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Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

Researchers shine light on ‘molecular butcher’ using neutron beams

Tucked away inside cell membranes, a molecular butcher does the bidding of healthy cells but also of disease agents. It has been operating out of clear view, but researchers just shined a mighty spotlight on it.

2 Feb 2018

Researchers discover gene network that regulates the motor neuron development in growing embryo

UCLA researchers have discovered the inner workings of a gene network that regulates the development of spinal motor neurons in the growing chicken and mouse embryo.

2 Feb 2018

Higher susceptibility of some babies to Zika virus has a genetic origin, study shows

Microcephaly, brain calcification, skeletal alterations, auditory and visual deficits - these are examples of the damage that can be caused by Zika virus in babies born to mothers infected during pregnancy.

2 Feb 2018

Researchers identify cause of severe genetic disease

Mutations in the p63 protein lead to a number of disorders, but none is as severe as the AEC syndrome. Scientists at Goethe University Frankfurt in collaboration with a research group from the University of Naples Federico II have now discovered that this syndrome resembles diseases such as Alzheimer's, Parkinson's or ALS more closely than it does other p63-based syndromes.

2 Feb 2018

$Researchers develop novel method to aid fracture recovery$

Researchers develop novel method to aid fracture recovery

Researchers from Michigan Medicine have developed a novel method to aid the repair of difficult-to-heal fractures.

2 Feb 2018

New ChIPseq kit is optimized for fresh and frozen tissue samples

The new, high-performance Chromatrap ChIP-Seq kit (v.1.5) is optimized to work from fresh and frozen extracted tissue, as well as cell lines.

From Chromatrap® - Porvair Sciences Ltd 2 Feb 2018

Study unravels developmental splicing program that promotes neuronal maturation

Neurons, or nerve cells, in the brain communicate with each other by transmitting electric signals, or firing action potentials, through long processes named axons (which send out signals) and dendrites (which receive signals).

1 Feb 2018

Findings provide better understanding of cell membrane components

Research conducted by Toyohashi University of Technology in collaboration with Tohoku University elucidated the fusion process of proteoliposomes with an artificial lipid bilayer and the mechanism behind this process.

1 Feb 2018

Two bacterial species collaborate to drive development of colon cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

1 Feb 2018

Harvard scientists identify molecular machinery responsible for dopamine release in the brain

Studied for decades for its critical role in movement control and reward-seeking behaviors, the neurotransmitter dopamine has been the focus of numerous efforts to understand its activity, particularly when it goes awry in disorders such as Parkinson's and addiction.

1 Feb 2018

Free magnesium ions regulate chromosome shape, new tool shows

Japanese researchers report a new ion detector, MARIO. Using it, they show that changes in the intracellular concentration of free magnesium ions (Mg2+) is critical for the chromosome folding that must occur for cells to divide.

1 Feb 2018

Platelets play more important role in the immune system than previously thought

Platelets play a much more important role in our immune system than previously thought, according to a study published by researchers from Université Laval and Centre hospitalier universitaire de Québec Research Center.

1 Feb 2018

Scientists identify new approach to enhance bone healing

When a patient breaks a bone, there's a possibility the fracture won't heal properly or quickly -- even with the aid of pins, plates or a cast.

1 Feb 2018

Scientists discover the genetic cause of immune disorders

Scientists from the Cincinnati Children’s have successfully identified a gene mutation that affects T cell function and promotes immune disorders.

1 Feb 2018

Super-resolution microscopy provides insights into cells' amazing flexibility

One of today's sharpest imaging tools, super-resolution microscopy, produces sparkling images of what until now has been the blurry interior of cells, detailing not only the cell's internal organs and skeleton, but also providing insights into cells' amazing flexibility.

31 Jan 2018