the bengamide class of natural products, which were originally thought to be secondary metabolites of marine sponges only.

17 Nov 2015

MedUni Vienna researchers discover genetic cause of a rare disease

Researchers at MedUni Vienna have discovered the genetic cause of a rare disease characterized by life-threatening "liver crises" in early childhood and subsequent manifestation of neurological symptoms, such as neuropathy and ataxia (a movement disorder), when they reach school age.

15 Nov 2015

New tool may help diagnose and treat Parkinson's disease in early stages

A group of experts working under the umbrella of the International Parkinson and Movement Disorder Society, have developed a new tool for healthcare professionals that they hope will mark a significant advancement in the diagnosis and treatment of Parkinson's disease, especially in its early stages.

15 Nov 2015

Diabetes prevention begins in the womb

60 million people worldwide are living with diabetes mellitus, and one in ten people over the age of 25 will develop the condition (type 2) at some stage in their lives. Globally, around 3.4 million people die from diabetes and its consequences every year. "Every six seconds, somebody somewhere in the world dies from diabetes", says Alexandra Kautzky-Willer from the Department of Endocrinology and Metabolism at the MedUni Vienna's University Department of Internal Medicine III.

13 Nov 2015

Houston Methodist investigator awarded NCI grant to study detection strategies for breast cancer-specific subtypes

The National Cancer Institute awarded Houston Methodist investigator Randa El-Zein, M.B., Ch.B., Ph.D., a $2.8 million, five-year U01 grant to combine mammography features with blood-based biomarkers to more precisely predict a woman's risk for breast cancer-specific subtypes.

13 Nov 2015

Research identifies liver pathway that contributes to negative effects of high-fat, high-cholesterol junk food diet

It's no secret that a high-fat, high-cholesterol "junk food" diet has been linked to major health problems, including high blood cholesterol and the buildup of plaques in the arteries, known as atherosclerosis.

13 Nov 2015

TGen: PPF drug could help treat patients with deadly brain cancer

In a significant breakthrough, the Translational Genomics Research Institute has identified a drug, propentofylline or PPF, that could help treat patients with deadly brain cancer.

13 Nov 2015

Intake of gluten increases risk of celiac disease in children

Intake of gluten up until two years of age increases risk of celiac disease at least two-fold in children with genetic risk factors for this disease, according a study published in Clinical Gastroenterology and Hepatology the official clinical practice journal of the American Gastroenterological Association.

13 Nov 2015

Natera's total revenues decrease 2.9% to $44.9 million in third quarter 2015

Natera, Inc., a leader in non-invasive genetic testing and the analysis of circulating cell-free DNA, today reported financial results for the third quarter ended September 30, 2015 and provided an update on recent business progress.

From Natera 13 Nov 2015

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

Mayo Clinic's Florida campus was awarded a $5.3 million grant from the National Institutes of Health to identify vascular risk factors in aging and dementia, and translate that knowledge into studying potential targets for treatment.

12 Nov 2015

Genetic News and Research

Gestational diabetes mellitus screening provides more health benefits to pregnant women

Researchers identify genetic mutation associated with reckless drunken behavior

HITLAB selects five finalists for HITLAB World Cup

AstraZeneca announces FDA approval of TAGRISSO (AZD9291) for treatment of lung cancer patients

Study reveals why colorectal cancer still returns in some patients after treatment

Research shows how scientists altered stem cells, triggered bone growth

Bullies and victims at risk for eating disorders

Researchers identify molecular patterns that dominate gene expression in the human brain

Drug prevents onset of cognitive and cellular effects in mouse model of Alzheimer’s disease

Improved gene therapy treatment shows promise in mice with cystic fibrosis

Helmholtz Centre for Infection Research scientists identify promising antitumor agent

MedUni Vienna researchers discover genetic cause of a rare disease

New tool may help diagnose and treat Parkinson's disease in early stages

Diabetes prevention begins in the womb

Houston Methodist investigator awarded NCI grant to study detection strategies for breast cancer-specific subtypes

Research identifies liver pathway that contributes to negative effects of high-fat, high-cholesterol junk food diet

TGen: PPF drug could help treat patients with deadly brain cancer

Intake of gluten increases risk of celiac disease in children

Natera's total revenues decrease 2.9% to $44.9 million in third quarter 2015

Mayo Clinic's Florida campus awarded NIH grant to identify vascular risk factors in aging and dementia

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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